INT63673

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.91
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
lymphocytes 2
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 1 100.00 Very High Very High Very High
Paracetamol 10 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lymphopenia 1 100.00 Very High Very High Very High
Fatigue 1 100.00 Very High Very High Very High
Thrombocytopenia 1 100.00 Very High Very High Very High
Headache 1 100.00 Very High Very High Very High
Chills 1 100.00 Very High Very High Very High
Fever 1 100.00 Very High Very High Very High
Malaria 1 99.88 Very High Very High Very High
Babesiosis 8 99.22 Very High Very High Very High
Heart Rate Under Development 6 77.60 Quite High
Toxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paracetamol was selected as a model toxin, since it is known to be bioactivated by specific cytochrome P-450s presumably to N-acetyl-p-benzoquinoneimine, a reactive metabolite which upon overdosage of paracetamol causes protein and non-protein thiol depletion, lipid peroxidation and cytotoxicity measurable as LDH leakage.
Positive_regulation (causes) of LDH Binding (leakage) of associated with paracetamol
1) Confidence 0.44 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8748682 Disease Relevance 0.14 Pain Relevance 0.80
Babesiosis presents clinically as a malaria-like illness with fever, chills, headache, fatigue with lymphopenia, atypical lymphocytes, mildly or transiently elevated serum transaminases, thrombocytopenia, and increased lactate dehydrogenase (LDH) levels.
Positive_regulation (increased) of LDH Binding (illness) of in lymphocytes associated with babesiosis, fever, malaria, lymphopenia, chills, headache, fatigue and thrombocytopenia
2) Confidence 0.27 Published 2007 Journal Eur. J. Clin. Microbiol. Infect. Dis. Section Abstract Doc Link 17558489 Disease Relevance 1.77 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox