INT63769

Context Info Confidence 0.62 First Reported 1995 Last Reported 2010 Negated 9 Speculated 3 Reported most in Abstract Documents 44 Total Number 49 Disease Relevance 21.82 Pain Relevance 25.84

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)

Anatomy Link Frequency nerve 14 bladder 4 neurons 4 salivary gland 2 nociceptor 2 Ngf (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 709 100.00 qutenza 231 100.00 Pain 177 100.00 Inflammation 110 100.00 cytokine 48 100.00 Hyperalgesia 28 100.00 Inflammatory mediators 13 100.00 chemokine 9 100.00 addiction 3 100.00 nociceptor 72 99.84

Disease Link Frequency Relevance Heat Pain 177 100.00 INFLAMMATION 135 100.00 Nociception 47 100.00 Hyperalgesia 40 100.00 Myocardial Infarction 5 99.88 Disease 391 99.84 Cancer 178 99.84 Ganglion Cysts 215 99.58 Granuloma 3 99.30 Diabetic Neuropathy 39 99.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NGF protein content of the bladder was unaffected by ovariectomy or hormone treatment, and bladder NGF mRNA was unaffected by ovariectomy or hormone treatment.

Neg (unaffected) Regulation (unaffected) of NGF in bladder associated with nerve growth factor

1) Confidence 0.62 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.08 Pain Relevance 0.65

NGF protein content of the bladder was unaffected by ovariectomy or hormone treatment, and bladder NGF mRNA was unaffected by ovariectomy or hormone treatment.

Neg (unaffected) Regulation (unaffected) of NGF protein in bladder associated with nerve growth factor

2) Confidence 0.62 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.08 Pain Relevance 0.66

Collectively, these results indicate that reproductive hormones have the capacity to regulate NGF message and protein in a manner that varies among organs.

Regulation (regulate) of NGF associated with nerve growth factor

3) Confidence 0.62 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.07 Pain Relevance 0.62

NGF protein content of the hearts of ovariectomized mice treated with estrogen alone or in conjunction with progesterone was increased relative to intact controls and ovariectomized, untreated mice, but neither ovariectomy or hormone replacement affected NGF mRNA content in the heart.

Neg (neither) Regulation (affected) of NGF in hearts associated with nerve growth factor

4) Confidence 0.62 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.09 Pain Relevance 0.65

We found that treatment of mice with the estrogen antagonist ICI 182,780 had no effect on bladder NGF content but decreased bladder NGF messenger RNA.

Neg (no) Regulation (effect) of NGF in bladder associated with nerve growth factor and antagonist

5) Confidence 0.62 Published 2001 Journal Urology Section Abstract Doc Link 11378049 Disease Relevance 0.60 Pain Relevance 0.91

Current and future therapies include external beam radiation, osteoclast-targeted inhibiting agents, anti-inflammatory drugs, transient receptor potential vanilloid type 1 antagonists, and antibody therapies that target nerve growth factor or tumor angiogenesis.

Regulation (target) of nerve growth factor in external associated with inflammation, nerve growth factor, cancer, antagonist and cinod

6) Confidence 0.60 Published 2006 Journal Clin. Cancer Res. Section Abstract Doc Link 17062706 Disease Relevance 1.35 Pain Relevance 0.61

NGF mRNA levels are not altered in AD.

Neg (not) Regulation (altered) of NGF associated with nerve growth factor and disease

7) Confidence 0.52 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.81 Pain Relevance 0.42

Injection of thymulin only did not alter the nociceptive thresholds or the levels of IL-1beta and NGF.

Neg (not) Regulation (alter) of NGF associated with nociception and nerve growth factor

8) Confidence 0.45 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.89 Pain Relevance 0.79

The role of inflammatory mediators such as NGF in regulating nociceptor function has been clarified in mis-expression and deletion studies.

Regulation (role) of NGF in nociceptor associated with inflammatory mediators and nociceptor

9) Confidence 0.45 Published 1996 Journal Trends Neurosci. Section Abstract Doc Link 8761960 Disease Relevance 0.26 Pain Relevance 0.71

The broad scope of neurotrophin action is well documented in the case of nerve growth factor (NGF) and its effect on nociceptors and nociception.

Regulation (effect) of NGF in nociceptors associated with nociception, nerve growth factor and nociceptor

10) Confidence 0.45 Published 1999 Journal Microsc. Res. Tech. Section Abstract Doc Link 10383118 Disease Relevance 0.31 Pain Relevance 0.75

Ovariectomy did not affect NGF protein concentrations in the salivary gland, but treatment of ovariectomized mice with estrogen alone or in conjunction with progesterone stimulated concentrations of NGF protein that exceeded those observed in intact control or ovariectomized, untreated mice.

Neg (not) Regulation (affect) of NGF protein in salivary gland associated with nerve growth factor

11) Confidence 0.45 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.14 Pain Relevance 0.52

OBJECTIVE: To investigate the effects of the intravesical instillation of Escherichia coli lipopolysaccharide (LPS) on nerve growth factor (NGF, which may mediate the pain associated with inflammation) protein and mRNA in the bladders of mice.

Spec (investigate) Regulation (effects) of nerve growth factor in nerve associated with pain, inflammation and nerve growth factor

12) Confidence 0.45 Published 2001 Journal BJU Int. Section Abstract Doc Link 11350415 Disease Relevance 0.20 Pain Relevance 0.24

OBJECTIVE: To investigate the effects of the intravesical instillation of Escherichia coli lipopolysaccharide (LPS) on nerve growth factor (NGF, which may mediate the pain associated with inflammation) protein and mRNA in the bladders of mice.

Spec (investigate) Regulation (effects) of NGF in nerve associated with pain, inflammation and nerve growth factor

13) Confidence 0.45 Published 2001 Journal BJU Int. Section Abstract Doc Link 11350415 Disease Relevance 0.20 Pain Relevance 0.24

In order to differentiate between the effects of NGF administration on c-fos expression and the effects of surgical preparation, needle insertion and intramuscular injection, the experiments were conducted in three groups.

Regulation (effects) of NGF associated with nerve growth factor

14) Confidence 0.45 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16426266 Disease Relevance 0.29 Pain Relevance 0.48

The change in NGF levels after capsaicin provocation differed significantly between the two groups (p < 0.005; Figure 1).

Regulation (change) of NGF associated with qutenza and nerve growth factor

15) Confidence 0.45 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.08 Pain Relevance 0.93

Since only a subset of sensory neurons in the NGF-transgenic mice received the sympathetic projections, we hypothesized that sympathetic sprouting was targeted to those neurons affected by increased levels of NGF.

Regulation (affected) of NGF in sympathetic associated with targeted disruption

16) Confidence 0.45 Published 1998 Journal Neuroreport Section Abstract Doc Link 9601676 Disease Relevance 0.36 Pain Relevance 0.09

It has been shown that IB(4)-positive neurons depend on glial-derived neurotrophic factor (GDNF), whereas IB(4)-negative neurons depend on NGF for survival during postnatal development (Molliver et al., 1997).

Regulation (depend) of NGF in neurons

17) Confidence 0.41 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10414978 Disease Relevance 0.13 Pain Relevance 0.43

In the adult, neurotrophins appear to be expressed in most tissues at very low levels, whereas the levels of NGF (and in some tissues BDNF and NT-3) are dramatically up-regulated by inflammation and/or injury [14,16].

Regulation (regulated) of NGF associated with inflammation, nerve growth factor and injury

18) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.64 Pain Relevance 0.94

Their generation seems independent of ret and NGF signalling.

Neg (independent) Spec (seems) Regulation (independent) of NGF associated with nerve growth factor

19) Confidence 0.33 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34

Preceding TTX administration prevented ATP-induced facilitation, but was without effect on NGF.

Neg (without) Regulation (effect) of NGF associated with tetrodotoxin and nerve growth factor

20) Confidence 0.27 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17850351 Disease Relevance 0.31 Pain Relevance 1.11

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