INT63729

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Context Info
Confidence 0.62
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.43
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
neurons 2
motor neurons 2
Syn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 5 100.00 Very High Very High Very High
addiction 1 96.04 Very High Very High Very High
opiate 8 95.64 Very High Very High Very High
Central nervous system 1 75.00 Quite High
tetrodotoxin 2 71.36 Quite High
Locus ceruleus 1 69.12 Quite High
amygdala 1 67.20 Quite High
Neurotransmitter 6 57.32 Quite High
Spinal cord 1 54.80 Quite High
anesthesia 1 52.60 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 1 96.04 Very High Very High Very High
Increased Venous Pressure Under Development 4 84.28 Quite High
Fasciculation 1 72.32 Quite High
Metastasis 1 63.44 Quite High
Cancer 2 62.80 Quite High
Injury 2 42.00 Quite Low
Death 1 39.92 Quite Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, in situ hybridization histochemistry experiments were employed to investigate the effect of chronic morphine treatment on synapsin I gene expression.
Spec (investigate) Regulation (effect) of Gene_expression (expression) of synapsin I associated with morphine
1) Confidence 0.62 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.10 Pain Relevance 0.98
We report here the effect of axotomy on the expression of glycine receptors, gephyrin, vesicular inhibitory amino acid transporter (VIAAT) and synapsin I in rat facial motor neurons as demonstrated by in situ hybridization and immunohistochemistry.
Regulation (effect) of Gene_expression (expression) of synapsin I in motor neurons
2) Confidence 0.18 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15733085 Disease Relevance 0 Pain Relevance 0.07
Unlike these results, however, overexpression of Syn-1 in mature cultured hippocampal neurons was reported not to affect the number of branches [30].
Neg (not) Regulation (affect) of Gene_expression (overexpression) of Syn-1 in neurons
3) Confidence 0.10 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.34 Pain Relevance 0.08

General Comments

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