INT63640

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 2
Total Number 36
Disease Relevance 31.15
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SELENBP1) nucleolus (SELENBP1) nucleus (SELENBP1)
cytoplasm (SELENBP1)
Anatomy Link Frequency
uterine 11
myometrium 8
colon 2
lungs 2
endometrium 1
SELENBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 1 78.84 Quite High
pain pelvic 35 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 2660 99.84 Very High Very High Very High
Cancer 945 99.68 Very High Very High Very High
Ovarian Cancer 35 99.16 Very High Very High Very High
Adenocarcinoma 35 98.58 Very High Very High Very High
Apoptosis 35 95.80 Very High Very High Very High
Colon Cancer 35 95.28 Very High Very High Very High
Endometriosis (extended) 35 87.04 High High
Breast Cancer 35 85.44 High High
Stomach Cancer 1 81.16 Quite High
Disease 2 78.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, decreased expression of SELENBP1 in even the smallest leiomyoma (i.e., 1 cm) examined suggests that alteration in SELENBP1 expression may be an early event in the development of the tumor.
Spec (examined) Gene_expression (expression) of SELENBP1 associated with uterine fibroids and cancer
1) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.21 Pain Relevance 0
While no previous report has addressed the relationship between vascular count and SELENBP1 expression in any tumor, we showed that vascular count was not correlated with SELENBP1 expression in uterine leiomyomas.
Gene_expression (expression) of SELENBP1 in uterine associated with uterine fibroids and cancer
2) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.87 Pain Relevance 0
While no previous report has addressed the relationship between vascular count and SELENBP1 expression in any tumor, we showed that vascular count was not correlated with SELENBP1 expression in uterine leiomyomas.
Gene_expression (expression) of SELENBP1 in uterine associated with uterine fibroids and cancer
3) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.85 Pain Relevance 0
Indeed, decreased expression of SELENBP1 in even the smallest leiomyoma (i.e., 1 cm) examined suggests that alteration in SELENBP1 expression may be an early event in the development of the tumor.
Gene_expression (expression) of SELENBP1 associated with uterine fibroids and cancer
4) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.21 Pain Relevance 0
Using a monoclonal antibody against human SELENBP1 (Medical Biological Laboratory International Corporation, Watertown, MA), we evaluated the expression of SELENBP1 by Western Blot and immunohistochemistry.
Gene_expression (expression) of SELENBP1
5) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.91 Pain Relevance 0
The expression of SELENBP1 has been shown to be decreased in several tumors including cancers of the prostate, lungs, colon, and ovary [23-26].
Gene_expression (expression) of SELENBP1 in colon associated with cancer
6) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.15 Pain Relevance 0
Our study showing a decreased expression of SELENBP1 in uterine leiomyoma not only indicates a role of SELENBP1 in tumorigenesis but also suggests the potential utility of selenium in prevention and treatment of uterine leiomyoma.
Gene_expression (expression) of SELENBP1 in uterine associated with uterine fibroids
7) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.14 Pain Relevance 0
It is likely that additional genetic and molecular events contribute to tumorigenesis, but reduction of SELENBP1 expression may be a key step in the transition from normal myometrium to leiomyoma.
Gene_expression (expression) of SELENBP1 in myometrium associated with uterine fibroids
8) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.19 Pain Relevance 0
In myometrium showing normal expression of SELENBP1, selenium may be able to disrupt estrogen signaling pathway.
Gene_expression (expression) of SELENBP1 in myometrium
9) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.64 Pain Relevance 0
A negative correlation between SELENBP1 expression and Ki67 positivity has been reported in lung adenocarcinomas [24], but our study did not reveal a significant relationship between SELENBP1 expression and proliferation index in uterine leiomyomas.
Gene_expression (expression) of SELENBP1 in uterine associated with adenocarcinoma and uterine fibroids
10) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.59 Pain Relevance 0
It has been reported, however, that treating ovarian tumor cells with a selenium compound increases SELENBP1 expression [35].
Gene_expression (expression) of SELENBP1 associated with ovarian cancer
11) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.00 Pain Relevance 0
SELENBP1 expression did not differ among patients with proliferative, secretory, and atrophic endometrium either in normal myometrium or leiomyoma (Figure 4), but leiomyoma showed a significantly lower level of SELENBP1 than normal myometrium either in patients with proliferative endometrium, in patients with secretory endometrium, or in patients with atrophic endometrium.
Gene_expression (expression) of SELENBP1 in endometrium associated with uterine fibroids
12) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.95 Pain Relevance 0
When the expression of SELENBP1 is reduced, however, leiomyoma may develop because selenium without adequate SELENBP1 may be incapable of inhibiting the stimulatory actions of estrogens.
Gene_expression (expression) of SELENBP1 associated with uterine fibroids
13) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.62 Pain Relevance 0
A negative correlation between SELENBP1 expression and Ki67 positivity has been reported in lung adenocarcinomas [24], but our study did not reveal a significant relationship between SELENBP1 expression and proliferation index in uterine leiomyomas.
Gene_expression (expression) of SELENBP1 in uterine associated with adenocarcinoma and uterine fibroids
14) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.75 Pain Relevance 0
Since the effects of selenium are mediated by SELENBP1, loss of SELENBP1 expression in leiomyoma may have a negative impact on the ability of selenium to control tumor cell growth.
Gene_expression (expression) of SELENBP1 associated with uterine fibroids and cancer
15) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.13 Pain Relevance 0
In this study, we examined the expression of SELENBP1 in uterine leiomyoma and normal myometrium.


Spec (examined) Gene_expression (expression) of SELENBP1 in myometrium associated with uterine fibroids
16) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 1.14 Pain Relevance 0
Wilcoxon Matched-Pair Signed-Ranks test was used to compare the expression of SELENBP1 between leiomyoma and normal myometrium.
Gene_expression (expression) of SELENBP1 in myometrium associated with uterine fibroids
17) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.73 Pain Relevance 0
Although there was a trend for a decreased expression of SELENBP1 with increasing tumor size (Figure 2), no statistical difference was seen among four arbitrary size groups: ?
Gene_expression (expression) of SELENBP1 associated with cancer
18) Confidence 0.78 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.84 Pain Relevance 0
Our study demonstrated similar levels of SELENBP1 among patients with proliferative, secretory, and atrophic endometrium in either normal myometrium or leiomyoma, indicating that SELENBP1 is not regulated by sex hormones.
Gene_expression (levels) of SELENBP1 in myometrium associated with uterine fibroids
19) Confidence 0.67 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.35 Pain Relevance 0
The levels of SELENBP1 did not differ between patients younger than 45 years and older patients in either normal myometrium or leiomyoma (Figure 3).
Gene_expression (levels) of SELENBP1 in myometrium associated with uterine fibroids
20) Confidence 0.67 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3014888 Disease Relevance 0.85 Pain Relevance 0

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