INT63740

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Context Info
Confidence 0.66
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.78
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
striatum 3
arcuate nucleus 1
neurons 1
molar 1
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 10 100.00 Very High Very High Very High
Dopamine 37 99.66 Very High Very High Very High
agonist 20 99.54 Very High Very High Very High
dopamine receptor 39 99.38 Very High Very High Very High
antagonist 19 97.00 Very High Very High Very High
dexamethasone 5 91.16 High High
Glutamate 16 88.08 High High
GABAergic 5 86.00 High High
tetrodotoxin 3 81.68 Quite High
Intracerebroventricular 1 76.40 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 23 99.62 Very High Very High Very High
Generalized Anxiety Disorder 4 90.24 High High
Hyperinsulinism 2 73.44 Quite High
Dyskinesias 43 60.48 Quite High
Disease 41 60.16 Quite High
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Hypokinesia 2 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 2 5.00 Very Low Very Low Very Low
Dystonia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present experimental conditions, stimulation of dopamine receptors with apomorphine or SKF-38393 resulted in increased GAD65 mRNA levels whereas blockade of dopamine receptors with haloperidol or sulpiride resulted in increased GAD67 mRNA levels.
Positive_regulation (increased) of GAD65 mRNA associated with dopamine receptor
1) Confidence 0.66 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750862 Disease Relevance 0 Pain Relevance 0.52
The increases in GAD67, GAD65, and PPD mRNA levels induced by SKF-38393 were abolished by the administration of the D1 receptor antagonist SCH-23390.
Positive_regulation (increases) of GAD65 associated with antagonist
2) Confidence 0.65 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.36
Quantitative analysis at the cellular level indicated that GAD67 mRNA levels were increased in PPE-labeled neurons, whereas GAD65 mRNA levels were increased in PPE-unlabeled neurons.
Positive_regulation (increased) of GAD65 in neurons
3) Confidence 0.65 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.28
Chronic and systemic injections of apomorphine or SKF-38393 induced further increases in striatal GAD65 and GAD67 mRNA levels.
Positive_regulation (increases) of GAD65
4) Confidence 0.65 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.32
In adult rats depleted of dopamine as neonates, an increase of GAD65 and GAD67 mRNA levels was measured in the striatum.
Positive_regulation (increase) of GAD65 in striatum associated with dopamine
5) Confidence 0.65 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.27
Chronic administration of the dopamine receptor agonist apomorphine or the D1 dopamine receptor agonist SKF-38393 resulted in increased GAD65 mRNA levels in the dorsomedial, ventromedial, dorsolateral and ventrolateral sectors of the striatum.
Positive_regulation (increased) of GAD65 mRNA in striatum associated with dopamine receptor and agonist
6) Confidence 0.48 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750862 Disease Relevance 0 Pain Relevance 0.57
Haloperidol or sulpiride did not induce significant changes in striatal GAD65 mRNA levels.
Neg (not) Positive_regulation (induce) of GAD65 mRNA
7) Confidence 0.48 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750862 Disease Relevance 0 Pain Relevance 0.64
The increases in GAD67, GAD65, and PPD mRNA levels induced by SKF-38393 were abolished by the administration of the D1 receptor antagonist SCH-23390.
Positive_regulation (increases) of GAD65 associated with antagonist
8) Confidence 0.47 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.36
In MPTP-treated primates, GAD65 mRNA and GAD67 mRNA are increased in the striatum (Pedneault and Soghomonian, 1994; Soghomonian et al., 1994; Levy et al., 1995).
Positive_regulation (increased) of GAD65 in striatum associated with parkinson's disease
9) Confidence 0.40 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.71 Pain Relevance 0.07
Low molar Gck abundance fits with the low levels of its mRNA (3, 8 and 240 times lower than that of respectively Gad2, Hadh and Slc2a2/Glut2, our unpublished data).
Positive_regulation (respectively) of Gad2 in molar
10) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997773 Disease Relevance 0 Pain Relevance 0
Furthermore, increases in the GABA-synthesizing enzyme glutamic acid decarboxylase 65 (GAD65) mRNA expression preceded decreases in NPY mRNA expression in the arcuate nucleus in the cultures.
Positive_regulation (increases) of GABA-synthesizing enzyme glutamic acid decarboxylase 65 in arcuate nucleus associated with gaba
11) Confidence 0.16 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.07 Pain Relevance 0.93

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