INT63627

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.79
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR7) signal transducer activity (HTR7)
Anatomy Link Frequency
trigeminal ganglia 2
saphenous vein 1
smooth muscle cells 1
superior vena cava 1
HTR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 4 98.08 Very High Very High Very High
trigeminal ganglion 2 97.40 Very High Very High Very High
Serotonin 4 97.08 Very High Very High Very High
fifth nerve 1 90.36 High High
headache 7 88.24 High High
Migraine 11 87.88 High High
Potency 2 71.16 Quite High
5HT 2 68.04 Quite High
Sumatriptan 1 65.60 Quite High
antagonist 2 54.80 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2 96.96 Very High Very High Very High
Migraine Disorders 11 88.24 High High
Cluster Headache 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When their distribution within the vessel wall was studied in more detail, it was found that capillary endothelial cells exhibited mRNA for the h5-HT1D and for the 5-HT7 receptors whereas microvascular smooth muscle cells, in addition to h5-HT1D and 5-HT7, also showed polymerase chain reaction products for h5-HT1B receptors.
Transcription (exhibited) of 5-HT7 in smooth muscle cells
1) Confidence 0.67 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0.09
All tissues expressed 5-HT1Dbeta, 5-HT2A, 5-HT2B, 5-HT4 and 5-HT7 mRNAs.
Transcription (expressed) of 5-HT7
2) Confidence 0.52 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8743744 Disease Relevance 0.44 Pain Relevance 0.94
The present study investigated, by using the method of reverse transcriptase polymerase chain reaction, whether the 5-HT7 receptor mRNA is expressed in human trigeminal ganglia.
Transcription (expressed) of 5-HT7 in trigeminal ganglia
3) Confidence 0.52 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11278099 Disease Relevance 0 Pain Relevance 0.12
5-HT7 receptor mRNA expression in human trigeminal ganglia.
Transcription (expression) of 5-HT7 in trigeminal ganglia
4) Confidence 0.52 Published 2001 Journal Neurosci. Lett. Section Title Doc Link 11278099 Disease Relevance 0 Pain Relevance 0.14
The expression of 5-HT7 receptor mRNA was observed in porcine central (cerebral cortex, trigeminal ganglion and cerebellum) as well as in peripheral (pulmonary and coronary arteries, superior vena cava and saphenous vein) tissues.
Transcription (expression) of 5-HT7 in superior vena cava associated with ganglion cysts, trigeminal ganglion and cerebral cortex
5) Confidence 0.52 Published 2002 Journal Mol. Cell. Biochem. Section Abstract Doc Link 12349912 Disease Relevance 0.18 Pain Relevance 0.37
The expression of 5-HT7 receptor mRNA was observed in porcine central (cerebral cortex, trigeminal ganglion and cerebellum) as well as in peripheral (pulmonary and coronary arteries, superior vena cava and saphenous vein) tissues.
Transcription (expression) of 5-HT7 in saphenous vein associated with ganglion cysts, trigeminal ganglion and cerebral cortex
6) Confidence 0.18 Published 2002 Journal Mol. Cell. Biochem. Section Abstract Doc Link 12349912 Disease Relevance 0.18 Pain Relevance 0.37

General Comments

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