INT636

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Context Info
Confidence 0.48
First Reported 1976
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 54
Total Number 57
Disease Relevance 40.36
Pain Relevance 18.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (MRAP) plasma membrane (MRAP) cytoplasm (MRAP)
Anatomy Link Frequency
leukocyte 7
Reiter 3
joint 3
T-cell 2
cleft 1
MRAP (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 199 100.00 Very High Very High Very High
Arthritis 325 99.98 Very High Very High Very High
spondylitis 4 99.66 Very High Very High Very High
backache 4 99.54 Very High Very High Very High
psoriasis 138 99.32 Very High Very High Very High
rheumatoid arthritis 50 97.36 Very High Very High Very High
Inflammation 67 97.32 Very High Very High Very High
diclofenac 8 95.60 Very High Very High Very High
Pain 3 95.56 Very High Very High Very High
imagery 4 92.08 High High
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 308 100.00 Very High Very High Very High
Low Back Pain 167 100.00 Very High Very High Very High
Disease 110 100.00 Very High Very High Very High
Infection 9 100.00 Very High Very High Very High
Arthritis 83 99.98 Very High Very High Very High
Bacterial Infection 4 99.96 Very High Very High Very High
Chlamydia Infection 3 99.80 Very High Very High Very High
Spinal Diseases 1 99.76 Very High Very High Very High
Rheumatoid Arthritis 51 99.72 Very High Very High Very High
Enteritis 1 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This simultaneous occurrence of three B27 positive rheumatic diseases suggests that a patient with one "B27 positive rheumatic disease" is more susceptible to other diseases or symptoms known to be associated with the B27 antigen.
B27 Binding (associated) of associated with disease and rheumatic diseases
1) Confidence 0.48 Published 1977 Journal J Rheumatol Suppl Section Abstract Doc Link 266605 Disease Relevance 2.01 Pain Relevance 0.35
Ankylosing spondylitis and reactive arthritis triggered by either enteritis or urethritis are both associated with human leucocyte antigen (HLA) B27.
B27 Binding (associated) of in leucocyte associated with seronegative spondarthritis, spinal inflammation, enteritis, chlamydia infection and arthritis
2) Confidence 0.47 Published 1984 Journal Med. Biol. Section Abstract Doc Link 6088912 Disease Relevance 0.86 Pain Relevance 0.30
These disorders are characterised by onset usually before the age of 40 years, absence of serum autoantibodies and sometimes the association with antigen human leukocyte antigen B27.
B27 Binding (association) of in leukocyte
3) Confidence 0.47 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 18500440 Disease Relevance 1.38 Pain Relevance 0.59
Despite strong linkage of ankylosing spondylitis (AS) with human leukocyte antigen (HLA) B27, its contribution to disease susceptibility is only 15%, and additional genetic factors are likely to be involved in AS.
B27 Binding (linkage) of in leukocyte associated with disease susceptibility and spinal inflammation
4) Confidence 0.47 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 17899305 Disease Relevance 0.88 Pain Relevance 0.68
Within this family sacroiliitis and/or AS rather seemed associated with the B27 antigen itself than with the same haplotype.
B27 Spec (seemed) Binding (associated) of associated with spinal inflammation and sacroiliitis
5) Confidence 0.47 Published 1985 Journal J. Rheumatol. Section Abstract Doc Link 3876435 Disease Relevance 1.32 Pain Relevance 0.83
For the chronic cases and cases evolving into ankylosing spondylitis, the interaction between bacteria and human leukocyte antigen B27 plays an additional crucial role.
B27 Binding (interaction) of in leukocyte associated with spinal inflammation
6) Confidence 0.47 Published 2004 Journal Curr Rheumatol Rep Section Abstract Doc Link 15016341 Disease Relevance 0.91 Pain Relevance 0.48
Ankylosing spondylitis, acute anterior uveitis and reactive arthritides, including enteroarthritis and uroarthritis , are all associated with the human leucocyte antigen (HLA) B27.
B27 Binding (associated) of in leucocyte associated with spinal inflammation, reiter's syndrome and uveitis
7) Confidence 0.47 Published 1984 Journal Ann. Clin. Res. Section Abstract Doc Link 6378047 Disease Relevance 0.95 Pain Relevance 0.29
Of these disease associations, the strongest and best studied are the seronegative spondyloarthropathies which are highly associated with the B27 antigen.
B27 Binding (associated) of associated with disease
8) Confidence 0.47 Published 1977 Journal Med. Clin. North Am. Section Abstract Doc Link 300826 Disease Relevance 1.01 Pain Relevance 0.27
Spondyloarthritis tends to cluster in families and, to a great extent, is associated with human leukocyte antigen (HLA) B27.
B27 Binding (associated) of in leukocyte
9) Confidence 0.47 Published 2004 Journal Curr Rheumatol Rep Section Abstract Doc Link 15016342 Disease Relevance 0.17 Pain Relevance 0.11
Both clinical and histopathologic changes in the heart in Reiter's syndrome are analogous to those in ankylosing spondylitis, also associated with B27 antigen.
B27 Binding (associated) of in Reiter associated with spinal inflammation and syndrome
10) Confidence 0.47 Published 1982 Journal Am. J. Med. Section Abstract Doc Link 7124760 Disease Relevance 1.39 Pain Relevance 0.10
Ankylosing spondylitis and Reiter's syndrome are the two major spondyloarthropathies highly associated with human leukocyte antigen (HLA) B27.
B27 Binding (associated) of in Reiter associated with spinal inflammation and syndrome
11) Confidence 0.47 Published 1988 Journal Am. J. Med. Section Abstract Doc Link 2462350 Disease Relevance 0.30 Pain Relevance 0.15
Behcet's disease, although bearing some clinical resemblances to diseases related to the B27 antigen, i.e. ankylosing spondylitis and Reiter's syndrome, differs from them through the absence of spondylitis and because the association with B27, if it exists, is far weaker than that in ankylosing spondylitis or Reiter's disease.
B27 Binding (association) of in Reiter associated with spinal inflammation, spondylitis, syndrome and disease
12) Confidence 0.41 Published 1976 Journal J. Rheumatol. Section Abstract Doc Link 1271386 Disease Relevance 1.10 Pain Relevance 0.34
A family history is found in a third of the cases and there is a close linkage to HLA B27 (85% of cases).
B27 Binding (linkage) of associated with seronegative spondarthritis
13) Confidence 0.41 Published 1994 Journal Rev Prat Section Abstract Doc Link 7855523 Disease Relevance 0.78 Pain Relevance 0.20
An important finding was that six of the 23 patients with mechanical or non-specific low back pain had values above 1.5, unassociated with B27.
B27 Binding (unassociated) of associated with low back pain and backache
14) Confidence 0.37 Published 1979 Journal Rheumatol Rehabil Section Abstract Doc Link 158822 Disease Relevance 0.74 Pain Relevance 0.52
The association with B27 is particularly strong in PsA patients with sacroiliitis, but it has also been detected in patients with distal interphalangeal joint involvement, suggesting that the HLA-B27 association may not simply reflect the co-incidence of ankylosing spondylitis with psoriasis [31].
B27 Binding (association) of in joint associated with psoriasis, spinal inflammation, sacroiliitis and arthritis
15) Confidence 0.36 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.65 Pain Relevance 0.82
Arthritis associated with Strongyloides stercoralis infection in HLA B-27-positive African.
B-27 Binding (associated) of associated with infection and arthritis
16) Confidence 0.36 Published 2006 Journal Parasitol. Res. Section Title Doc Link 16738888 Disease Relevance 1.03 Pain Relevance 0.33
BACKGROUND: Flow cytometry-based methods are widely used to detect the ankylosing spondylitis-associated HLA-B27/B2708 antigens.
B27 Binding (associated) of associated with spinal inflammation
17) Confidence 0.36 Published 2010 Journal Cytometry B Clin Cytom Section Abstract Doc Link 19693889 Disease Relevance 0.10 Pain Relevance 0.10
The diminished mixed lymphocyte response therefore appears to be more directly associated with the disease than with the B27 antigen, and possibly represents a specific T-cell defect associated with the pathogenesis of the disease.
B27 Binding (associated) of in T-cell associated with disease
18) Confidence 0.36 Published 1978 Journal Tissue Antigens Section Abstract Doc Link 151353 Disease Relevance 0.53 Pain Relevance 0.33
Two B27 alleles have been reported to lack association with AS: B*2706 among Southeast Asian populations, and B*2709 among Sardinians.
B27 Neg (lack) Binding (association) of associated with spinal inflammation
19) Confidence 0.36 Published 2002 Journal Best Pract Res Clin Rheumatol Section Abstract Doc Link 12406434 Disease Relevance 0.89 Pain Relevance 0.38
The association of HLA B27 with AS was confirmed, but no strong evidence for the same or other HLA markers being associated with SI was found.
B27 Binding (association) of associated with seronegative spondarthritis, spinal inflammation and sacroiliitis
20) Confidence 0.36 Published 1977 Journal J Rheumatol Suppl Section Abstract Doc Link 266597 Disease Relevance 0.96 Pain Relevance 0.44

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