INT63625

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 21
Disease Relevance 3.37
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HTR4) plasma membrane (HTR4) cytoplasm (HTR4)
signal transducer activity (HTR4)
Anatomy Link Frequency
colon 5
cardiac myocytes 3
small intestine 2
myocytes 1
smooth muscle cells 1
HTR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 286 98.20 Very High Very High Very High
agonist 704 97.28 Very High Very High Very High
Serotonin 192 97.08 Very High Very High Very High
spastic colon 228 91.80 High High
fifth nerve 1 90.36 High High
tetrodotoxin 2 90.00 High High
headache 22 88.24 High High
Migraine 140 87.88 High High
abdominal pain 38 87.20 High High
antidepressant 57 80.64 Quite High
Disease Link Frequency Relevance Heat
Adenoma 19 99.66 Very High Very High Very High
Diarrhoea 19 99.48 Very High Very High Very High
Bordatella Infection 19 98.22 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

171 91.80 High High
Constipation 57 90.32 High High
Migraine Disorders 121 88.24 High High
Abdominal Pain 38 87.20 High High
Dyspepsia 19 61.20 Quite High
Depression 38 60.08 Quite High
Anxiety Disorder 57 59.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All tissues expressed 5-HT1Dbeta, 5-HT2A, 5-HT2B, 5-HT4 and 5-HT7 mRNAs.
Gene_expression (expressed) of 5-HT4
1) Confidence 0.65 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8743744 Disease Relevance 0.44 Pain Relevance 0.94
The results obtained indicate the presence of excitatory 5-HT4 receptors on cholinergic nerves within the CM of human colon.
Gene_expression (presence) of 5-HT4 in colon
2) Confidence 0.65 Published 2005 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15916624 Disease Relevance 0 Pain Relevance 0.22
More recent experiments using adenoviral expression of h5–HT4(b) and 5–HT4(d) splice variants in rodent cardiac myocytes that do not naturally express 5–HT4 receptors demonstrated that the 5–HT4(d) receptor was more efficiently coupled to adenylyl cyclase [23].
Gene_expression (expression) of HT4 in cardiac myocytes
3) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.08 Pain Relevance 0.11
Normal adrenal tissue expressed both 5–HT4(a) and 5–HT4(b) and rarely 5–HT4(d) splice variants while adrenocortical aldosterone producing adenomas increased their expression of 5–HT4(d) and no longer expressedHT4(a) or 5–HT4(b) receptor splice variants [22].
Neg (no) Gene_expression (expressed) of HT4 associated with adenoma
4) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.10 Pain Relevance 0
More recent experiments using adenoviral expression of h5–HT4(b) and 5–HT4(d) splice variants in rodent cardiac myocytes that do not naturally express 5–HT4 receptors demonstrated that the 5–HT4(d) receptor was more efficiently coupled to adenylyl cyclase [23].
Gene_expression (expression) of HT4 in cardiac myocytes
5) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.08 Pain Relevance 0.09
Interestingly, 5–HT4 receptor splice variant expression has been shown to change dramatically in cancerous tissue.
Gene_expression (expression) of HT4 receptor
6) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.08 Pain Relevance 0
Normal adrenal tissue expressed both 5–HT4(a) and 5–HT4(b) and rarely 5–HT4(d) splice variants while adrenocortical aldosterone producing adenomas increased their expression of 5–HT4(d) and no longer expressed 5–HT4(a) or 5–HT4(b) receptor splice variants [22].
Gene_expression (expression) of HT4 associated with adenoma
7) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.10 Pain Relevance 0
The current state of knowledge shows the human small intestine and colon also express h5–HT4(d) and that this is not found in other tissues [13,15,56].
Gene_expression (express) of HT4 in small intestine
8) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.06 Pain Relevance 0
More recent experiments using adenoviral expression of h5–HT4(b) and 5–HT4(d) splice variants in rodent cardiac myocytes that do not naturally express 5–HT4 receptors demonstrated that the 5–HT4(d) receptor was more efficiently coupled to adenylyl cyclase [23].
Gene_expression (expression) of HT4 in cardiac myocytes
9) Confidence 0.07 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.09 Pain Relevance 0.15
Paradoxically, 5–HT4 receptors expressed by cholinergic neurones in the human colon oppose the effect of this inhibitory postsynaptic 5–HT4 population by enhancing acetylcholine release [47].
Gene_expression (expressed) of HT4 in colon
10) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.30 Pain Relevance 0.54
Normal adrenal tissue expressed both 5–HT4(a) and 5–HT4(b) and rarely 5–HT4(d) splice variants while adrenocortical aldosterone producing adenomas increased their expression of 5–HT4(d) and no longer expressed 5–HT4(a) or 5–HT4(b) receptor splice variants [22].
Gene_expression (expressed) of HT4 associated with adenoma
11) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.10 Pain Relevance 0
Normal adrenal tissue expressed both 5–HT4(a) and 5–HT4(b) and rarely 5–HT4(d) splice variants while adrenocortical aldosterone producing adenomas increased their expression of 5–HT4(d) and no longer expressed 5–HT4(a) or 5–HT4(b) receptor splice variants [22].
Gene_expression (expressed) of HT4 associated with adenoma
12) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.10 Pain Relevance 0
However, there is a lack of quantitative data for 5–HT4 receptor splice variant expression relative to the colon to substantiate such speculations.

5–HT7 Receptors

Gene_expression (expression) of HT4 receptor in colon
13) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.23 Pain Relevance 0.23
The human small intestine and colon express various h5–HT4 splice variants (see Table 1, [13,15,56]).
Gene_expression (express) of HT4 in small intestine
14) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.15
For instance, discovery of heart-selective drugs is achievable if the heart is found to express a 5–HT4 splice variant as the therapeutic target that is unique to the heart or more prevalent to the heart than other organs.
Gene_expression (express) of HT4 in heart
15) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.05 Pain Relevance 0.21
The 5–HT4 receptor is also present in the circular smooth muscle cells of the human colon [39]. 5–HT4 agonists induce relaxation and inhibition of spontaneous contractions by activating adenylyl cyclase to increase intracellular levels of cAMP [53,54].
Gene_expression (present) of HT4 receptor in smooth muscle cells associated with agonist
16) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.51 Pain Relevance 0.75
In addition, it was shown that pertussis toxin potentiated the stimulatory effect of 5–HT on L–type Ca2+ current in rat myocytes expressing the 5–HT4(b) splice variant but not the 5–HT4(d) [23] providing further support for the suggestion that the (b) splice variant couples to both Gs and Gi/o proteins.
Gene_expression (expressing) of HT4 in myocytes associated with bordatella infection
17) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.10 Pain Relevance 0.08
Normal adrenal tissue expressed both 5–HT4(a) and 5–HT4(b) and rarely 5–HT4(d) splice variants while adrenocortical aldosterone producing adenomas increased their expression of 5–HT4(d) and no longer expressed 5–HT4(a) or 5–HT4(b) receptor splice variants [22].
Neg (no) Gene_expression (expressed) of HT4 associated with adenoma
18) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.10 Pain Relevance 0
It is possible that different 5–HT4 receptor splice variants are expressed in the various locations and so contribute to the regulation of bowel functions in different ways.
Gene_expression (expressed) of HT4 receptor in bowel
19) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.12
The current state of knowledge shows the human small intestine and colon also express h5–HT4(d) and that this is not found in other tissues [13,15,56].
Gene_expression (express) of HT4 in colon
20) Confidence 0.03 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.06 Pain Relevance 0

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