INT6382

Context Info Confidence 0.61 First Reported 1983 Last Reported 2010 Negated 4 Speculated 8 Reported most in Abstract Documents 36 Total Number 44 Disease Relevance 7.00 Pain Relevance 26.48

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency brain 12 neural 4 NG108-15 2 epithelium 2 midbrain 2 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 143 100.00 Enkephalin 31 100.00 agonist 28 100.00 narcan 27 100.00 antinociception 26 100.00 Analgesic 24 100.00 MU agonist 12 100.00 Nicotine 11 100.00 mu opioid receptor 5 100.00 midbrain 5 100.00

Disease Link Frequency Relevance Heat Stress 9 100.00 Shock 8 100.00 INFLAMMATION 6 99.82 Rheumatoid Arthritis 6 99.74 Infarction 2 99.60 Ganglion Cysts 7 99.48 Drug Induced Neurotoxicity 2 99.44 Pain 34 99.40 Targeted Disruption 2 99.28 Dyskinesias 5 98.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Prenatal exposure to morphine differentially alters gonadal hormone regulation of delta-opioid receptor binding in male and female rats.

Regulation (regulation) of delta-opioid Binding (binding) of in gonadal associated with opioid receptor and morphine

1) Confidence 0.61 Published 2000 Journal Brain Res. Bull. Section Title Doc Link 11179845 Disease Relevance 0.42 Pain Relevance 0.80

Polyarthritis induced by inoculation with complete Freund's adjuvant alters opioid peptides, but does not affect opioid receptor binding.

Neg (not) Regulation (affect) of opioid receptor Binding (binding) of associated with opioid receptor, opioid and arthritis

2) Confidence 0.58 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15507218 Disease Relevance 0.17 Pain Relevance 0.70

[Effect of opioid receptor ligands on cell division processes in the corneal epithelium of the white rat].

Regulation ([Effect) of opioid receptor Binding (ligands) of in corneal epithelium associated with narcan and opioid receptor

3) Confidence 0.45 Published 1987 Journal Biull Eksp Biol Med Section Title Doc Link 3620689 Disease Relevance 0.08 Pain Relevance 0.28

We therefore examined the effects of both a chronic and an acute stressor-90-h water deprivation and a single 20-min foot shock on opioid receptor binding in 17 specific rat brain nuclei. [3H]DSTLE (Tyr-D-Ser-Gly-Phe-Leu-Thr) and [3H]DAGO(Tyr-D-Gly-Phe-NMe-Phe-Gly-ol) were used to label delta and mu receptors, respectively.

Spec (examined) Regulation (effects) of opioid receptor Spec (examined) Binding (binding) of in brain associated with shock and opioid receptor

4) Confidence 0.40 Published 1992 Journal Neuroscience Section Abstract Doc Link 1336824 Disease Relevance 0.39 Pain Relevance 0.50

We examined the effects of peripherally applied kappa- and delta-opioid receptor agonists and of their interactions with the NO-releasing drug, FK409, on the behavioral response to intraplantar injection of formalin in rats (the formalin test).

Spec (examined) Regulation (effects) of delta-opioid receptor Spec (examined) Binding (interactions) of associated with agonist and opioid receptor

5) Confidence 0.38 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9706936 Disease Relevance 0 Pain Relevance 0.78

The influence of replacing the phenolic hydroxyl by the methoxy group on opioid receptor binding, analgesic and antitussive action was investigated in the corresponding couples morphine-codeine, hydromorphone-hydrocodone and O-desmethyltramadol (L 235)-tramadol.

Spec (investigated) Regulation (influence) of opioid receptor Binding (binding) of associated with tramadol, analgesic, opioid receptor, codeine and morphine

6) Confidence 0.27 Published 1988 Journal Arzneimittelforschung Section Abstract Doc Link 2849950 Disease Relevance 0.06 Pain Relevance 0.94

Prenatal and postnatal exposure to diazepam: effects on opioid receptor binding in rat brain cortex.

Regulation (effects) of opioid receptor Binding (binding) of in brain associated with opioid receptor

7) Confidence 0.27 Published 1983 Journal Eur. J. Pharmacol. Section Title Doc Link 6319157 Disease Relevance 0 Pain Relevance 0.48

Measurement of changes in opioid receptor binding in vivo during trigeminal neuralgic pain using [11C] diprenorphine and positron emission tomography.

Regulation (changes) of opioid receptor Binding (binding) of associated with pain, positron emission tomography and opioid receptor

8) Confidence 0.26 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Title Doc Link 10413036 Disease Relevance 0.55 Pain Relevance 0.75

Based on concepts that endogenous opioids participate in neural transmission of pain, the present study in central poststroke pain (CPSP) patients investigated changes in opioid receptor (OR) binding in neural structures centrally involved in the processing of pain.

Spec (investigated) Regulation (changes) of opioid receptor Binding (binding) of in neural associated with pain, endogenous opioid, opioid receptor and poststroke pain

9) Confidence 0.26 Published 2004 Journal Pain Section Abstract Doc Link 15030940 Disease Relevance 0.54 Pain Relevance 0.86

These results suggest that every oxygenated functional group in naltrexone (1) plays an important role in binding to the opioid receptor.

Regulation (role) of opioid receptor Binding (binding) of associated with opioid receptor

10) Confidence 0.26 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 14723960 Disease Relevance 0 Pain Relevance 0.45

Central pain after pontine infarction is associated with changes in opioid receptor binding: a PET study with 11C-diprenorphine.

Regulation (changes) of opioid receptor Binding (binding) of associated with pain, central pain, opioid receptor and infarction

11) Confidence 0.26 Published 1999 Journal AJNR Am J Neuroradiol Section Title Doc Link 10319982 Disease Relevance 0.45 Pain Relevance 0.77

[Comparative effect of opioid receptor ligands on cell division in the epithelium of the tongue in white rats].

Regulation (effect) of opioid receptor Binding (ligands) of in epithelium associated with narcan and opioid receptor

12) Confidence 0.25 Published 1987 Journal Biull Eksp Biol Med Section Title Doc Link 2959333 Disease Relevance 0.09 Pain Relevance 0.37

We have examined the possible involvement of beta-endorphin, an endogenous opioid, in the hypergravity-induced analgesic effects on rats and its counteraction by naloxone, an opioid receptor antagonist.

Spec (possible) Regulation (effects) of opioid receptor Binding (counteraction) of associated with antagonist, analgesic, narcan, endogenous opioid and opioid receptor

13) Confidence 0.25 Published 2001 Journal J Gravit Physiol Section Abstract Doc Link 12650193 Disease Relevance 0.38 Pain Relevance 0.60

Multiple sites of divalent cation modulation of delta opioid receptor binding.

Regulation (modulation) of delta opioid receptor Binding (binding) of associated with opioid receptor

14) Confidence 0.24 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2828955 Disease Relevance 0 Pain Relevance 0.22

Effects of stress on opioid receptor binding in the rat central nervous system.

Regulation (Effects) of opioid receptor Binding (binding) of in central nervous system associated with stress, analgesic, central nervous system and opioid receptor

15) Confidence 0.24 Published 1992 Journal Neuroscience Section Title Doc Link 1336824 Disease Relevance 0.42 Pain Relevance 0.70

Lesioning of the nucleus basalis of Meynert has differential effects on mu, delta and kappa opioid receptor binding in rat brain: a quantitative autoradiographic study.

Regulation (effects) of opioid receptor Binding (binding) of in brain associated with kappa opioid receptor and enkephalin

16) Confidence 0.21 Published 1992 Journal Brain Res. Section Title Doc Link 1327399 Disease Relevance 0 Pain Relevance 0.65

The preliminary data demonstrates that LPA at physiological concentrations (100-400 nM) was capable of modulating opioid receptor binding. 100 nM free lysophosphatidic acid concentration stimulates while 200 and 400 nM concentrations inhibit binding.

Regulation (modulating) of opioid receptor Binding (binding) of associated with opioid receptor

17) Confidence 0.20 Published 1998 Journal Neurobiology (Bp) Section Abstract Doc Link 10220777 Disease Relevance 0 Pain Relevance 0.31

Brain stimulation-induced feeding alters regional opioid receptor binding in the rat: an in vivo autoradiographic study.

Regulation (alters) of opioid receptor Binding (binding) of in Brain associated with opioid receptor

18) Confidence 0.18 Published 1990 Journal Brain Res. Section Title Doc Link 1963108 Disease Relevance 0 Pain Relevance 0.64

The role of microtubules in opioid receptor binding was studied by using microtubule assembly inhibitors.

Regulation (role) of opioid receptor Binding (binding) of associated with opioid receptor

19) Confidence 0.18 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3020468 Disease Relevance 0 Pain Relevance 0.33

In the present study, whole-cell patch-clamp recording was performed on acutely isolated rat dorsal root ganglion (DRG) neurons to evaluate the effects of the highly specific mu-opioid agonist ohmefentanyl and the delta-opioid agonist DPDPE on voltage-gated calcium channels and the possible interaction between CCK-8 receptor and mu- or delta-opioid receptor.

Spec (possible) Regulation (effects) of delta-opioid receptor Binding (interaction) of in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, mu agonist, calcium channel and opioid receptor

20) Confidence 0.18 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8531095 Disease Relevance 0.48 Pain Relevance 1.12

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