INT6364

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 123
Total Number 124
Disease Relevance 73.76
Pain Relevance 28.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
plasma 9
endothelial cells 6
tail 5
adult mouse 3
myocardium 2
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 611 100.00 Very High Very High Very High
Pain 212 100.00 Very High Very High Very High
Central nervous system 76 100.00 Very High Very High Very High
Central grey 10 100.00 Very High Very High Very High
Intracerebroventricular 7 99.98 Very High Very High Very High
antinociception 16 99.96 Very High Very High Very High
Spontaneous pain 3 99.96 Very High Very High Very High
intrathecal 7 99.62 Very High Very High Very High
Migraine 6 99.44 Very High Very High Very High
Antinociceptive 56 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 696 100.00 Very High Very High Very High
Hyperoxia 378 100.00 Very High Very High Very High
Pain 170 100.00 Very High Very High Very High
Cancer 135 100.00 Very High Very High Very High
Urological Neuroanatomy 32 100.00 Very High Very High Very High
Fibrosarcoma 8 100.00 Very High Very High Very High
Targeted Disruption 114 99.96 Very High Very High Very High
Disease 1046 99.80 Very High Very High Very High
Disorder Of Lipid Metabolism 467 99.78 Very High Very High Very High
Thrombosis 66 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracerebroventricular endothelin-1 (ET-1) produces Ca(2+)-mediated antinociception in mice.
Gene_expression (produces) of endothelin-1 associated with antinociception and intracerebroventricular
1) Confidence 0.78 Published 1992 Journal Methods Find Exp Clin Pharmacol Section Title Doc Link 1625506 Disease Relevance 0 Pain Relevance 0.46
Intracerebroventricular endothelin-1 (ET-1) produces Ca(2+)-mediated antinociception in mice.
Gene_expression (produces) of ET-1 associated with antinociception and intracerebroventricular
2) Confidence 0.78 Published 1992 Journal Methods Find Exp Clin Pharmacol Section Title Doc Link 1625506 Disease Relevance 0 Pain Relevance 0.46
In some diseases in which endothelin-1 (ET-1) production increases (e.g. prostate cancer), ET-1 is considered to be involved in the generation of pain.
Gene_expression (production) of endothelin-1 associated with pain, disease and reprotox - general 1
3) Confidence 0.77 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838353 Disease Relevance 1.06 Pain Relevance 0.52
In some diseases in which endothelin-1 (ET-1) production increases (e.g. prostate cancer), ET-1 is considered to be involved in the generation of pain.
Gene_expression (production) of ET-1 associated with pain, disease and reprotox - general 1
4) Confidence 0.77 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838353 Disease Relevance 1.06 Pain Relevance 0.52
The aim of the study was to examine whether endothelin-1 (ET-1) injected into dorsolateral periaqueductal gray (PAG) area of mice produces antinociception.
Gene_expression (produces) of ET-1 associated with antinociception and central grey
5) Confidence 0.77 Published 1996 Journal Pain Section Abstract Doc Link 8826508 Disease Relevance 0.28 Pain Relevance 0.61
These results suggest that selective endothelin ET(A) receptor antagonists might relieve pain in patients with various diseases in which endothelin-1 production is increased, e.g. prostate cancer.
Gene_expression (production) of endothelin-1 associated with pain, antagonist, disease and reprotox - general 1
6) Confidence 0.76 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178362 Disease Relevance 1.40 Pain Relevance 0.67
In some diseases in which endothelin-1 production increases, e.g. prostate cancer, endothelin-1 is considered to be involved in the generation of pain.
Gene_expression (production) of endothelin-1 associated with pain, disease and reprotox - general 1
7) Confidence 0.76 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178362 Disease Relevance 0.81 Pain Relevance 0.37
In electrophysiological study, whole-cell patch-clamp recordings were performed to investigate the interaction of ET-1 and TRPV1 using human embryonic kidney 293 (HEK293) cells expressing endothelin type A receptor (ET(A)) and TRPV1.
Gene_expression (expressing) of endothelin in embryonic kidney
8) Confidence 0.75 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.67 Pain Relevance 0.87
Intra-tumor expression of both ET-1 mRNA and ET-1 protein were significantly upregulated compared to normal tissue, and local administration of the ET-A receptor selective antagonist, BQ-123 (100 microM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect.
Gene_expression (expression) of ET-1 protein associated with cancer, antagonist, antinociceptive and withdrawal
9) Confidence 0.74 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16807013 Disease Relevance 0.96 Pain Relevance 0.59
Intra-tumor expression of both ET-1 mRNA and ET-1 protein were significantly upregulated compared to normal tissue, and local administration of the ET-A receptor selective antagonist, BQ-123 (100 microM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect.
Gene_expression (expression) of ET-1 associated with cancer, antagonist, antinociceptive and withdrawal
10) Confidence 0.74 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16807013 Disease Relevance 0.96 Pain Relevance 0.59
Indeed, when ET-1 in a dose of 0.003 nmol, which produced significant antinociception in non-diabetic mice, it had no antinociceptive effect in diabetic mice.
Gene_expression (produced) of ET-1 associated with antinociception, diabetes mellitus and antinociceptive
11) Confidence 0.68 Published 1993 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 8451542 Disease Relevance 0.73 Pain Relevance 0.49
Endothelin-1 (ET-1) exists in endothelial cells as well as a variety of other cell types.
Gene_expression (exists) of ET-1 in endothelial cells
12) Confidence 0.68 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664691 Disease Relevance 0.59 Pain Relevance 0.49
Endothelin-1 (ET-1) exists in endothelial cells as well as a variety of other cell types.
Gene_expression (exists) of Endothelin-1 in endothelial cells
13) Confidence 0.68 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664691 Disease Relevance 0.59 Pain Relevance 0.49
The injection of endothelin-1 (ET-1) (2 pmol) into the dorsolateral periaqueductal gray area (PAG) of mice produces antinociceptive effect as underscored by increases in the latency time for the reaction to a hot plate.
Gene_expression (injection) of ET-1 associated with urological neuroanatomy, antinociceptive and central grey
14) Confidence 0.67 Published 1997 Journal Life Sci. Section Abstract Doc Link 9416772 Disease Relevance 0.35 Pain Relevance 0.38
The injection of endothelin-1 (ET-1) (2 pmol) into the dorsolateral periaqueductal gray area (PAG) of mice produces antinociceptive effect as underscored by increases in the latency time for the reaction to a hot plate.
Gene_expression (injection) of endothelin-1 associated with urological neuroanatomy, antinociceptive and central grey
15) Confidence 0.67 Published 1997 Journal Life Sci. Section Abstract Doc Link 9416772 Disease Relevance 0.35 Pain Relevance 0.37
Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine to mice antagonized the abdominal constriction induced by an i.p. injection of endothelin-1 (ET-1; 0.1 mg/kg).
Gene_expression (injection) of ET-1 associated with intracerebroventricular, morphine and intrathecal
16) Confidence 0.67 Published 1991 Journal Life Sci. Section Abstract Doc Link 1875787 Disease Relevance 0.19 Pain Relevance 0.50
Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine to mice antagonized the abdominal constriction induced by an i.p. injection of endothelin-1 (ET-1; 0.1 mg/kg).
Gene_expression (injection) of endothelin-1 associated with intracerebroventricular, morphine and intrathecal
17) Confidence 0.67 Published 1991 Journal Life Sci. Section Abstract Doc Link 1875787 Disease Relevance 0.19 Pain Relevance 0.50
The ET-1 level in the plasma was then determined by an Elisa technique (Human Endothelin Immunoassay, Catalog number QET00B, R&D Systems Inc.
Gene_expression (level) of ET-1 in plasma
18) Confidence 0.67 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.16 Pain Relevance 0.08
Measurement of ET-1 levels in blood
Gene_expression (levels) of ET-1 in blood
19) Confidence 0.67 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.24 Pain Relevance 0.06
Two groups of animals kept in room air (group C, n = 8) or were exposed to hyperoxia for 60 h (group Hox, n = 10) were not subjected to ET-1 receptor blockade, dual ETA/ETB-receptor blocker TEZ was administered continuously for 6 days via an intraperitoneal pump (10 mg/kg/day) to two other groups of mice, likewise kept in room air (group CT, n = 6) or exposed to hyperoxia for 60 h (group HoxT, n = 7).
Gene_expression (blockade) of ET-1 receptor associated with hyperoxia
20) Confidence 0.67 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.59 Pain Relevance 0

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