INT63651

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Context Info
Confidence 0.77
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 2.57
Pain Relevance 4.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Adcyap1r1) endosome (Adcyap1r1) signal transduction (Adcyap1r1)
plasma membrane (Adcyap1r1) cytoplasm (Adcyap1r1) signal transducer activity (Adcyap1r1)
Anatomy Link Frequency
pituitary 4
neurons 3
nucleus accumbens 1
locus coeruleus 1
Adcyap1r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 1 100.00 Very High Very High Very High
Peripheral nervous system 4 99.48 Very High Very High Very High
withdrawal 16 99.28 Very High Very High Very High
Morphine 17 99.06 Very High Very High Very High
Nucleus accumbens 1 99.04 Very High Very High Very High
Neuropeptide 29 98.90 Very High Very High Very High
nociceptor 4 98.90 Very High Very High Very High
medulla 4 98.24 Very High Very High Very High
Locus ceruleus 16 97.04 Very High Very High Very High
Glutamate 115 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 42 99.52 Very High Very High Very High
Cancer 1 99.36 Very High Very High Very High
Repression 201 95.24 Very High Very High Very High
Pain 12 93.08 High High
Opiate Addiction 4 92.28 High High
Disease 4 82.20 Quite High
Brain Injury 1 81.20 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 78.52 Quite High
Death 18 72.96 Quite High
INFLAMMATION 17 51.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pituitary adenylate cyclase-activating polypeptide type I-receptor (PAC1) is a G-protein-coupled receptor that is widely expressed in neurons of the central and peripheral nervous system.
Gene_expression (expressed) of PAC1 in pituitary associated with peripheral nervous system
1) Confidence 0.77 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12573539 Disease Relevance 0.22 Pain Relevance 0.58
The strong expression of PAC1 in the second sensory neuron as well as in brainstem regions such as the locus coeruleus prompted us to elucidate the potential in vivo role of PAC1-mediated signalling in pain perception and opioid addiction using a PAC1-deficient mouse line.
Gene_expression (expression) of PAC1 in locus coeruleus associated with addiction, pain, medulla, locus ceruleus and opioid
2) Confidence 0.77 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12573539 Disease Relevance 0.31 Pain Relevance 0.69
The pituitary adenylate cyclase-activating polypeptide type I-receptor (PAC1) is a G-protein-coupled receptor that is widely expressed in neurons of the central and peripheral nervous system.
Gene_expression (expressed) of cyclase-activating polypeptide type I-receptor in pituitary associated with peripheral nervous system
3) Confidence 0.67 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12573539 Disease Relevance 0.22 Pain Relevance 0.58
RATIONALE: The neuropeptide pituitary adenylyl cyclase-activating peptide (PACAP) and its receptors (PAC1 and VPAC2) are expressed in the ventral tegmental area and nucleus accumbens, raising the possibility that PACAP could be a potential modulator of the mesolimbic dopaminergic system.
Gene_expression (expressed) of PAC1 in nucleus accumbens associated with nucleus accumbens, ventral tegmentum and neuropeptide
4) Confidence 0.55 Published 2009 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 19199096 Disease Relevance 0 Pain Relevance 0.22
Morphine withdrawal is modified in pituitary adenylate cyclase-activating polypeptide type I-receptor-deficient mice.
Gene_expression (deficient) of cyclase-activating polypeptide type I-receptor in pituitary associated with withdrawal and morphine
5) Confidence 0.52 Published 2003 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 12573539 Disease Relevance 0.31 Pain Relevance 1.13
Notably, Adcyap1r1 exon 14 was the only exon tested that did not contain one of the eight-nucleotide CaRRE sequences used in the search, but was repressed after depolarization.
Gene_expression (exon) of Adcyap1r1
6) Confidence 0.30 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.22 Pain Relevance 0
The one exception was Adcyap1r1 exon 14, which is discussed below (Figure 7A and 7B, group 2).
Gene_expression (exon) of Adcyap1r1
7) Confidence 0.26 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.05 Pain Relevance 0
The GenBank (http://www.ncbi.nlm.nih.gov/Genbank/) RefSeq accession numbers for the genes discussed in this paper are as follows: Adcyap1r1 (NM_001025372.1), Atp2b1 (NM_026482.1), D4Ertd22e (NM_174996.2), Dnalc4 (NM_017470.1), Gtl3 (NM_008187.1), Ilf3 (NM_001042708.1), Ktn1 (NM_008477.1), Nf2 (NM_010898.2), Pitpnb (NM_019640.2), Rabggtb (NM_011231.1), Rnf14 (NM_020012.1), Samhd1 (NM_018851.2), Shc1 (NM_011368.3), Spna2 (NM_001076554.1), Timm22 (NM_019818.2), U26 (NM_173765.1), and Xpo4 (NM_020506.1).



Gene_expression (follows) of Adcyap1r1
8) Confidence 0.26 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0 Pain Relevance 0
A PCR analys is of the mRNA isolated from the rat SCN found evidence for the expression of two PAC1 isoforms including the PAC1null splice variant [47].
Gene_expression (expression) of PAC1
9) Confidence 0.22 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.16
A PCR analys is of the mRNA isolated from the rat SCN found evidence for the expression of two PAC1 isoforms including the PAC1null splice variant [47].
Gene_expression (expression) of PAC1null
10) Confidence 0.19 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.16
Both PAC1 and VPAC2 mRNAs are expressed within the rat SCN [12-15].
Gene_expression (expressed) of PAC1
11) Confidence 0.19 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.20
Light stimulation in the early night resulted in larger phase delays in PAC1 -/- mice accompanied by a reduction in light-induced mPer and c-Fos expression [21].
Gene_expression (expression) of PAC1
12) Confidence 0.19 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.08
PACAP-like immunoreactivity is found in terminals of retinal ganglion neurons innervating the SCN [10,11] and two of the receptors sensitive to PACAP (PAC1 and VPAC2) are expressed in the SCN [12-15].
Gene_expression (expressed) of PAC1 in neurons associated with ganglion cysts
13) Confidence 0.19 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0.16 Pain Relevance 0.23
Interestingly, the PAC1 receptor mRNA and protein are expressed in retinal ganglion cells [35] and may thus be in the neurons that form the RHT.
Gene_expression (expressed) of PAC1 receptor in neurons associated with ganglion cysts
14) Confidence 0.17 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0.10 Pain Relevance 0.13
First, our finding that PACAP increases sEPSC frequency and the anatomical finding that PAC1 receptors are expressed in retinal ganglion cells [35] raises the possibility that PACAP may act presynaptically to regulate the release of glutamate onto SCN neurons.
Gene_expression (expressed) of PAC1 in neurons associated with ganglion cysts and glutamate
15) Confidence 0.17 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0.10 Pain Relevance 0.05
PACAP binds to its high-affinity PAC1 receptor that is expressed by different target cells [33], [34], including NPCs [27].
Gene_expression (expressed) of PAC1 receptor
16) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.49 Pain Relevance 0.11
High levels of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor mRNA expression in primary and tumor lymphoid cells.
Gene_expression (expression) of cyclase-activating peptide receptor mRNA in pituitary associated with cancer
17) Confidence 0.05 Published 1995 Journal Regul. Pept. Section Title Doc Link 8746541 Disease Relevance 0.10 Pain Relevance 0.26

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