INT63774

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Context Info
Confidence 0.53
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 1.48
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (DRD1) plasma membrane (DRD1) nucleus (DRD1)
signal transducer activity (DRD1)
Anatomy Link Frequency
caudate nucleus 2
pyramidal neurons 1
synapses 1
neural 1
interneurons 1
DRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 408 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
GABAergic 10 99.84 Very High Very High Very High
Neuropeptide 4 98.76 Very High Very High Very High
Pyramidal cell 60 98.68 Very High Very High Very High
dopamine receptor 5 96.80 Very High Very High Very High
Catechol-O-methyltransferase 85 93.56 High High
interneuron 5 73.84 Quite High
gABA 5 43.20 Quite Low
Disease Link Frequency Relevance Heat
Schizophrenia 20 99.80 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 180 97.76 Very High Very High Very High
Cognitive Disorder 85 91.92 High High
Stress 20 5.00 Very Low Very Low Very Low
Sleep Disorders 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 10 5.00 Very Low Very Low Very Low
Hyperkinesis 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 5 5.00 Very Low Very Low Very Low
Hypotension 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dopamine D1 receptor, D2 receptor, proenkephalin A and substance P gene expression in the caudate nucleus of control and schizophrenic tissue: a quantitative cellular in situ hybridisation study.
Gene_expression (expression) of Dopamine D1 receptor in caudate nucleus associated with dopamine, schizophrenia and substance p
1) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8750894 Disease Relevance 0.31 Pain Relevance 0.63
The cellular expression of the mRNAs encoding the dopamine D1 receptor, dopamine D2 receptor and the neuropeptides enkephalin and substance P was determined in fresh frozen sections of human post-mortem caudate nucleus from control and schizophrenic brains using the technique of radioactive in situ hybridisation coupled with computer-assisted image analysis.
Gene_expression (expression) of dopamine D1 receptor in caudate nucleus associated with dopamine, neuropeptide, enkephalin, schizophrenia and substance p
2) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750894 Disease Relevance 0.22 Pain Relevance 0.37
The D1 receptor was also found to be in close proximity to putative glutamatergic axon terminals, giving rise asymmetric synapses on the same spine.
Gene_expression (found) of D1 receptor in synapses
3) Confidence 0.45 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.15 Pain Relevance 0.24
Muly et al. also studied the distribution of D1 receptor in GABAergic interneurons, and shown it is preferentially found in those subtypes of interneurons which provide the strongest inhibitory input to the perisomatic region of cortical pyramidal cells [23].
Gene_expression (distribution) of D1 receptor in interneurons associated with pyramidal cell and gabaergic
4) Confidence 0.45 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.16 Pain Relevance 0.31
This leads to an increase in D2 and a decrease in D1 receptor transmission; as a result there is decreased stability of neural networks, underlying working memory representations.
Gene_expression (transmission) of D1 receptor in neural
5) Confidence 0.45 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.16 Pain Relevance 0.63
On pyramidal neurons, the spine may act as a diffusion barrier, while on interneurons D1 receptor synapses are located on the shaft allowing for more diffusion of second messengers [24,25].


Gene_expression (synapses) of D1 receptor in pyramidal neurons associated with pyramidal cell
6) Confidence 0.45 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.14 Pain Relevance 0.53
While an association has been proposed between DRD1 and schizophrenia, most genetic association studies in ADHD have been directed towards the dopamine transporter, DAT1 and the DRD4 receptor.
Gene_expression (proposed) of DRD1 associated with dopamine, attention deficit hyperactivity disorder and schizophrenia
7) Confidence 0.45 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.34 Pain Relevance 0.48

General Comments

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