INT63727

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.10
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
neurons 4
neuroblast 2
spinal cord 2
central nervous system 2
hippocampus 2
Syn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 2 99.68 Very High Very High Very High
Spinal cord 2 98.76 Very High Very High Very High
Central nervous system 2 98.64 Very High Very High Very High
Morphine 10 98.16 Very High Very High Very High
amygdala 2 96.72 Very High Very High Very High
Locus ceruleus 2 96.04 Very High Very High Very High
opiate 16 95.88 Very High Very High Very High
ischemia 7 93.48 High High
fluoxetine 4 92.28 High High
Neurotransmitter 17 90.32 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 12 99.04 Very High Very High Very High
Neurodegenerative Disease 2 98.32 Very High Very High Very High
Brain Injury 2 94.00 High High
Cv Unclassified Under Development 6 93.48 High High
Opiate Addiction 2 87.56 High High
Injury 4 75.00 Quite High
Hypoxia 2 75.00 Quite High
Brain Ischemia 1 75.00 Quite High
Fasciculation 3 72.32 Quite High
Metastasis 3 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of synapsin I mRNA in defined areas of the rat central nervous system following chronic morphine treatment.
Positive_regulation (Increased) of Gene_expression (expression) of synapsin I in central nervous system associated with central nervous system and morphine
1) Confidence 0.50 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8750825 Disease Relevance 0.09 Pain Relevance 0.99
Increased expression of synapsin I mRNA was also observed in the spinal cord of morphine-treated rats (by 3.8-fold).
Positive_regulation (Increased) of Gene_expression (expression) of synapsin I in spinal cord associated with morphine and spinal cord
2) Confidence 0.50 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.07 Pain Relevance 1.39
The neuroprotective mechanisms were associated with increased CREB phosphorylation and increased brain-derived neurotrophic factor and synapsin I mRNA expression in the hippocampus.
Positive_regulation (increased) of Gene_expression (expression) of synapsin I mRNA in hippocampus associated with hippocampus
3) Confidence 0.19 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16887358 Disease Relevance 1.08 Pain Relevance 0.76
Unlike these results, however, overexpression of Syn-1 in mature cultured hippocampal neurons was reported not to affect the number of branches [30].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Syn-1 in neurons
4) Confidence 0.16 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.33 Pain Relevance 0.08
Ectopic expression of Syn-1 in neurons was shown to increase the number of neuritic varicosities [30].
Positive_regulation (increase) of Gene_expression (expression) of Syn-1 in neurons associated with increased venous pressure under development
5) Confidence 0.12 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.10 Pain Relevance 0.08
This discrepancy may be due to the different levels of Syn-1 signaling, resulting from decreased or elevated expression of Syn-1, or reflect differences between mature hippocampal cells and neuroblast PC12 cells.
Positive_regulation (elevated) of Gene_expression (expression) of Syn-1 in neuroblast
6) Confidence 0.11 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.42 Pain Relevance 0

General Comments

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