INT6362

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Context Info
Confidence 0.16
First Reported 1992
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.92
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
macrophages 2
smooth muscle 2
smooth muscle cells 2
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 87.28 High High
agonist 11 73.64 Quite High
Inflammation 25 18.52 Low Low
metalloproteinase 13 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 6 98.94 Very High Very High Very High
Disorder Of Lipid Metabolism 274 97.50 Very High Very High Very High
Adhesions 36 87.36 High High
Myocardial Infarction 6 60.24 Quite High
Cardiovascular Disease 4 54.16 Quite High
INFLAMMATION 44 50.00 Quite Low
Atherosclerotic Plaque 6 25.12 Quite Low
Apoptosis 21 5.00 Very Low Very Low Very Low
Atherosclerosis 20 5.00 Very Low Very Low Very Low
Coronary Artery Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ET-1-induced Cl- secretion is completely inhibited by the loop diuretic bumetanide and by indomethacin and quinacrine, inhibitors of prostaglandin synthesis.
Negative_regulation (inhibited) of Localization (secretion) of ET-1
1) Confidence 0.16 Published 1992 Journal Pflugers Arch. Section Abstract Doc Link 1326745 Disease Relevance 0 Pain Relevance 0.09
Finally, HDL was shown to modulate the synthesis of CNP, which causes vasodilatation, inhibits proliferation of smooth muscle cells, and inhibits ET-1 secretion (Sugiyama et al 1995).
Negative_regulation (inhibits) of Localization (secretion) of ET-1 in smooth muscle cells associated with increased venous pressure under development and disorder of lipid metabolism
2) Confidence 0.15 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.02 Pain Relevance 0
These findings are in contrast with those of a study where incubation of human endothelial cells cultured with HDL on a 2-chamber model system (a model reproducing the physiological state where ET-1 is released toward the underlying intimal smooth muscle in a polar fashion) inhibited the secretion of ET-1 on the opposite side of the culture on which they where applied (Unoki et al 1999), suggesting that HDL may indeed prevent the vasoconstrictor effects of ET-1.
Negative_regulation (inhibited) of Localization (secretion) of ET-1 in smooth muscle associated with disorder of lipid metabolism
3) Confidence 0.15 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.90 Pain Relevance 0
decreases the secretion of ET-1 from endothelial cells [112], and also inhibits the expression of NOS in macrophages [90] and vascular smooth muscle cells [113].
Negative_regulation (decreases) of Localization (secretion) of ET-1 in macrophages
4) Confidence 0.02 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0.04

General Comments

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