INT63716

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.57
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdc) lyase activity (Hdc) cellular amino acid metabolic process (Hdc)
Anatomy Link Frequency
macrophage 2
stomach 2
brain 1
cleavage 1
Hdc (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 52 98.12 Very High Very High Very High
Inflammation 164 97.60 Very High Very High Very High
Hyperalgesia 4 95.80 Very High Very High Very High
Pain 8 82.64 Quite High
Hyperesthesia 6 71.72 Quite High
cerebral cortex 8 70.52 Quite High
Central nervous system 15 62.32 Quite High
Serotonin 4 58.92 Quite High
noradrenaline 4 57.72 Quite High
Dopamine 4 56.28 Quite High
Disease Link Frequency Relevance Heat
Stress 36 99.76 Very High Very High Very High
Crystal Associated Disease 186 99.64 Very High Very High Very High
Cerebral Malaria 98 98.00 Very High Very High Very High
INFLAMMATION 185 97.60 Very High Very High Very High
Infection 108 96.72 Very High Very High Very High
Hyperalgesia 4 95.80 Very High Very High Very High
Pain 8 82.64 Quite High
Synovitis 3 73.20 Quite High
Hyperaesthesia 6 71.72 Quite High
Anorexia 6 64.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of repeated cold stress (RCS) on both mRNA level and enzyme activity of stomach histidine decarboxylase (HDC) was studied in ddY mice.
Transcription (level) of HDC in stomach associated with stress
1) Confidence 0.69 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8750791 Disease Relevance 0.80 Pain Relevance 0.08
The effect of repeated cold stress (RCS) on both mRNA level and enzyme activity of stomach histidine decarboxylase (HDC) was studied in ddY mice.
Transcription (level) of stomach histidine decarboxylase in stomach associated with stress
2) Confidence 0.60 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8750791 Disease Relevance 0.80 Pain Relevance 0.08
Consistent with our observation that MSU crystals induced Hdc mRNA synthesis in macrophage culture, with reports of Hdc mRNA expression in neutrophils [39], and with the well documented presence of mast cells in the air pouch membrane [12], all of these three cell types are probably highly inducible sources of Hdc in the pouch membrane.
Transcription (expression) of Hdc in macrophage associated with crystal associated disease
3) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 1.15 Pain Relevance 0.45
Consistent with our observation that MSU crystals induced Hdc mRNA synthesis in macrophage culture, with reports of Hdc mRNA expression in neutrophils [39], and with the well documented presence of mast cells in the air pouch membrane [12], all of these three cell types are probably highly inducible sources of Hdc in the pouch membrane.
Transcription (synthesis) of Hdc in macrophage associated with crystal associated disease
4) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 1.21 Pain Relevance 0.46
After cessation of RCS treatment, HDC mRNA level decreased and reached the level of non-RCS treated mice, but HDC activity did not.
Transcription (level) of HDC associated with stress
5) Confidence 0.53 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8750791 Disease Relevance 0.89 Pain Relevance 0.10
TREM-1, Irg1, PROK-2, Hdc and PUMA-g mRNA levels all peaked after this dramatic burst in early cytokine transcription.
Transcription (levels) of Hdc associated with cytokine
6) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.70 Pain Relevance 0.35
These data demonstrate that RCS-treated mouse stomach induces both the de novo synthesis of the 74 kD HDC species and its proteolytic cleavage to 53 kD HDC species.
Transcription (synthesis) of HDC in cleavage associated with stress
7) Confidence 0.47 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8750791 Disease Relevance 0.82 Pain Relevance 0.08
As shown in figure 5B, the basal level of HDC mRNA was 3-fold higher in H3R?
Transcription (level) of HDC
8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696087 Disease Relevance 0.62 Pain Relevance 0
In naïve mice the biosynthetic pathway as determined by HDC mRNA expression indicates that expression in the brain was 3-fold higher in H3R?
Spec (determined) Transcription (expression) of HDC in brain
9) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696087 Disease Relevance 0.41 Pain Relevance 0.14
Effect of TRH administration into the TMN on t-MH contents, HDC activity and HDC mRNA expression in the TMN
Transcription (expression) of HDC
10) Confidence 0.37 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.12 Pain Relevance 0.03
Quantitative detection of rat HDC mRNA in the TMN by real-time reverse transcription polymerase chain reaction
Transcription (detection) of HDC
11) Confidence 0.36 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.06 Pain Relevance 0.04

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