INT63820

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Context Info
Confidence 0.77
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 10.37
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp7) extracellular region (Mmp7) proteinaceous extracellular matrix (Mmp7)
Anatomy Link Frequency
plasma 1
uterus 1
epithelium 1
kidney 1
Mmp7 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 43 100.00 Very High Very High Very High
Chronic pancreatitis 7 98.96 Very High Very High Very High
Dismenorea 14 98.72 Very High Very High Very High
cINOD 17 98.20 Very High Very High Very High
Inflammation 45 93.32 High High
cytokine 9 87.48 High High
rheumatoid arthritis 2 36.32 Quite Low
Hippocampus 2 13.72 Low Low
Crohn's disease 9 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenoma 10 99.84 Very High Very High Very High
Pancreatic Cancer 4 99.84 Very High Very High Very High
Sprains And Strains 248 99.72 Very High Very High Very High
Metastasis 7 99.58 Very High Very High Very High
Liver Disease 6 99.36 Very High Very High Very High
Pancreatitis 7 98.96 Very High Very High Very High
Cancer 215 98.72 Very High Very High Very High
Dysmenorrhea 14 98.72 Very High Very High Very High
Cirrhosis 4 98.56 Very High Very High Very High
Adhesions 37 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice.
Gene_expression (expression) of matrilysin associated with adenoma
1) Confidence 0.77 Published 2008 Journal Carcinogenesis Section Title Doc Link 18499699 Disease Relevance 0.81 Pain Relevance 0.20
The results of this study demonstrated that sulindac was effective in increasing the expression of different collagens and decreasing the expression of Mmp7, effects that may contribute to altered tumor burden in cancer patients undergoing NSAIDs treatments.
Gene_expression (expression) of Mmp7 associated with cancer and cinod
2) Confidence 0.77 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.61 Pain Relevance 0.10
Studies with Apc(Min/+)/Mmp7(-/-) double-deficient mice demonstrated the reciprocal relationships of Mmp7 expression and the levels of these three collagens in vivo.
Gene_expression (expression) of Mmp7
3) Confidence 0.77 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.57 Pain Relevance 0.08
Reverse transcription-polymerase chain reaction validated gene expression of the Col6a2 subunit of collagen VI and of Mmp7.
Gene_expression (expression) of Mmp7
4) Confidence 0.77 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.81 Pain Relevance 0.14
The expression of Mmp7 varied between 5- and 15-fold between strains with the greatest difference observed in a comparison of 129X1/Sv and DBA/2 mice (Figure 3a).
Gene_expression (expression) of Mmp7 associated with sprains and strains
5) Confidence 0.74 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.73 Pain Relevance 0
Mmp7 was found in 'hot spot' areas within the tumors of Apc(Min/+) mice treated with the vehicle, but was greatly diminished in those mice treated with sulindac.
Gene_expression (found) of Mmp7 associated with cancer
6) Confidence 0.67 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.75 Pain Relevance 0.17
As shown in Figure 3b, transcript levels of Mmp7 and Sbp were four-fold higher and four-fold lower, respectively, in microdissected epithelium from 129X1/Sv relative to C57BL/6.
Gene_expression (levels) of Mmp7 in epithelium
7) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.82 Pain Relevance 0.03
The PCR product from pump-1 mRNA was clearly detected in both adenomyosis and normal uterus, as in postpartum uterus and kidney in which pump-1 is expressed.
Gene_expression (expressed) of pump-1 in uterus associated with dismenorea
8) Confidence 0.53 Published 1996 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 8752698 Disease Relevance 0.64 Pain Relevance 0.74
Of note, the large lysozyme and MMP7 positive cells in the villi did not reveal any granules (data not shown).
Gene_expression (lysozyme) of MMP7
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.08 Pain Relevance 0
The PCR product from pump-1 mRNA was clearly detected in both adenomyosis and normal uterus, as in postpartum uterus and kidney in which pump-1 is expressed.
Gene_expression (expressed) of pump-1 in kidney associated with dismenorea
10) Confidence 0.18 Published 1996 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 8752698 Disease Relevance 0.64 Pain Relevance 0.74
Synthesis of MMPs such as collagenase I (MMP-1), gelatinase B (MMP-9) and matrilysin (MMP-7) has been shown to be dependent on the synthesis of PG E2, suggesting that alterations in MMP expression may be instigated by alterations in PG synthesis [27,28,29,30].
Gene_expression (Synthesis) of MMP-7 associated with metalloproteinase
11) Confidence 0.11 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.25 Pain Relevance 0.05
For example, MMP-7 was shown to be one of the best discriminators between cirrhosis and precirrhotic stages in patients with chronic active hepatitis C [103].
Gene_expression (one) of MMP-7 associated with chronic hepatitis and cirrhosis
12) Confidence 0.10 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.17 Pain Relevance 0.51
Andrographolide may also inhibit angiogenesis for tumour metastasis via down-regulating matrix metalloproteinases-7 (MMP-7) expression, possibly by inactivating activator protein-1 (AP-1) through suppressing PI3K/Akt signalling pathway [58,59].
Gene_expression (expression) of matrix metalloproteinases-7 associated with metalloproteinase and metastasis
13) Confidence 0.02 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 1.23 Pain Relevance 0.13
Here, we test if matrix metalloproteinase 7 (MMP-7), a secreted protease frequently expressed in pancreatic carcinoma, can be measured in plasma, pancreatic, and duodenal juice, and if it can distinguish between periampullary carcinoma and chronic pancreatitis.
Gene_expression (expressed) of metalloproteinase 7 in plasma associated with pancreatic cancer, metalloproteinase, carcinoma and chronic pancreatitis
14) Confidence 0.01 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17507610 Disease Relevance 1.24 Pain Relevance 0.56

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