INT63607

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.48
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
granulocytes 1
myeloid cells 1
lungs 1
amniotic fluid 1
neutrophil 1
Pbrgcsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 124 100.00 Very High Very High Very High
Pain 7 99.82 Very High Very High Very High
dexamethasone 8 99.80 Very High Very High Very High
Inflammation 57 95.68 Very High Very High Very High
chemokine 60 93.92 High High
IPN 1 93.56 High High
ischemia 69 93.44 High High
peripheral neuropathy 5 91.64 High High
headache 1 86.48 High High
positron emission tomography 3 81.92 Quite High
Disease Link Frequency Relevance Heat
Infection 58 99.60 Very High Very High Very High
Hypoxia 36 99.58 Very High Very High Very High
Apoptosis 30 99.34 Very High Very High Very High
Neutropenia 11 99.16 Very High Very High Very High
Pain 6 98.40 Very High Very High Very High
Cancer 12 98.24 Very High Very High Very High
Fever 1 97.76 Very High Very High Very High
Vomiting 3 97.68 Very High Very High Very High
Fatigue 7 96.80 Very High Very High Very High
INFLAMMATION 64 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucose (136 +/- 45 mg/dl) and lactate dehydrogenase (195 +/- 38) increased significantly after stimulation with G-CSF plus dexamethasone but returned to baseline levels at the follow-up visit.
Positive_regulation (stimulation) of G-CSF associated with dexamethasone
1) Confidence 0.42 Published 2004 Journal J Clin Apher Section Abstract Doc Link 15493056 Disease Relevance 0.33 Pain Relevance 0.43
Combined administration of G-CSF and dexamethasone for the mobilization of granulocytes in normal donors: optimization of dosing.
Positive_regulation (administration) of G-CSF in granulocytes associated with pain and dexamethasone
2) Confidence 0.39 Published 2000 Journal Transfusion Section Title Doc Link 10864982 Disease Relevance 0 Pain Relevance 0.23
The anti-apoptotic protein Bcl-2 was significantly upregulated in EPO+G-CSF, EPO, and G-CSF groups, compared with control group (Fig. 4J), and the EPO+G-CSF combination induced significantly greater expression of Bcl-2 than EPO or G-CSF alone 24 hr after ischemia (Fig. 4J).
Positive_regulation (upregulated) of G-CSF associated with ischemia and apoptosis
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.43 Pain Relevance 0.20
In order to evaluate the non-hypoxic activator effect of G-CSF, the levels of activated HIF-1?
Positive_regulation (activated) of G-CSF associated with hypoxia
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.10 Pain Relevance 0
Fever (61% of patients) and bone pain (55.5% of patients) were relevant in the GM-CSF treated groups and 12 patients shifted to G-CSF.
Positive_regulation (shifted) of G-CSF associated with pain and fever
5) Confidence 0.15 Published 1999 Journal Int. J. Oncol. Section Abstract Doc Link 10402245 Disease Relevance 0.87 Pain Relevance 0.14
These two patients received G-CSF only once for each.
Positive_regulation (received) of G-CSF
6) Confidence 0.15 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475875 Disease Relevance 1.66 Pain Relevance 0.05
It has very recently been shown that the implantation of tumour cells in mice upregulates Bv8 in serum, bone marrow and spleen myeloid cells, and that G-CSF is a positive major regulator of Bv8 expression [5].
Positive_regulation (regulator) of G-CSF in myeloid cells associated with cancer
7) Confidence 0.14 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.44 Pain Relevance 0.32
We also observed increased levels of the cytokines G-CSF and, to a smaller extent, IL-6, for both the dimer and the R6K inactive mutant, indicating once again that the increased expression of these cytokines/chemokines play no role in neutrophil recruitment.
Positive_regulation (increased) of G-CSF in neutrophil associated with chemokine and cytokine
8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.11 Pain Relevance 0.43
The anti-apoptotic protein Bcl-2 was significantly upregulated in EPO+G-CSF, EPO, and G-CSF groups, compared with control group (Fig. 4J), and the EPO+G-CSF combination induced significantly greater expression of Bcl-2 than EPO or G-CSF alone 24 hr after ischemia (Fig. 4J).
Positive_regulation (upregulated) of G-CSF associated with ischemia and apoptosis
9) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.43 Pain Relevance 0.20
Additionally, significantly increased levels of IL-17, G-CSF and KC, all known neutrophil chemoattaractants, were observed in lung homogenates from protected mice compared to non-protected mice on days 3 and 7, concurrent with increased Gr-1+ cells infiltrating into the lungs.
Positive_regulation (increased) of G-CSF in lungs
10) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731172 Disease Relevance 0.70 Pain Relevance 0.51
With amniotic fluid infection, concentrations of G-CSF, IL-6 and IL-8 were elevated in all compartments (P < 0.001) but GM-CSF and IL-1 showed a significant rise only within amniotic fluid and retroplacental maternal blood (P < 0.001), a rise that was apparently not transmitted to peripheral maternal or fetal blood.
Positive_regulation (elevated) of G-CSF in amniotic fluid associated with infection
11) Confidence 0.04 Published 1995 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 8743167 Disease Relevance 0.41 Pain Relevance 0.31

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