INT63763

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2003
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.65
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou2f2) DNA binding (Pou2f2) cytoplasm (Pou2f2)
Anatomy Link Frequency
neuronal 1
sciatic nerve 1
neurons 1
dorsal root ganglion 1
Pou2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 9 98.96 Very High Very High Very High
Nerve growth factor 19 98.88 Very High Very High Very High
qutenza 6 96.60 Very High Very High Very High
Neuropeptide 10 95.40 Very High Very High Very High
substance P 2 94.80 High High
Calcitonin gene-related peptide 2 94.28 High High
dorsal root ganglion 2 89.88 High High
Inflammatory response 2 88.08 High High
Peripheral nerve injury 9 50.00 Quite Low
Central nervous system 48 7.88 Low Low
Disease Link Frequency Relevance Heat
Injury 27 96.40 Very High Very High Very High
Ganglion Cysts 2 89.40 High High
INFLAMMATION 5 88.08 High High
Targeted Disruption 2 87.76 High High
Nervous System Injury 12 50.00 Quite Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to define a possible role for Oct-2 in neurotrophin signalling, we examined the expression of an NGF-regulated channel (capsaicin-evoked ion fluxes), neuropeptides (substance P, calcitonin gene-related peptide), structural proteins (neurofilaments and peripherin) and receptors (trks) in dorsal root ganglion neurones derived from perinatal transgenic mice containing a defective Oct-2 structural gene.
Spec (possible) Positive_regulation (role) of Oct-2 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, qutenza, calcitonin gene-related peptide, targeted disruption, nerve growth factor, neuropeptide and substance p
1) Confidence 0.50 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750882 Disease Relevance 0.18 Pain Relevance 0.47
The number of sensory neurones and the gross morphology of CNS tissues that normally express high levels of Oct-2 were also examined and found to be normal in the null mutant.
Positive_regulation (levels) of Oct-2
2) Confidence 0.46 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750882 Disease Relevance 0.24 Pain Relevance 0.57
The transcription factor Oct-2 is belonging to the POU family and is induced in sensory neurons after sciatic nerve transection [42].
Positive_regulation (induced) of Oct-2 in sciatic nerve associated with sciatic nerve
3) Confidence 0.15 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0.07 Pain Relevance 0.28
In our investigations, c-maf and Oct-2 are induced in axotomized facial nucleus neurons.
Positive_regulation (induced) of Oct-2 in neurons
4) Confidence 0.15 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0.06 Pain Relevance 0.26
This up-regulation of Oct-2 has been suggested to induce the phenotypic changes involved in the neuronal response to injury [42].
Positive_regulation (regulation) of Oct-2 in neuronal associated with injury
5) Confidence 0.10 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0.10 Pain Relevance 0.25

General Comments

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