INT6364

Context Info Confidence 0.78 First Reported 1991 Last Reported 2010 Negated 1 Speculated 1 Reported most in Abstract Documents 123 Total Number 124 Disease Relevance 73.76 Pain Relevance 28.43

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1) cytoplasm (Edn1)

Anatomy Link Frequency plasma 9 endothelial cells 6 tail 5 adult mouse 3 myocardium 2 Edn1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 611 100.00 Pain 212 100.00 Central nervous system 76 100.00 Central grey 10 100.00 Intracerebroventricular 7 99.98 antinociception 16 99.96 Spontaneous pain 3 99.96 intrathecal 7 99.62 Migraine 6 99.44 Antinociceptive 56 99.36

Disease Link Frequency Relevance Heat INFLAMMATION 696 100.00 Hyperoxia 378 100.00 Pain 170 100.00 Cancer 135 100.00 Urological Neuroanatomy 32 100.00 Fibrosarcoma 8 100.00 Targeted Disruption 114 99.96 Disease 1046 99.80 Disorder Of Lipid Metabolism 467 99.78 Thrombosis 66 99.70

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Intracerebroventricular endothelin-1 (ET-1) produces Ca(2+)-mediated antinociception in mice.

Gene_expression (produces) of endothelin-1 associated with antinociception and intracerebroventricular

1) Confidence 0.78 Published 1992 Journal Methods Find Exp Clin Pharmacol Section Title Doc Link 1625506 Disease Relevance 0 Pain Relevance 0.46

Intracerebroventricular endothelin-1 (ET-1) produces Ca(2+)-mediated antinociception in mice.

Gene_expression (produces) of ET-1 associated with antinociception and intracerebroventricular

2) Confidence 0.78 Published 1992 Journal Methods Find Exp Clin Pharmacol Section Title Doc Link 1625506 Disease Relevance 0 Pain Relevance 0.46

In some diseases in which endothelin-1 (ET-1) production increases (e.g. prostate cancer), ET-1 is considered to be involved in the generation of pain.

Gene_expression (production) of endothelin-1 associated with pain, disease and reprotox - general 1

3) Confidence 0.77 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838353 Disease Relevance 1.06 Pain Relevance 0.52

In some diseases in which endothelin-1 (ET-1) production increases (e.g. prostate cancer), ET-1 is considered to be involved in the generation of pain.

Gene_expression (production) of ET-1 associated with pain, disease and reprotox - general 1

4) Confidence 0.77 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838353 Disease Relevance 1.06 Pain Relevance 0.52

The aim of the study was to examine whether endothelin-1 (ET-1) injected into dorsolateral periaqueductal gray (PAG) area of mice produces antinociception.

Gene_expression (produces) of ET-1 associated with antinociception and central grey

5) Confidence 0.77 Published 1996 Journal Pain Section Abstract Doc Link 8826508 Disease Relevance 0.28 Pain Relevance 0.61

These results suggest that selective endothelin ET(A) receptor antagonists might relieve pain in patients with various diseases in which endothelin-1 production is increased, e.g. prostate cancer.

Gene_expression (production) of endothelin-1 associated with pain, antagonist, disease and reprotox - general 1

6) Confidence 0.76 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178362 Disease Relevance 1.40 Pain Relevance 0.67

In some diseases in which endothelin-1 production increases, e.g. prostate cancer, endothelin-1 is considered to be involved in the generation of pain.

Gene_expression (production) of endothelin-1 associated with pain, disease and reprotox - general 1

7) Confidence 0.76 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178362 Disease Relevance 0.81 Pain Relevance 0.37

In electrophysiological study, whole-cell patch-clamp recordings were performed to investigate the interaction of ET-1 and TRPV1 using human embryonic kidney 293 (HEK293) cells expressing endothelin type A receptor (ET(A)) and TRPV1.

Gene_expression (expressing) of endothelin in embryonic kidney

8) Confidence 0.75 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.67 Pain Relevance 0.87

Intra-tumor expression of both ET-1 mRNA and ET-1 protein were significantly upregulated compared to normal tissue, and local administration of the ET-A receptor selective antagonist, BQ-123 (100 microM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect.

Gene_expression (expression) of ET-1 protein associated with cancer, antagonist, antinociceptive and withdrawal

9) Confidence 0.74 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16807013 Disease Relevance 0.96 Pain Relevance 0.59

Intra-tumor expression of both ET-1 mRNA and ET-1 protein were significantly upregulated compared to normal tissue, and local administration of the ET-A receptor selective antagonist, BQ-123 (100 microM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect.

Gene_expression (expression) of ET-1 associated with cancer, antagonist, antinociceptive and withdrawal

10) Confidence 0.74 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16807013 Disease Relevance 0.96 Pain Relevance 0.59

Indeed, when ET-1 in a dose of 0.003 nmol, which produced significant antinociception in non-diabetic mice, it had no antinociceptive effect in diabetic mice.

Gene_expression (produced) of ET-1 associated with antinociception, diabetes mellitus and antinociceptive

11) Confidence 0.68 Published 1993 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 8451542 Disease Relevance 0.73 Pain Relevance 0.49

Endothelin-1 (ET-1) exists in endothelial cells as well as a variety of other cell types.

Gene_expression (exists) of ET-1 in endothelial cells

12) Confidence 0.68 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664691 Disease Relevance 0.59 Pain Relevance 0.49

Endothelin-1 (ET-1) exists in endothelial cells as well as a variety of other cell types.

Gene_expression (exists) of Endothelin-1 in endothelial cells

13) Confidence 0.68 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664691 Disease Relevance 0.59 Pain Relevance 0.49

The injection of endothelin-1 (ET-1) (2 pmol) into the dorsolateral periaqueductal gray area (PAG) of mice produces antinociceptive effect as underscored by increases in the latency time for the reaction to a hot plate.

Gene_expression (injection) of ET-1 associated with urological neuroanatomy, antinociceptive and central grey

14) Confidence 0.67 Published 1997 Journal Life Sci. Section Abstract Doc Link 9416772 Disease Relevance 0.35 Pain Relevance 0.38

The injection of endothelin-1 (ET-1) (2 pmol) into the dorsolateral periaqueductal gray area (PAG) of mice produces antinociceptive effect as underscored by increases in the latency time for the reaction to a hot plate.

Gene_expression (injection) of endothelin-1 associated with urological neuroanatomy, antinociceptive and central grey

15) Confidence 0.67 Published 1997 Journal Life Sci. Section Abstract Doc Link 9416772 Disease Relevance 0.35 Pain Relevance 0.37

Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine to mice antagonized the abdominal constriction induced by an i.p. injection of endothelin-1 (ET-1; 0.1 mg/kg).

Gene_expression (injection) of ET-1 associated with intracerebroventricular, morphine and intrathecal

16) Confidence 0.67 Published 1991 Journal Life Sci. Section Abstract Doc Link 1875787 Disease Relevance 0.19 Pain Relevance 0.50

Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine to mice antagonized the abdominal constriction induced by an i.p. injection of endothelin-1 (ET-1; 0.1 mg/kg).

Gene_expression (injection) of endothelin-1 associated with intracerebroventricular, morphine and intrathecal

17) Confidence 0.67 Published 1991 Journal Life Sci. Section Abstract Doc Link 1875787 Disease Relevance 0.19 Pain Relevance 0.50

The ET-1 level in the plasma was then determined by an Elisa technique (Human Endothelin Immunoassay, Catalog number QET00B, R&D Systems Inc.

Gene_expression (level) of ET-1 in plasma

18) Confidence 0.67 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.16 Pain Relevance 0.08

Measurement of ET-1 levels in blood

Gene_expression (levels) of ET-1 in blood

19) Confidence 0.67 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.24 Pain Relevance 0.06

Two groups of animals kept in room air (group C, n = 8) or were exposed to hyperoxia for 60 h (group Hox, n = 10) were not subjected to ET-1 receptor blockade, dual ETA/ETB-receptor blocker TEZ was administered continuously for 6 days via an intraperitoneal pump (10 mg/kg/day) to two other groups of mice, likewise kept in room air (group CT, n = 6) or exposed to hyperoxia for 60 h (group HoxT, n = 7).

Gene_expression (blockade) of ET-1 receptor associated with hyperoxia

20) Confidence 0.67 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.59 Pain Relevance 0

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