INT63739

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 3.44
Pain Relevance 8.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
dorsal 1
spinal cord 1
striatum 1
globus pallidus 1
boutons 1
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 124 100.00 Very High Very High Very High
dopamine receptor 48 100.00 Very High Very High Very High
antagonist 43 100.00 Very High Very High Very High
Glutamate 37 100.00 Very High Very High Very High
agonist 27 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
analgesia 28 99.96 Very High Very High Very High
trigeminal ganglion 68 99.84 Very High Very High Very High
Spinal cord 22 99.58 Very High Very High Very High
fluoxetine 13 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 92 99.84 Very High Very High Very High
Generalized Anxiety Disorder 53 99.30 Very High Very High Very High
Injury 24 97.00 Very High Very High Very High
Pain 52 89.88 High High
Cytomegalovirus Infection 4 87.12 High High
Cv Unclassified Under Development 72 79.20 Quite High
Depression 1 77.32 Quite High
Manic Depressive Disorder 1 76.44 Quite High
Schizophrenia 1 75.72 Quite High
Autism 1 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic administration of the D1 dopamine receptor antagonist SCH-23390 had no significant effect on GAD67, GAD65 or preproenkephalin mRNA levels.
Neg (no) Regulation (effect) of GAD65 associated with antagonist and dopamine receptor
1) Confidence 0.58 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750862 Disease Relevance 0 Pain Relevance 0.63
Quinpirole treatment did not induce significant changes in GAD65 mRNA levels.
Neg (not) Regulation (changes) of GAD65 mRNA
2) Confidence 0.58 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750862 Disease Relevance 0 Pain Relevance 0.67
l) into the trigeminal ganglion had no effect on GAD65-mediated analgesia in the orofacial formalin test (Figure 5A).
Neg (no) Regulation (effect) of GAD65-mediated in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and analgesia
3) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.65 Pain Relevance 1.03
The effects of in vivo administration of dopamine receptor agonists or antagonists on the mRNA levels encoding for the two isoforms of glutamate decarboxylase, GAD65 and GAD67, and for preproenkephalin were studied in regions of the rat dorsal striatum by radioactive in situ hybridization histochemistry.
Regulation (effects) of GAD65 in dorsal associated with glutamate, antagonist, dopamine receptor and agonist
4) Confidence 0.43 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750862 Disease Relevance 0 Pain Relevance 0.42
In contrast, GAD65 mRNA levels remained low and were unaffected by the treatment, and EP10 was not detected.
Neg (unaffected) Regulation (unaffected) of GAD65
5) Confidence 0.42 Published 1998 Journal Perspect Dev Neurobiol Section Abstract Doc Link 9777631 Disease Relevance 0.15 Pain Relevance 0.81
Serotonergic regulation of neuropeptide and glutamic acid decarboxylase mRNA levels in the rat striatum and globus pallidus: studies with fluoxetine and DOI.
Regulation (regulation) of glutamic acid decarboxylase mRNA in striatum associated with neuropeptide and fluoxetine
6) Confidence 0.39 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9526047 Disease Relevance 0.09 Pain Relevance 0.84
The current study investigated whether chronic administration of psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid) used in the treatment of psychiatric disorders alters levels of Reelin, its receptor Vldlr, downstream molecules Gsk3 beta, Dab-1, and Gad65/67 in rat prefrontal cortex as measured by qRT-PCR and SDS-PAGE and western blotting. qRT-PCR revealed that mRNAs for Reelin, Vldlr, Dab-1, Gsk3 beta, and Gad65 were each significantly altered by at least one of the drugs tested, and in the case of Reelin, Dab-1, and Gsk3 beta, by multiple drugs.
Regulation (altered) of Gad65 in cortex associated with fluoxetine
7) Confidence 0.35 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19359144 Disease Relevance 0.38 Pain Relevance 0.23
The aim of this study was to further establish, in vivo, evidence for a link between the maturation of spinal cord innervation and the regulation of several isoforms of the synthetic enzymes of GABA, the glutamic acid decarboxylases GAD65, GAD67, and EP10, the embryonic truncated form of GAD67.
Regulation (regulation) of GAD65 in spinal cord associated with gaba and spinal cord
8) Confidence 0.31 Published 1998 Journal Perspect Dev Neurobiol Section Abstract Doc Link 9777631 Disease Relevance 0.16 Pain Relevance 0.58
However, clusters of boutons with high levels of GAD65 immunoreactivity were observed in the motor nuclei, and these were not labelled with the GLYT2 antibody.
Regulation (immunoreactivity) of GAD65 in boutons
9) Confidence 0.26 Published 2003 Journal Neuroscience Section Abstract Doc Link 12770560 Disease Relevance 0.45 Pain Relevance 0.34
Haloperidol or sulpiride did not induce significant changes in striatal GAD65 mRNA levels.
Neg (not) Regulation (changes) of GAD65 mRNA
10) Confidence 0.26 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750862 Disease Relevance 0 Pain Relevance 0.64
Quantitative densitometry was used to measure changes in mRNA levels for preproenkephalin A (ENK), D1 dopamine receptor, protachykinin (SubP), glutamic acid decarboxylase (GAD65), and D2 dopamine receptor.
Regulation (changes) of glutamic acid decarboxylase associated with dopamine receptor
11) Confidence 0.25 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630515 Disease Relevance 0 Pain Relevance 0.33
We used a recombinant adenovirus encoding the human 65 kDa isoform of GAD (GAD65) under the transcriptional control of chicken actin ubiquitous promoter (AdGAD65) as generated previously [52].
Regulation (control) of AdGAD65 associated with generalized anxiety disorder
12) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.51 Pain Relevance 0.18
The present results provide further evidence that GAD67 and GAD65 gene expression is differentially regulated in the two subpopulations of efferent striatal neurons.
Regulation (regulated) of GAD65 gene in neurons
13) Confidence 0.19 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.36
The synthesis of GABA in vertebrates including humans is regulated through the activity of L-glutamate decarboxylases 65 and 67 (GAD65 and GAD67) [18].
Regulation (regulated) of GAD65 associated with glutamate and gaba
14) Confidence 0.14 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.96 Pain Relevance 0.94
Serotonergic regulation of neuropeptide and glutamic acid decarboxylase mRNA levels in the rat striatum and globus pallidus: studies with fluoxetine and DOI.
Regulation (regulation) of glutamic acid decarboxylase mRNA in globus pallidus associated with neuropeptide and fluoxetine
15) Confidence 0.13 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9526047 Disease Relevance 0.09 Pain Relevance 0.84

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