INT6361

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 19.09
Pain Relevance 9.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
smooth muscle 2
eosinophils 2
neurons 2
macrophages 1
coronary sinus 1
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
Lasting pain 6 99.84 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 7 99.82 Very High Very High Very High
noradrenaline 3 99.80 Very High Very High Very High
Endogenous opioid 1 99.76 Very High Very High Very High
anesthesia 3 99.24 Very High Very High Very High
ischemia 28 98.72 Very High Very High Very High
Pain 109 98.60 Very High Very High Very High
analgesia 9 98.24 Very High Very High Very High
Hyperalgesia 2 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 63 99.92 Very High Very High Very High
Injury 177 99.90 Very High Very High Very High
Blister 4 99.68 Very High Very High Very High
Pain 105 99.40 Very High Very High Very High
Hypoxia 5 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 43 98.76 Very High Very High Very High
Cv Unclassified Under Development 35 98.72 Very High Very High Very High
Disorder Of Lipid Metabolism 419 98.40 Very High Very High Very High
Fibrosarcoma 4 98.40 Very High Very High Very High
Pneumonia 47 98.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm that ET-1 is released in persistent pain states and to determine which part of the CNS is involved, we measured the concentrations of ET-1 before and after inducing peripheral inflammation in different parts of the CNS involved in endogenous pain inhibitory systems in normal mice.
Localization (released) of ET-1 associated with pain, inflammation and lasting pain
1) Confidence 0.81 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664691 Disease Relevance 1.96 Pain Relevance 1.65
The results suggest that there is a basal release of ET-1 from neurons that affect baseline pain thresholds as well as an additional release during persistent pain states that acts to suppress the pain.
Localization (release) of ET-1 in neurons associated with pain and lasting pain
2) Confidence 0.81 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664691 Disease Relevance 2.27 Pain Relevance 1.68
In the present study, by means of a magnetic separation radioimmunoassay procedure, ET-1 levels were measured in 10 adult patients undergoing coronary artery bypass surgery, in 10 perioperative phases, in order to reconfirm and further elucidate the effect of cardiopulmonary bypass on endothelial secretion of ET-1.
Localization (secretion) of ET-1 in coronary artery
3) Confidence 0.70 Published 1996 Journal Cardiovasc Surg Section Abstract Doc Link 9013015 Disease Relevance 0.22 Pain Relevance 0.13
Secreted endothelial products such as endothelin-1 (ET-1), influence bone metabolism.
Localization (Secreted) of ET-1
4) Confidence 0.70 Published 2005 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 16320159 Disease Relevance 0.60 Pain Relevance 0.10
Endothelin-1 (ET-1) is a potent vasoconstrictor and mitogen secreted in response to hypoxia.
Localization (secreted) of ET-1 associated with hypoxia
5) Confidence 0.68 Published 2003 Journal Crit Care Nurs Q Section Abstract Doc Link 12930038 Disease Relevance 0.56 Pain Relevance 0.13
No changes were found in the coronary sinus; these results suggest ET-1 release from the plaque rather than an ischemia/reperfusion-related production from the distal myocardium.
Localization (release) of ET-1 in coronary sinus associated with ischemia
6) Confidence 0.67 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10569670 Disease Relevance 0.42 Pain Relevance 0.25
To assess the effects of percutaneous transluminal coronary angioplasty on endothelin-1 (ET-1) release, we assessed ET-1 concentrations at different sites of the coronary circulation in patients submitted to elective procedures.
Localization (release) of ET-1 associated with percutaneous transluminal coronary angioplasty
7) Confidence 0.67 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10569670 Disease Relevance 0.30 Pain Relevance 0.23
After endothelin-1 application, protein kinase Cepsilon immunoreactivity was observed to be translocated from the cytosol to the cell membrane in transient receptor potential V1-positive neurons.
Localization (translocated) of endothelin-1 in neurons
8) Confidence 0.62 Published 2006 Journal Neuroscience Section Abstract Doc Link 16298080 Disease Relevance 0.19 Pain Relevance 0.55
One potential algogen, the vasoconstrictive molecule endothelin-1 (ET-1), has been found to be released in high local concentrations in murine fibrosarcoma models of hyperalgesia [19], and was not seen in a non-sarcoma model (melanoma) [19].
Localization (released) of ET-1 associated with sarcoma, fibrosarcoma, hyperalgesia and skin cancer
9) Confidence 0.51 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2291052 Disease Relevance 1.41 Pain Relevance 0.73
One potential algogen, the vasoconstrictive molecule endothelin-1 (ET-1), has been found to be released in high local concentrations in murine fibrosarcoma models of hyperalgesia [19], and was not seen in a non-sarcoma model (melanoma) [19].
Localization (released) of endothelin-1 associated with sarcoma, fibrosarcoma, hyperalgesia and skin cancer
10) Confidence 0.51 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2291052 Disease Relevance 1.41 Pain Relevance 0.74
Like other secretagogues, ET-1 also stimulates K+ secretion.
Localization (secretion) of ET-1
11) Confidence 0.30 Published 1992 Journal Pflugers Arch. Section Abstract Doc Link 1326745 Disease Relevance 0 Pain Relevance 0.07
The vasoactive peptide endothelin-1 (ET-1) which is present in high concentrations in the colon, causes concentration-dependent electrogenic Cl- secretion in rabbit descending colon.
Localization (secretion) of ET-1 in descending colon
12) Confidence 0.30 Published 1992 Journal Pflugers Arch. Section Abstract Doc Link 1326745 Disease Relevance 0 Pain Relevance 0.06
ET-1-induced Cl- secretion is completely inhibited by the loop diuretic bumetanide and by indomethacin and quinacrine, inhibitors of prostaglandin synthesis.
Localization (secretion) of ET-1
13) Confidence 0.26 Published 1992 Journal Pflugers Arch. Section Abstract Doc Link 1326745 Disease Relevance 0 Pain Relevance 0.09
These findings are in contrast with those of a study where incubation of human endothelial cells cultured with HDL on a 2-chamber model system (a model reproducing the physiological state where ET-1 is released toward the underlying intimal smooth muscle in a polar fashion) inhibited the secretion of ET-1 on the opposite side of the culture on which they where applied (Unoki et al 1999), suggesting that HDL may indeed prevent the vasoconstrictor effects of ET-1.
Localization (secretion) of ET-1 in smooth muscle associated with disorder of lipid metabolism
14) Confidence 0.25 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.90 Pain Relevance 0
These findings are in contrast with those of a study where incubation of human endothelial cells cultured with HDL on a 2-chamber model system (a model reproducing the physiological state where ET-1 is released toward the underlying intimal smooth muscle in a polar fashion) inhibited the secretion of ET-1 on the opposite side of the culture on which they where applied (Unoki et al 1999), suggesting that HDL may indeed prevent the vasoconstrictor effects of ET-1.
Localization (released) of ET-1 in smooth muscle associated with disorder of lipid metabolism
15) Confidence 0.25 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.93 Pain Relevance 0
Finally, HDL was shown to modulate the synthesis of CNP, which causes vasodilatation, inhibits proliferation of smooth muscle cells, and inhibits ET-1 secretion (Sugiyama et al 1995).
Localization (secretion) of ET-1 in smooth muscle cells associated with increased venous pressure under development and disorder of lipid metabolism
16) Confidence 0.25 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.02 Pain Relevance 0
Endothelin release required intact endothelial cells.
Localization (release) of Endothelin in endothelial cells
17) Confidence 0.15 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11134653 Disease Relevance 0.20 Pain Relevance 0.20
In endothelial cells, CRP facilitated the release of PAI-1 (Devaraj et al 2003) and endothelin-1 (Verma et al 2002), and increased the expression of cell adhesion molecules (Pasceri et al 2000), reduced NO bioavailability (Venugopal et al 2002), and NO-mediated dilation in the vasculature.
Localization (release) of endothelin-1 in vasculature associated with adhesions and bioavailability
18) Confidence 0.14 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 0.27 Pain Relevance 0.09
In healthy people, insulin infusion results in the release of both NO and ET-1 in adequate concentrations to ensure an appropriate balance for maintaining vascular tone.
Localization (release) of ET-1
19) Confidence 0.14 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.84 Pain Relevance 0.25
Discriminatory power of biomarkers for predicting serious complications in CAP patients as assessed by the area under the ROC curve (AUC) ranged from 0.66 for proANP to 0.72 for proADM and proET1 (Table 1).
Localization (0.72) of proET1 associated with pneumonia
20) Confidence 0.11 Published 2010 Journal Crit Care Section Body Doc Link PMC2911752 Disease Relevance 0.34 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox