INT63728

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Context Info
Confidence 0.72
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.38
Pain Relevance 6.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
spinal cord 1
brain 1
amygdala 1
central nervous system 1
Syn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Locus ceruleus 5 99.68 Very High Very High Very High
Nerve growth factor 17 99.08 Very High Very High Very High
Morphine 25 99.00 Very High Very High Very High
Spinal cord 5 98.76 Very High Very High Very High
amygdala 5 98.72 Very High Very High Very High
Central nervous system 5 98.64 Very High Very High Very High
opiate 40 97.32 Very High Very High Very High
tolerance 5 96.60 Very High Very High Very High
agonist 5 96.24 Very High Very High Very High
withdrawal 5 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 5 89.12 High High
Apoptosis 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Fibrosarcoma 2 5.00 Very Low Very Low Very Low
Metastasis 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here for the first time that prolonged morphine exposure causes a selective increase in the mRNA levels of synapsin I in several brain regions which are considered to be important for opiate action.
Transcription (levels) of synapsin I in brain associated with opiate and morphine
1) Confidence 0.72 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.09 Pain Relevance 1.04
These results suggest that the increases in mRNA levels of synapsin I in these specific areas can be part of the molecular mechanism(s) underlying opiate tolerance and withdrawal.
Transcription (levels) of synapsin I associated with tolerance, opiate and withdrawal
2) Confidence 0.69 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.06 Pain Relevance 1.30
Increased expression of synapsin I mRNA in defined areas of the rat central nervous system following chronic morphine treatment.
Transcription (expression) of synapsin I in central nervous system associated with central nervous system and morphine
3) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8750825 Disease Relevance 0.09 Pain Relevance 0.99
Quantitative analysis of the signals, obtained by hybridization of digoxigenin-labeled antisense RNA probe, revealed a 5.8- and 7-fold increase of synapsin I mRNA levels in the locus coeruleus and the amygdala of morphine-treated rats, respectively, as compared with control untreated rats.
Transcription (levels) of synapsin I in amygdala associated with locus ceruleus, amygdala and morphine
4) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.08 Pain Relevance 1.25
Increased expression of synapsin I mRNA was also observed in the spinal cord of morphine-treated rats (by 3.8-fold).
Transcription (expression) of synapsin I in spinal cord associated with morphine and spinal cord
5) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.07 Pain Relevance 1.39
We then measured the transcript levels of MafK, SytI, and Syn-1 using semi-quantitative PCR.
Transcription (transcript) of Syn-1
6) Confidence 0.12 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.09

General Comments

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