INT63773

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2011
Negated 0
Speculated 4
Reported most in Body
Documents 25
Total Number 29
Disease Relevance 10.41
Pain Relevance 10.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (DRD2) plasma membrane (DRD2) signal transducer activity (DRD2)
Anatomy Link Frequency
striatum 6
neurons 3
brain 2
Calu-6 1
caudate nucleus 1
DRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 628 100.00 Very High Very High Very High
dopamine receptor 159 100.00 Very High Very High Very High
Enkephalin 43 100.00 Very High Very High Very High
Catechol-O-methyltransferase 34 99.84 Very High Very High Very High
Serotonin 53 99.74 Very High Very High Very High
Neuropeptide 4 99.64 Very High Very High Very High
Potency 3 99.48 Very High Very High Very High
substance P 3 98.48 Very High Very High Very High
positron emission tomography 146 97.52 Very High Very High Very High
drug abuse 45 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 12 99.76 Very High Very High Very High
Diabetes Mellitus 5 99.56 Very High Very High Very High
Lung Cancer 1 99.50 Very High Very High Very High
Disease 301 99.30 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1215 99.24 Very High Very High Very High
Acth-secreting Pituitary Adenoma 7 99.00 Very High Very High Very High
Chronic Fatigue Syndrome 14 98.36 Very High Very High Very High
Liver Disease 36 98.02 Very High Very High Very High
Myocardial Infarction 2 97.88 Very High Very High Very High
Substance Abuse 57 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D2 dopamine receptor (D2R) gene expression was analyzed by in situ hybridization and D2R ligand autoradiography in the human striatum during ontogeny.
Spec (analyzed) Gene_expression (expression) of D2R in striatum associated with dopamine receptor
1) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332736 Disease Relevance 0 Pain Relevance 0.43
D2R mRNA and ([3H]YM-09151-2)-binding sites were detected in the striatum from week 12 of fetal life.
Gene_expression (detected) of D2R mRNA in striatum associated with dopamine receptor
2) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332736 Disease Relevance 0 Pain Relevance 0.60
These results demonstrate that functional D2R are expressed as early as week 12 in the striatum with a heterogeneous distribution.
Gene_expression (expressed) of D2R in striatum associated with dopamine receptor
3) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332736 Disease Relevance 0 Pain Relevance 0.97
Before birth, the neurons expressing enkephalin and D1R mRNAs were preferentially distributed in the matrix and in the striosomes, respectively, while the neurons expressing D2R mRNA did not display a preferential localization.
Gene_expression (expressing) of D2R mRNA in neurons associated with dopamine receptor and enkephalin
4) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332736 Disease Relevance 0 Pain Relevance 1.12
Ontogeny of the striatal neurons expressing the D2 dopamine receptor in humans: an in situ hybridization and receptor-binding study.
Gene_expression (expressing) of D2 dopamine receptor in neurons associated with dopamine receptor and enkephalin
5) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9332736 Disease Relevance 0 Pain Relevance 0.94
D2 dopamine receptor (D2R) gene expression was analyzed by in situ hybridization and D2R ligand autoradiography in the human striatum during ontogeny.
Spec (analyzed) Gene_expression (expression) of D2 dopamine receptor in striatum associated with dopamine receptor
6) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332736 Disease Relevance 0 Pain Relevance 0.43
Neurochemical studies of the brains of patients with liver disease have confirmed for the most part the results from neuroimaging studies: a significant decrease in D2R levels in the basal ganglia and no observed decrease in dopamine levels (Table 1).
Gene_expression (levels) of D2R in brains associated with liver disease and dopamine
7) Confidence 0.70 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.35 Pain Relevance 0.23
Our findings also demonstrate that, in contrast to what was expected from similar studies in rodents, D2R mRNA and enkephalin mRNA do not display identical, overlapping expression patterns in striatal neurons during human ontogeny.
Gene_expression (expression) of D2R mRNA in neurons associated with dopamine receptor and enkephalin
8) Confidence 0.67 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332736 Disease Relevance 0 Pain Relevance 0.86
There was no support for a main effect of DRD2 or COMT in either sample, irrespective of whether individuals were characterised by genotype or presence of the A1 or Val allele, on HA or NS scores.
Gene_expression (effect) of DRD2 associated with catechol-o-methyltransferase
9) Confidence 0.67 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.23
Thus, particularly steep delay discounting (increased impulsivity) in those with both long DRD4 and A1 DRD2 alleles may reflect the concurrent variation in two key points in the reward decision-making loops spanning the corticostriatal-mesolimbic axis.
Gene_expression (alleles) of DRD2 associated with attention deficit hyperactivity disorder
10) Confidence 0.65 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.18 Pain Relevance 0.07
Repeating the principal analyses in the largest single racial group, those with European ancestry, the main effect of DRD2 on DDT k values was marginally significant (F (1,74) = 3.487, p = .066, ?
Gene_expression (effect) of DRD2
11) Confidence 0.65 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.07 Pain Relevance 0
p2 = .047), as was the interaction effect of DRD2 and DRD4 on DDT k (F (1,74) = 2.729, p = .103, ?
Gene_expression (effect) of DRD2
12) Confidence 0.65 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.12 Pain Relevance 0
Anti-OPRM1 antibodies, anti-HTR1A antibodies, and anti-DRD2 antibodies were found in 15.2, 1.7, and 5.0% of patients with CFS, respectively.
Gene_expression (found) of DRD2 associated with chronic fatigue syndrome
13) Confidence 0.63 Published 2003 Journal Int. J. Mol. Med. Section Abstract Doc Link 12851722 Disease Relevance 1.27 Pain Relevance 0.22
In a preliminary report in which four Mn-exposed animal were used, they found no significant effect of Mn exposure (mean cumulative Mn dose, 165.5 mg Mn/kg body weight; range, 152–174 mg Mn/kg body weight) on DAT or D2R receptor levels using autoradiography or tyrosine hydroxylase immunohistochemistry, or on the concentration of dopamine and its metabolite homovanillic acid (HVA) measured by HPLC with electrochemical detection in the caudate or putamen, relative to naive controls (Guilarte et al. 2006a).
Gene_expression (levels) of D2R receptor in putamen associated with dopamine and body weight
14) Confidence 0.61 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.20 Pain Relevance 0.28
In this regard, Lee et al. [46] found an association between novelty seeking (NS) and both the dopamine D4 receptor gene (DRD4) long alleles and the Taq1 A1 and Taq1 B1 sites of the dopamine D2 receptor gene.
Gene_expression (seeking) of dopamine D2 receptor associated with dopamine
15) Confidence 0.59 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 0.63 Pain Relevance 0.38
DRD2 Dopamine D2 receptor gene
Gene_expression (gene) of DRD2 associated with dopamine
16) Confidence 0.59 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 1.80 Pain Relevance 0.48
It is not in any known regulatory region, and although the A1 allele is associated with a decrease in dopamine D2 binding and glucose metabolic rates in many brain regions [83,89,90], its mechanism for influencing DRD2 expression is unknown.
Gene_expression (expression) of DRD2 in brain associated with dopamine
17) Confidence 0.58 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.43 Pain Relevance 0.34
Importantly, PD patients have normal or increased levels of D2R in the striatum (Table 2).
Gene_expression (levels) of D2R in striatum associated with disease
18) Confidence 0.55 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.74 Pain Relevance 0.47
The cellular expression of the mRNAs encoding the dopamine D1 receptor, dopamine D2 receptor and the neuropeptides enkephalin and substance P was determined in fresh frozen sections of human post-mortem caudate nucleus from control and schizophrenic brains using the technique of radioactive in situ hybridisation coupled with computer-assisted image analysis.
Spec (determined) Gene_expression (expression) of dopamine D2 receptor in caudate nucleus associated with dopamine, neuropeptide, enkephalin, schizophrenia and substance p
19) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750894 Disease Relevance 0.22 Pain Relevance 0.37
DRD2 Dopamine D2 receptor gene
Gene_expression (gene) of Dopamine D2 receptor associated with dopamine
20) Confidence 0.51 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 1.80 Pain Relevance 0.48

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