INT6365

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Context Info
Confidence 0.81
First Reported 1992
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 56
Total Number 59
Disease Relevance 18.84
Pain Relevance 13.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
endothelial cells 4
plasma 3
pituitary gland 3
smooth muscle 2
body 2
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 136 100.00 Very High Very High Very High
Neuropeptide 26 100.00 Very High Very High Very High
metalloproteinase 15 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
Enkephalin 8 99.92 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 6 99.92 Very High Very High Very High
Neurotransmitter 40 99.84 Very High Very High Very High
Opioid 13 99.84 Very High Very High Very High
Pain 121 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 115 99.92 Very High Very High Very High
Hypoxia 8 99.92 Very High Very High Very High
Intestinal Obstruction 2 99.88 Very High Very High Very High
Atherosclerotic Plaque 2 99.76 Very High Very High Very High
Primary Sclerosing Cholangitis 6 99.72 Very High Very High Very High
Cancer 86 99.52 Very High Very High Very High
Nociception 90 99.40 Very High Very High Very High
Sepsis 14 99.36 Very High Very High Very High
Cancer Pain 20 99.16 Very High Very High Very High
Injury 52 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined whether endothelin-1 (ET-1), a potent vasoconstrictive peptide secreted in high concentration by metastatic prostate cancer cells, produces endothelin receptor-dependent pain behavior when applied to rat sciatic nerve.
Localization (secreted) of endothelin-1 in sciatic nerve associated with pain, sciatic nerve and reprotox - general 1
1) Confidence 0.81 Published 1998 Journal Neuroreport Section Abstract Doc Link 9694215 Disease Relevance 0.34 Pain Relevance 0.50
We examined whether endothelin-1 (ET-1), a potent vasoconstrictive peptide secreted in high concentration by metastatic prostate cancer cells, produces endothelin receptor-dependent pain behavior when applied to rat sciatic nerve.
Localization (secreted) of ET-1 in sciatic nerve associated with pain, sciatic nerve and reprotox - general 1
2) Confidence 0.81 Published 1998 Journal Neuroreport Section Abstract Doc Link 9694215 Disease Relevance 0.34 Pain Relevance 0.50
Are mu-opioid receptors involved in the control of endothelin-1 release from the pituitary gland in normal and dehydrated rats?
Localization (release) of endothelin-1 in pituitary gland associated with mu opioid receptor
3) Confidence 0.81 Published 1997 Journal Regul. Pept. Section Title Doc Link 9178351 Disease Relevance 0.06 Pain Relevance 0.19
The objective of the present study was to investigate whether the endogenous opioids are involved in the control of endothelin-1 release from the pituitary gland.
Localization (release) of endothelin-1 in pituitary gland associated with endogenous opioid
4) Confidence 0.81 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178351 Disease Relevance 0 Pain Relevance 0.18
CONCLUSIONS: (1) An elevation of irET-1 in the pituitary gland and peripheral circulation in dehydrated animals may play a role in maintaining of water-electrolyte balance. (2) The mu-opioid system appears to control the ET-1 release from the pituitary in normal and dehydrated animals.
Localization (release) of ET-1 in pituitary gland associated with opioid
5) Confidence 0.81 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178351 Disease Relevance 0.07 Pain Relevance 0.16
Endothelin-1 (ET-1) is a chemical mediator released by the body at sites of injury and disease.
Localization (released) of ET-1 in body associated with injury and disease
6) Confidence 0.81 Published 2007 Journal J Pain Section Abstract Doc Link 17553749 Disease Relevance 0.44 Pain Relevance 0
Endothelin-1 (ET-1) is a chemical mediator released by the body at sites of injury and disease.
Localization (released) of Endothelin-1 in body associated with injury and disease
7) Confidence 0.81 Published 2007 Journal J Pain Section Abstract Doc Link 17553749 Disease Relevance 0.44 Pain Relevance 0
PERSPECTIVE: Endothelin-1 is a vasoactive peptide released into the systemic circulation after stress and cold pain as well as locally in tissue after injury and disease.
Localization (released) of Endothelin-1 associated with stress, pain, injury and disease
8) Confidence 0.81 Published 2007 Journal J Pain Section Abstract Doc Link 17553749 Disease Relevance 1.53 Pain Relevance 0.66
This means that only about 6 pmol of ET-1 was released subcutaneously each minute.
Localization (released) of ET-1
9) Confidence 0.81 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004627 Disease Relevance 0.07 Pain Relevance 0.04
One such mediator, endothelin-1 (ET-1) is secreted by different tumor types.
Localization (secreted) of ET-1 associated with cancer
10) Confidence 0.81 Published 2009 Journal Journal of pain research Section Abstract Doc Link PMC3004627 Disease Relevance 0.62 Pain Relevance 0.19
One such mediator, endothelin-1 (ET-1) is secreted by different tumor types.
Localization (secreted) of endothelin-1 associated with cancer
11) Confidence 0.81 Published 2009 Journal Journal of pain research Section Abstract Doc Link PMC3004627 Disease Relevance 0.62 Pain Relevance 0.19
ET-1 is indeed released from endothelial cells in a polarized fashion into the direction of surrounding vascular tissue and thus, plasma levels of ET-1 are likely to be only a fraction of the levels in surrounding tissues and should perhaps be considered as a merely “spill over” from the tissue compartment.
Localization (released) of ET-1 in plasma
12) Confidence 0.81 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004627 Disease Relevance 0.67 Pain Relevance 0.21
ET-1 concentration was significantly higher in portal venous than in aortic blood, indicating net nonhepatic splanchnic release (nNHSR) of ET-1.
Localization (release) of ET-1 in blood
13) Confidence 0.81 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15471983 Disease Relevance 0.31 Pain Relevance 0
Endothelin-1-like immunoreactivity was localized predominantly to islet cells both in normal subjects and in patients with chronic pancreatitis.
Localization (localized) of Endothelin-1-like associated with chronic pancreatitis
14) Confidence 0.80 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8778321 Disease Relevance 0.84 Pain Relevance 0.65
This slow increase in the plasma level in spite of a high local concentration could, in part, be due to the fact that ET-1 is secreted from the abluminal surface of the endothelial cells [40].
Localization (secreted) of ET-1 in endothelial cells
15) Confidence 0.78 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0 Pain Relevance 0.03
As suggested by recent investigators, competition at the receptor between ET-1 and its antagonists could result in release of ET-1 from the receptor, thereby contributing to an overall increase in the plasma concentration consistent with the present findings [43].
Localization (release) of ET-1 in plasma associated with antagonist
16) Confidence 0.78 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.25 Pain Relevance 0.05
The localization of endothelin (ET) in perivascular nerve varicosities supports pharmacological evidence that ET is a neurotransmitter in the autonomic nervous system.
Localization (localization) of endothelin in nerve associated with neurotransmitter and increased venous pressure under development
17) Confidence 0.78 Published 2000 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 11154842 Disease Relevance 0.10 Pain Relevance 0.05
CONCLUSION: Bupivacaine and ropivacaine attenuated N-formyl-L-leucine-methionyl-L-phenylalanine-induced PAP, reduced lung edema, and diminished ET-1 release.
Localization (release) of ET-1 in lung
18) Confidence 0.76 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690261 Disease Relevance 0 Pain Relevance 0
We examined the effects of procaine, bupivacaine, and ropivacaine on experimentally evoked PAP increase and ET-1 release.
Localization (release) of ET-1
19) Confidence 0.76 Published 2009 Journal Anesth. Analg. Section Abstract Doc Link 19690261 Disease Relevance 0.35 Pain Relevance 0.17
Influence of endothelin-1 on cholinergic nerve-mediated contractions and acetylcholine release in rat isolated tracheal smooth muscle.
Localization (release) of endothelin-1 in smooth muscle
20) Confidence 0.75 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8968335 Disease Relevance 0 Pain Relevance 0.15

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