INT63719

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Context Info
Confidence 0.52
First Reported 1995
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.91
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdc) lyase activity (Hdc) cellular amino acid metabolic process (Hdc)
Anatomy Link Frequency
macrophage 4
cleavage 2
Hdc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 104 97.92 Very High Very High Very High
Hyperalgesia 1 83.24 Quite High
Pain 4 82.96 Quite High
Hyperesthesia 4 72.04 Quite High
cytokine 30 69.64 Quite High
Central nervous system 8 62.64 Quite High
monoamine 1 33.44 Quite Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 124 99.80 Very High Very High Very High
Stress 9 99.54 Very High Very High Very High
Cerebral Malaria 49 98.00 Very High Very High Very High
INFLAMMATION 115 97.92 Very High Very High Very High
Infection 54 96.20 Very High Very High Very High
Synovitis 2 86.40 High High
Hyperalgesia 1 83.24 Quite High
Pain 4 82.96 Quite High
Hyperaesthesia 4 72.04 Quite High
Sprains And Strains 14 46.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with our observation that MSU crystals induced Hdc mRNA synthesis in macrophage culture, with reports of Hdc mRNA expression in neutrophils [39], and with the well documented presence of mast cells in the air pouch membrane [12], all of these three cell types are probably highly inducible sources of Hdc in the pouch membrane.
Positive_regulation (induced) of Transcription (synthesis) of Hdc in macrophage associated with crystal associated disease
1) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 1.21 Pain Relevance 0.46
These data demonstrate that RCS-treated mouse stomach induces both the de novo synthesis of the 74 kD HDC species and its proteolytic cleavage to 53 kD HDC species.
Positive_regulation (induces) of Transcription (synthesis) of HDC in cleavage associated with stress
2) Confidence 0.41 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8750791 Disease Relevance 0.83 Pain Relevance 0.08
As shown in figure 5B, the basal level of HDC mRNA was 3-fold higher in H3R?
Positive_regulation (higher) of Transcription (level) of HDC
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696087 Disease Relevance 0.63 Pain Relevance 0
Consistent with our observation that MSU crystals induced Hdc mRNA synthesis in macrophage culture, with reports of Hdc mRNA expression in neutrophils [39], and with the well documented presence of mast cells in the air pouch membrane [12], all of these three cell types are probably highly inducible sources of Hdc in the pouch membrane.
Spec (probably) Positive_regulation (inducible) of Transcription (expression) of Hdc in macrophage associated with crystal associated disease
4) Confidence 0.38 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 1.24 Pain Relevance 0.46

General Comments

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