INT637

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Context Info
Confidence 0.67
First Reported 1977
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 23
Total Number 25
Disease Relevance 21.13
Pain Relevance 9.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (MRAP) plasma membrane (MRAP) cytoplasm (MRAP)
Anatomy Link Frequency
B35 1
liver 1
Reiter 1
MRAP (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 107 100.00 Very High Very High Very High
Crohn's disease 5 99.96 Very High Very High Very High
Neuritis 9 99.84 Very High Very High Very High
Arthritis 147 99.76 Very High Very High Very High
rheumatoid arthritis 45 99.76 Very High Very High Very High
Inflammation 40 99.48 Very High Very High Very High
psoriasis 36 98.60 Very High Very High Very High
spondylitis 5 98.38 Very High Very High Very High
backache 6 96.72 Very High Very High Very High
Osteoarthritis 2 91.40 High High
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 155 100.00 Very High Very High Very High
Low Back Pain 94 100.00 Very High Very High Very High
Disease 46 99.96 Very High Very High Very High
Arthropathy 13 99.92 Very High Very High Very High
Optic Neuritis 9 99.84 Very High Very High Very High
Hyperplasia 3 99.84 Very High Very High Very High
Rheumatoid Arthritis 47 99.76 Very High Very High Very High
INFLAMMATION 36 99.48 Very High Very High Very High
Pancytopenia 1 99.48 Very High Very High Very High
Syndrome 19 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased frequency of the HLA phenotype B27,B44.
Positive_regulation (Increased) of B27
1) Confidence 0.67 Published 1988 Journal J. Rheumatol. Section Title Doc Link 3266250 Disease Relevance 0.75 Pain Relevance 0.72
Only the group with axial disease sacroiliitis+spondylitis) without peripheral arthritis and not fulfilling the NY criteria showed a truly increased B27 prevalence.
Positive_regulation (increased) of B27 associated with sacroiliitis, spondylitis, disease and arthritis
2) Confidence 0.59 Published 1994 Journal Acta Derm Venereol Suppl (Stockh) Section Abstract Doc Link 8073845 Disease Relevance 1.16 Pain Relevance 0.28
Three of the 12 seronegative arthritis patients (without clinical or radiological evidence of sacro-iliitis) had elevated values: all of these were positive for HL-A B27.
Positive_regulation (positive) of B27 associated with arthritis
3) Confidence 0.50 Published 1979 Journal Rheumatol Rehabil Section Abstract Doc Link 158822 Disease Relevance 0.70 Pain Relevance 0.48
[Study of a population carrying HLA B27 antigen compared with a population without B27, in the detection of ankylosing spondylitis].
Positive_regulation (carrying) of B27 associated with seronegative spondarthritis and spinal inflammation
4) Confidence 0.50 Published 1978 Journal Rev Rhum Mal Osteoartic Section Title Doc Link 150017 Disease Relevance 0.44 Pain Relevance 0.25
This case report describes Reiter's syndrome in a Black patient who had an HLA typing positive for the B27 antigen.
Positive_regulation (typing) of B27 in Reiter associated with syndrome
5) Confidence 0.49 Published 1982 Journal S. Afr. Med. J. Section Abstract Doc Link 7058466 Disease Relevance 0.45 Pain Relevance 0.09
[Occurrence of HLA B27 antigen in ankylosing spondylitis in Italy].
Positive_regulation ([Occurrence) of B27 associated with seronegative spondarthritis and spinal inflammation
6) Confidence 0.49 Published 1982 Journal Rev Rhum Mal Osteoartic Section Title Doc Link 7100804 Disease Relevance 0.83 Pain Relevance 0.46
Two had positive results for the B27 antigen, and another had positive results for the cross-reacting HLA antigen B7.
Positive_regulation (results) of B27
7) Confidence 0.49 Published 1988 Journal Am. J. Med. Section Body Doc Link 2973749 Disease Relevance 0.17 Pain Relevance 0
We determined the HLA subtypes of 267 SpA patients who were positive for the B27 antigen (as determined by serology) by using a PEL-FREEZ kit (Dynal Biotech, Wisconsin, USA).
Positive_regulation (positive) of B27
8) Confidence 0.49 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18493767 Disease Relevance 0.16 Pain Relevance 0.07
Laboratory tests were consistent with an inflammatory state and HLA typing was positive for the B27 antigen.
Positive_regulation (positive) of B27 associated with inflammation
9) Confidence 0.49 Published 2001 Journal Clin. Rheumatol. Section Abstract Doc Link 11346228 Disease Relevance 1.27 Pain Relevance 0.64
The frequency of the B27 antigen was significantly increased in the following groups: definite pelvospondylitis (26 patients and relative risk (RR) = 99), possible pelvospondylitis (20 patients, RR=4.5), definite sacroiliitis (14 patients, RR-20.1) and uroarthritis (8 patients).
Positive_regulation (frequency) of B27 associated with sacroiliitis
10) Confidence 0.49 Published 1978 Journal Scand. J. Rheumatol. Section Abstract Doc Link 725551 Disease Relevance 0.58 Pain Relevance 0.07
The results suggest a dominant heredity of AS susceptibility, and are compatible with a direct involvement of the B27 antigen in the mechanism of AS, but we cannot rule out a closely linked disease-susceptibility gene with incomplete penetrance.
Positive_regulation (involvement) of B27 associated with spinal inflammation and disease
11) Confidence 0.49 Published 1977 Journal J Rheumatol Suppl Section Abstract Doc Link 266592 Disease Relevance 1.05 Pain Relevance 0.80
Levels were higher in HLA B-27 negative patients (p = 0.02).
Positive_regulation (higher) of B-27
12) Confidence 0.49 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.53 Pain Relevance 0.28
HLA B27) could be modified by homocysteine directly or indirectly, while HLA antigens without unpaired cysteine residues (e.g.
Positive_regulation (modified) of B27 associated with seronegative spondarthritis
13) Confidence 0.45 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8766545 Disease Relevance 0.40 Pain Relevance 0.22
HLA-B5, B51, B38, B27, and B35 were significantly increased in ON patients compared with control subjects.
Positive_regulation (increased) of B27 in B35 associated with neuritis
14) Confidence 0.31 Published 2005 Journal Eur. J. Neurol. Section Abstract Doc Link 15613143 Disease Relevance 1.18 Pain Relevance 0.96
Both alleles were also distributed differently when we considered the homozygous genotypes. 3DL1/3DL1 was increased in B27-positive controls (p = 0.0008, OR = 0.33 in the Spanish population and p < 0.001, OR = 0.26 in Azoreans) compared with patients with AS.
Positive_regulation (increased) of B27 associated with spinal inflammation
15) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779409 Disease Relevance 0.40 Pain Relevance 0.40
In addition to B27, another HLA antigen may be associated with AS; the antigen Bw 16 was found to be significantly increased in B27 negative AS patients.
Positive_regulation (increased) of B27 associated with spinal inflammation
16) Confidence 0.19 Published 1977 Journal J. Immunogenet. Section Abstract Doc Link 901632 Disease Relevance 1.19 Pain Relevance 0.76
Population studies in PsA have shown increased frequency of HLA-B13, B17, B27, B38, B39, DR4 and DR7 [8,10,11].
Positive_regulation (increased) of B27 associated with arthritis
17) Confidence 0.17 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.82 Pain Relevance 0.69
Laboratory findings were pancytopenia, abnormal liver enzymes, increased ferritin levels, and positive for B27.
Positive_regulation (increased) of B27 in liver associated with pancytopenia
18) Confidence 0.16 Published 2007 Journal Clin. Rheumatol. Section Abstract Doc Link 17235650 Disease Relevance 1.86 Pain Relevance 0.56
Patients with amyloidosis secondary to rheumatoid arthritis had a high frequency of the HLA specificity B27 and of the haplotype likely to bear A2, B27.
Spec (likely) Positive_regulation (frequency) of B27 associated with amyloidosis and rheumatoid arthritis
19) Confidence 0.13 Published 1977 Journal Tissue Antigens Section Abstract Doc Link 65805 Disease Relevance 1.82 Pain Relevance 0.51
Late diastolic flow velocity was significantly increased in patients with B27-JA at the termination of exercise.
Positive_regulation (increased) of B27
20) Confidence 0.11 Published 2000 Journal Pediatr Cardiol Section Abstract Doc Link 10754085 Disease Relevance 1.15 Pain Relevance 0.28

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