INT63672

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.07
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt2b1)
Anatomy Link Frequency
liver 2
kidney 1
Kupffer cell 1
Ugt2b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 16 98.88 Very High Very High Very High
Morphine 4 94.76 High High
Opioid 1 92.56 High High
anesthesia 4 77.28 Quite High
tetrodotoxin 1 74.32 Quite High
agonist 1 69.64 Quite High
Bile 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 4 91.68 High High
Injury 7 90.48 High High
Increased Venous Pressure Under Development 2 86.16 High High
Necrosis 1 80.16 Quite High
Acute-phase Reaction 2 75.00 Quite High
Hepatotoxicity 1 63.80 Quite High
Stress Incontinence 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other CYP isozyme selective inhibitors, such as metyrapone (CYP 2B), 7-pentoxyresorufin (CYP 2B1), sulfaphenazole (CYP 2C/3A), and 17-octadecynoic acid (4A-linked omega-hydroxylase inhibitor), did not alter ACh or histamine-induced EDHF response.
Negative_regulation (inhibitors) of 2B1
1) Confidence 0.57 Published 1997 Journal Am. J. Hypertens. Section Abstract Doc Link 9234831 Disease Relevance 0.14 Pain Relevance 0.11
Although we observed the expression of other UGT isoforms, such as UGT1A1, UGT1A6, and UGT1A7, in the fetus (Figure 6C), the results of the UGT activity assay strongly suggested that the fetus has low ability to metabolize BPA due to a deficiency in UGT2B1.
Negative_regulation (deficiency) of UGT2B1
2) Confidence 0.53 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.09
Endotoxin administration was associated with a time-dependent decrease in UGT1A1, UGT1A6, UGT2B1, and UGT2B3 mRNA levels in liver and kidney tissues.
Negative_regulation (decrease) of UGT2B1 in kidney
3) Confidence 0.53 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.31
The level of CYP 2B1 activity was decreased by Kupffer cell inactivation, but not by FFx.
Neg (not) Negative_regulation (decreased) of 2B1 in Kupffer cell
4) Confidence 0.42 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 12568358 Disease Relevance 0.30 Pain Relevance 0.15
Lobenzarit did not inhibit cytochromes P-450 1A1/1A2, 2B1/2B2 and 2E1 which were measured as ethoxyresorufin O-deethylation (EROD) activity in beta-naphthoflavone-induced rat liver microsomes, as pentoxyresorufin de-pentylation (PROD) activity in phenobarbital-induced microsomes and as p-nitrophenol hydroxylation (PNPH) activity in pyrazol-induced microsomes.
Negative_regulation (inhibit) of 2B1 in liver
5) Confidence 0.41 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8748682 Disease Relevance 0.17 Pain Relevance 0.79
On the other hand, in mice treated with PP (10 and 25 mg/kg, p.o.), the activities of P4501A2, 2B1, 3A4 and 2E1 were dramatically inhibited, and the activity of PST was significantly enhanced.
Negative_regulation (inhibited) of 2B1
6) Confidence 0.41 Published 2003 Journal Phytother Res Section Abstract Doc Link 12672155 Disease Relevance 0.31 Pain Relevance 0.13
Endotoxin administration was associated with a time-dependent decrease in UGT1A1, UGT1A6, UGT2B1, and UGT2B3 mRNA levels in liver and kidney tissues.
Negative_regulation (decrease) of UGT2B1 in liver
7) Confidence 0.18 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.31

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