INT63816

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Context Info
Confidence 0.23
First Reported 1995
Last Reported 2011
Negated 0
Speculated 4
Reported most in Body
Documents 20
Total Number 26
Disease Relevance 22.28
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sciatic nerve 1
upper 1
T-cells 1
Aia1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 819 100.00 Very High Very High Very High
aspirin 615 99.66 Very High Very High Very High
Sciatic nerve 1 99.48 Very High Very High Very High
addiction 3 99.44 Very High Very High Very High
Lasting pain 2 98.72 Very High Very High Very High
withdrawal 1 96.86 Very High Very High Very High
Hyperalgesia 2 96.24 Very High Very High Very High
rheumatoid arthritis 111 92.68 High High
tail-flick 2 91.28 High High
agonist 3 86.72 High High
Disease Link Frequency Relevance Heat
Asthma 1306 100.00 Very High Very High Very High
Arthritis 858 100.00 Very High Very High Very High
Osteophyte 12 100.00 Very High Very High Very High
Disease 222 99.92 Very High Very High Very High
Pain 21 98.72 Very High Very High Very High
Obesity 68 97.24 Very High Very High Very High
Ankylosis 6 96.24 Very High Very High Very High
Hyperalgesia 3 96.24 Very High Very High Very High
Nicotine Addiction 58 96.12 Very High Very High Very High
Hypersensitivity 88 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aspirin-induced asthma (AIA) should be recognized as an important types of bronchial asthma for the following reasons. 1) The pathogenesis of AIA is specific.
AIA Binding (recognized) of associated with asthma and aspirin
1) Confidence 0.23 Published 1995 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 8752493 Disease Relevance 1.21 Pain Relevance 0.17
This dependence is shown by the ability to pass rat AIA [11, 108, 109] as well as rat [110] and mouse [111] CIA to nonimmunized (naive) recipients by transferring sensitized T-cells from affected donors and by the inability to induce AIA [27] or SCW [112] in athymic rats.
AIA Binding (pass) of in T-cells associated with addiction and arthritis
2) Confidence 0.06 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 1.44 Pain Relevance 0.65
This period is usually one week after the onset of clinical disease in our AIA, CIA, and SCW models.


AIA Binding (our) of associated with disease and arthritis
3) Confidence 0.06 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 1.04 Pain Relevance 0.43
The widespread formation of osteophytes along the periosteal surface in some RMIA (AIA > CIA ?
AIA Binding (formation) of associated with osteophyte and arthritis
4) Confidence 0.06 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 1.97 Pain Relevance 0.57
By examining the allelic associations of single nucleotide polymorphisms (SNPs) of AIA candidate genes relevant to an immune response with AIA, two SNPs, one each of INDO and IL1R2, showed significant associations with AIA (P=0.011 and 0.026 after Bonferroni's correction, respectively, in AIA vs.
AIA Binding (associations) of
5) Confidence 0.05 Published 2009 Journal Clin. Exp. Allergy Section Body Doc Link 19489917 Disease Relevance 0 Pain Relevance 0
In AIA-ATA association analysis, modest associations of the two SNPs with AIA were observed.
AIA Binding (associations) of
6) Confidence 0.05 Published 2009 Journal Clin. Exp. Allergy Section Body Doc Link 19489917 Disease Relevance 0 Pain Relevance 0
Logistic analyses were used to evaluate the associations of CACNG6 polymorphisms with AIA.
AIA Binding (associations) of
7) Confidence 0.04 Published 2010 Journal BMC Med. Genet. Section Body Doc Link 20860846 Disease Relevance 0 Pain Relevance 0
METHODS: To study the associations between AIA and polymorphisms in CACNG6 gene, eight variants were genotyped in 102 AIA cases and 429 aspirin-tolerant asthma (ATA) controls.
AIA Binding (associations) of
8) Confidence 0.04 Published 2010 Journal BMC Med. Genet. Section Body Doc Link 20860846 Disease Relevance 0 Pain Relevance 0
Several SNPs in the promoter of LTC4S [19], [45] and ALOX5 [20] that encode key enzymes for CysLT synthesis also showed significant associations with AIA [13], [46].
AIA Binding (associations) of associated with asthma
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 1.30 Pain Relevance 0.15
In one study, 370 SNPs of 63 candidate genes that are involved in the arachidonic acid metabolic cascade were studied for associations with AIA.
AIA Binding (associations) of associated with asthma
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 1.15 Pain Relevance 0.17
In the present study, logistic and regression analyses yielded significant associations between variations of the CEP68 gene and AIA, with the lowest P value at the nonsynonymous SNP rs7572857.
AIA Binding (associations) of associated with asthma
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.66 Pain Relevance 0.08
Other previous reports have suggested associations between genetic polymorphisms and AIA.
AIA Binding (associations) of associated with asthma
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.99 Pain Relevance 0.12
This study also observed modest associations of other genes with AIA.
AIA Binding (associations) of associated with asthma
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.89 Pain Relevance 0.06
Mechanical hyperalgesia was measured as paw withdrawal threshold (PWT) in response to a mechanical stimulus in two animal models of persistent pain; (1) 24 h following subplantar injections of Freund's complete adjuvant (FCA) into the left hind paw or (2) 11-15 days following a partial ligation of the left sciatic nerve.
adjuvant Spec (partial) Binding (ligation) of in sciatic nerve associated with pain, hyperalgesia, lasting pain, sciatic nerve and withdrawal
14) Confidence 0.01 Published 2000 Journal Pain Section Abstract Doc Link 10779668 Disease Relevance 0.72 Pain Relevance 0.80
For examination of AIA risk association, we genotyped 8 common SNPs in the CACNG6 gene.
AIA Spec (examination) Binding (association) of associated with asthma
15) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954844 Disease Relevance 0.82 Pain Relevance 0.07
Among the haplotypes, CACNG6_BL1_ht6, the only one containing the rare T variant of rs192808, also showed significant association with risk of AIA (P = 0.003, Pcorr = 0.02 in co-dominant model; P = 0.001, Pcorr = 0.0087 in dominant model), showing a similar pattern with the association of rs192808 SNP (Table 2).
AIA Binding (association) of associated with asthma
16) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954844 Disease Relevance 0.89 Pain Relevance 0.03
Logistic analysis was used to analyze whether the genetic polymorphisms were associated with AIA.
AIA Spec (whether) Binding (associated) of associated with asthma
17) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954844 Disease Relevance 1.40 Pain Relevance 0
Initially, 18 SNPs and 4 haplotypes showed associations with AIA.
AIA Binding (associations) of associated with asthma
18) Confidence 0.01 Published 2010 Journal BMC Pulm Med Section Abstract Doc Link PMC2896935 Disease Relevance 1.88 Pain Relevance 0.34
As shown in Figure 2, there were 18 SNPs out of 66 that showed initial significant association with AIA. 12 SNPs out of the 18 showed association with the susceptibility to the risk of AIA, furthermore, rs7179742 had significantly higher MAF for AIA than that of ATA, showing increased susceptibility of AIA (MAF = 0.358 and 0.262, respectively).
AIA Binding (association) of associated with asthma
19) Confidence 0.01 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2896935 Disease Relevance 0.71 Pain Relevance 0.04
The genotype and haplotype association with AIA were analyzed using logistic models with age (continuous value), gender (male = 0, female = 1), smoking status (non-smoker = 0, ex-smoker = 1, smoker = 2), atopy (absence = 0, presence = 1), and BMI as covariates.
AIA Binding (association) of associated with asthma, nicotine addiction and obesity
20) Confidence 0.01 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2896935 Disease Relevance 0.49 Pain Relevance 0.03

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