INT63769
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
NGF protein content of the bladder was unaffected by ovariectomy or hormone treatment, and bladder NGF mRNA was unaffected by ovariectomy or hormone treatment. | |||||||||||||||
| |||||||||||||||
|
NGF protein content of the bladder was unaffected by ovariectomy or hormone treatment, and bladder NGF mRNA was unaffected by ovariectomy or hormone treatment. | |||||||||||||||
| |||||||||||||||
|
Collectively, these results indicate that reproductive hormones have the capacity to regulate NGF message and protein in a manner that varies among organs. | |||||||||||||||
| |||||||||||||||
|
NGF protein content of the hearts of ovariectomized mice treated with estrogen alone or in conjunction with progesterone was increased relative to intact controls and ovariectomized, untreated mice, but neither ovariectomy or hormone replacement affected NGF mRNA content in the heart. | |||||||||||||||
| |||||||||||||||
|
We found that treatment of mice with the estrogen antagonist ICI 182,780 had no effect on bladder NGF content but decreased bladder NGF messenger RNA. | |||||||||||||||
| |||||||||||||||
|
Current and future therapies include external beam radiation, osteoclast-targeted inhibiting agents, anti-inflammatory drugs, transient receptor potential vanilloid type 1 antagonists, and antibody therapies that target nerve growth factor or tumor angiogenesis. | |||||||||||||||
| |||||||||||||||
|
NGF mRNA levels are not altered in AD. | |||||||||||||||
| |||||||||||||||
|
Injection of thymulin only did not alter the nociceptive thresholds or the levels of IL-1beta and NGF. | |||||||||||||||
| |||||||||||||||
|
The role of inflammatory mediators such as NGF in regulating nociceptor function has been clarified in mis-expression and deletion studies. | |||||||||||||||
| |||||||||||||||
|
The broad scope of neurotrophin action is well documented in the case of nerve growth factor (NGF) and its effect on nociceptors and nociception. | |||||||||||||||
| |||||||||||||||
|
Ovariectomy did not affect NGF protein concentrations in the salivary gland, but treatment of ovariectomized mice with estrogen alone or in conjunction with progesterone stimulated concentrations of NGF protein that exceeded those observed in intact control or ovariectomized, untreated mice. | |||||||||||||||
| |||||||||||||||
|
OBJECTIVE: To investigate the effects of the intravesical instillation of Escherichia coli lipopolysaccharide (LPS) on nerve growth factor (NGF, which may mediate the pain associated with inflammation) protein and mRNA in the bladders of mice. | |||||||||||||||
| |||||||||||||||
|
OBJECTIVE: To investigate the effects of the intravesical instillation of Escherichia coli lipopolysaccharide (LPS) on nerve growth factor (NGF, which may mediate the pain associated with inflammation) protein and mRNA in the bladders of mice. | |||||||||||||||
| |||||||||||||||
|
In order to differentiate between the effects of NGF administration on c-fos expression and the effects of surgical preparation, needle insertion and intramuscular injection, the experiments were conducted in three groups. | |||||||||||||||
| |||||||||||||||
|
The change in NGF levels after capsaicin provocation differed significantly between the two groups (p < 0.005; Figure 1). | |||||||||||||||
| |||||||||||||||
|
Since only a subset of sensory neurons in the NGF-transgenic mice received the sympathetic projections, we hypothesized that sympathetic sprouting was targeted to those neurons affected by increased levels of NGF. | |||||||||||||||
| |||||||||||||||
|
It has been shown that IB(4)-positive neurons depend on glial-derived neurotrophic factor (GDNF), whereas IB(4)-negative neurons depend on NGF for survival during postnatal development (Molliver et al., 1997). | |||||||||||||||
| |||||||||||||||
|
In the adult, neurotrophins appear to be expressed in most tissues at very low levels, whereas the levels of NGF (and in some tissues BDNF and NT-3) are dramatically up-regulated by inflammation and/or injury [14,16]. | |||||||||||||||
| |||||||||||||||
|
Their generation seems independent of ret and NGF signalling. | |||||||||||||||
| |||||||||||||||
|
Preceding TTX administration prevented ATP-induced facilitation, but was without effect on NGF. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.