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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.07
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr7) signal transducer activity (Htr7)
Anatomy Link Frequency
parafascicular nucleus 1
Htr7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
Lasting pain 1 99.68 Very High Very High Very High
Raphe 7 99.42 Very High Very High Very High
Spinal cord 3 99.16 Very High Very High Very High
Rostroventromedial medulla 9 98.48 Very High Very High Very High
Antinociceptive 3 95.56 Very High Very High Very High
Serotonin 5 94.32 High High
agonist 4 93.12 High High
allodynia 1 90.20 High High
Thalamus 2 89.88 High High
Disease Link Frequency Relevance Heat
Pain 8 99.68 Very High Very High Very High
Injury 1 91.24 High High
Neuropathic Pain 2 90.20 High High
Hyperalgesia 4 89.64 High High
Shock 1 84.96 Quite High
Neurogenic Inflammation 3 58.80 Quite High
Migraine Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, high concentrations (> 200 nM) may enhance neurogenic inflammation, possibly by activation of 5-HT7 receptors, which may explain lack of migraine relief and excessive injection site pain in 20-30% of patients treated with sumatriptan.

Spec (possibly) Positive_regulation (activation) of 5-HT7
1) Confidence 0.67 Published 1996 Journal Reg Anesth Section Body Doc Link 8744664 Disease Relevance 0.06 Pain Relevance 0
Activation of 5-HT1A and 5-HT7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation.
Positive_regulation (Activation) of 5-HT7 in parafascicular nucleus associated with pain
2) Confidence 0.67 Published 2005 Journal Pain Section Title Doc Link 15661450 Disease Relevance 0.17 Pain Relevance 0.48
These studies suggest that descending pain inhibitory or facilitatory pathways from RVM act ultimately in the spinal cord in acute and chronic pain states through activation of 5-HT7 and 5-HT3 receptors, respectively.
Positive_regulation (activation) of 5-HT7 in RVM associated with pain, rostroventromedial medulla, lasting pain and spinal cord
3) Confidence 0.67 Published 2009 Journal Brain Res. Section Abstract Doc Link 19427839 Disease Relevance 0.83 Pain Relevance 1.65
These findings indicate that 5-CT inhibits [3H]5-HT overflow from raphe nuclei slices of the rat by stimulation of 5-HT7 and 5-HT(1B/1D receptors, whereas the role of 5-HT1A receptors in this inhibition is less pronounced.
Positive_regulation (stimulation) of 5-HT7 associated with raphe
4) Confidence 0.45 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15260125 Disease Relevance 0 Pain Relevance 0.56

General Comments

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