INT63671

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Context Info
Confidence 0.38
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 1.68

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cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 20 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 4 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At concentrations of lobenzarit of 0.2 and 0.3 mM, added 30 min before paracetamol, the drug prevented paracetamol-induced leakage of lactate dehydrogenase (LDH) almost completely and lipid peroxidation (LPO) and depletion of glutathione (GSH) substantially and also the formation of the 3-glutathionyl conjugate of paracetamol.
Negative_regulation (prevented) of Protein_catabolism (leakage) of lactate dehydrogenase associated with paracetamol
1) Confidence 0.38 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8748682 Disease Relevance 0.15 Pain Relevance 0.84
At concentrations of lobenzarit of 0.2 and 0.3 mM, added 30 min before paracetamol, the drug prevented paracetamol-induced leakage of lactate dehydrogenase (LDH) almost completely and lipid peroxidation (LPO) and depletion of glutathione (GSH) substantially and also the formation of the 3-glutathionyl conjugate of paracetamol.
Negative_regulation (prevented) of Protein_catabolism (leakage) of LDH associated with paracetamol
2) Confidence 0.38 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8748682 Disease Relevance 0.15 Pain Relevance 0.84

General Comments

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