INT63593

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Context Info
Confidence 0.14
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.45
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a2) enzyme binding (Ugt1a2)
Anatomy Link Frequency
Hyp3 1
platelet 1
Ugt1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 161 100.00 Very High Very High Very High
b2 receptor 40 100.00 Very High Very High Very High
qutenza 12 99.38 Very High Very High Very High
dorsal root ganglion 428 94.08 High High
Action potential 1 89.76 High High
vagus nerve 1 87.04 High High
Hyperalgesia 21 79.92 Quite High
Pain 48 78.64 Quite High
Inflammation 133 75.00 Quite High
Antinociceptive 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 428 94.08 High High
Pressure And Volume Under Development 1 81.52 Quite High
Hyperalgesia 25 79.92 Quite High
Pain 41 78.64 Quite High
INFLAMMATION 133 75.00 Quite High
Arthritis 120 69.20 Quite High
Arthralgia 12 5.00 Very Low Very Low Very Low
Inflammatory Pain 12 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Immunization 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In experiments with BK-gold labelling, neurones were considered positive if their relative grey value was above that of neurones from the displacement control incubations with a BK analogue that specifically binds to the B2 receptor.
B2 Binding (binds) of associated with b2 receptor and bradykinin
1) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.06 Pain Relevance 0.31
mol/ml D-Arg [Hyp3-Thi5,8-D-Phe7]-BK (Sigma), a BK analogue that specifically binds to the B2 receptor.
B2 Binding (binds) of in Hyp3 associated with b2 receptor and bradykinin
2) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0 Pain Relevance 0.32
Because a BK analogue that specifically binds to the B2 receptor completely displaced the BK-gold particle (see Materials and methods), we conclude that BK-gold binds only to B2 receptors in this experimental approach.
B2 Binding (binds) of associated with b2 receptor and bradykinin
3) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.93 Pain Relevance 0.75
This value was 0.16; thus, all neurones with grey density >0.16 were considered as positive for the antibodies or B2 receptor BK-gold binding.
B2 Binding (binding) of associated with b2 receptor and bradykinin
4) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.14 Pain Relevance 0.35
In human platelet microsomes, prostaglandin E2 formation in arachidonic acid metabolite was not inhibited by SNA but was inhibited by capsaicin and indomethacin; thromboxane B2 formation and its synthetase activity were inhibited by SNA and capsaicin. 3.
B2 Binding (formation) of in platelet associated with qutenza
5) Confidence 0.04 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8742512 Disease Relevance 0.32 Pain Relevance 0.81

General Comments

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