INT63822

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 14.15
Pain Relevance 5.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp23) endoplasmic reticulum (Mmp23)
Anatomy Link Frequency
Macrophages 2
uterus 2
brain 2
joint 1
leucocytes 1
Mmp23 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 333 100.00 Very High Very High Very High
Dismenorea 9 99.84 Very High Very High Very High
Inflammatory response 17 99.32 Very High Very High Very High
Inflammatory mediators 8 99.16 Very High Very High Very High
Glutamate 2 98.96 Very High Very High Very High
tolerance 17 97.40 Very High Very High Very High
Arthritis 166 97.32 Very High Very High Very High
chemokine 11 95.16 Very High Very High Very High
rheumatoid arthritis 173 94.96 High High
cytokine 108 94.56 High High
Disease Link Frequency Relevance Heat
Dysmenorrhea 9 99.84 Very High Very High Very High
Apoptosis 62 99.74 Very High Very High Very High
Adhesions 68 99.58 Very High Very High Very High
Arthritis 180 99.52 Very High Very High Very High
INFLAMMATION 192 99.32 Very High Very High Very High
Breast Cancer 9 99.12 Very High Very High Very High
Cancer 294 98.28 Very High Very High Very High
Obesity 127 97.68 Very High Very High Very High
Cardiomyopathy 6 97.54 Very High Very High Very High
Emphysema 10 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased invasion activity of endometrial stromal cells and elevated expression of matrix metalloproteinase messenger RNA in the uterine tissues of mice with experimentally induced adenomyosis.
Gene_expression (expression) of metalloproteinase in uterine associated with dismenorea and metalloproteinase
1) Confidence 0.43 Published 2001 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 11744912 Disease Relevance 0.10 Pain Relevance 0.28
[Expression of the small molecular weight matrix metalloproteinase in adenomyosis of the mouse uterus].
Gene_expression (Expression) of metalloproteinase in uterus associated with dismenorea and metalloproteinase
2) Confidence 0.25 Published 1996 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Title Doc Link 8752698 Disease Relevance 0.71 Pain Relevance 0.74
These crystals stimulate metalloproteinase production in vitro and also suppress metalloproteinase inhibitor production.
Gene_expression (production) of metalloproteinase associated with metalloproteinase
3) Confidence 0.23 Published 2003 Journal Curr Rheumatol Rep Section Abstract Doc Link 12744818 Disease Relevance 0.98 Pain Relevance 0.26
These crystals stimulate metalloproteinase production in vitro and also suppress metalloproteinase inhibitor production.
Gene_expression (production) of metalloproteinase associated with metalloproteinase
4) Confidence 0.23 Published 2003 Journal Curr Rheumatol Rep Section Abstract Doc Link 12744818 Disease Relevance 0.96 Pain Relevance 0.26
Macrophages and DCs are the main sources of MMP-12, a matrix metalloproteinase that has been described as the key proteolytic enzyme in the development of CS-induced emphysema in mice [31].
Gene_expression (sources) of metalloproteinase in Macrophages associated with emphysema and metalloproteinase
5) Confidence 0.05 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.47 Pain Relevance 0.22
METHODS: Primary mice oral fibroblasts were cultured, the effects of borneol on fibroblasts proliferation, cytotoxicity, collagen production, matrix metalloproteinases-2,9 (MMP-2,9) activities and tissue inhibitors of metalloproteinase 1 (TIMP-1) production were tested by methyl thiazolyl tetrazolium assay, lactic dehydrogenase activity assay, chloramine T method, gelatin zymography and enzyme-linked immunosorbent assay, respectively.
Gene_expression (production) of metalloproteinase in fibroblasts
6) Confidence 0.04 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.09 Pain Relevance 0
TUDCA treatment did not alter the levels of this metalloproteinase which was equivalent to control non-treated animals.
Gene_expression (levels) of metalloproteinase associated with metalloproteinase
7) Confidence 0.04 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.96 Pain Relevance 0.05
Insulin receptor–deficient macrophages exhibit increased susceptibility to lipid-induced apoptosis and reduced expression of matrix metalloproteinase 9
Gene_expression (expression) of metalloproteinase in macrophages associated with metalloproteinase and apoptosis
8) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.21 Pain Relevance 0.17
MMP-2 is a matrix metalloproteinase and strongly expressed in the stromal cells of mouse uterus during implantation period [27], [28].
Gene_expression (expressed) of metalloproteinase in uterus associated with metalloproteinase
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0.05 Pain Relevance 0.05
Overexpression of IDO or inhibition of endogenous IDO expression was accompanied by changes in metalloproteinase expression and also in the expression and activity of the cyclooxygenase enzymes.
Gene_expression (expression) of metalloproteinase associated with metalloproteinase
10) Confidence 0.02 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC31925 Disease Relevance 0.50 Pain Relevance 0.15
IDO axpression alters metalloproteinase expression
Gene_expression (expression) of metalloproteinase associated with metalloproteinase
11) Confidence 0.02 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.17 Pain Relevance 0.05
In a model of TNF-induced cardiomyopathy through cardiac-specific TNFalpha expression, p50 KO mice had improved diastolic and systolic function, suppressed matrix metalloproteinase activity and expression, and improved survival in male mice [53].
Gene_expression (expression) of metalloproteinase associated with cardiomyopathy and metalloproteinase
12) Confidence 0.02 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.53 Pain Relevance 0.20
Frantz et al. [51] found that postinfarct, p50 KO hearts had preserved ventricular dimensions, less matrix metalloproteinase expression, reduced collagen deposition, but higher TNFalpha expression.
Gene_expression (expression) of metalloproteinase in hearts associated with metalloproteinase
13) Confidence 0.02 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.48 Pain Relevance 0.20
The expression of metalloproteinase (MMP)-2, MMP-9, and urokinase plasminogen activator (uPA) was measured by gelatin zymography.
Gene_expression (expression) of metalloproteinase associated with metalloproteinase
14) Confidence 0.02 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2880989 Disease Relevance 1.36 Pain Relevance 0.25
For example, the cellular source of the TCAH-induced metalloproteinase activity is not yet known.
Gene_expression (source) of metalloproteinase associated with metalloproteinase
15) Confidence 0.02 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 0.47 Pain Relevance 0.21
overexpression or activation with ligands can reduce adhesion molecule and matrix metalloproteinase expression and activity in the vasculature, and prevent Rac1 and RhoA activation (Keen et al., 2004; Ramirez et al., 2008; Huang et al., 2009), thus protecting levels of tight junction proteins, and countering leukocyte–endothelial interactions and blood–brain barrier (BBB) compromise that occur in AD (Fiala et al., 2002; Zipser et al., 2007).
Gene_expression (expression) of metalloproteinase in brain associated with metalloproteinase, disease and adhesions
16) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.58 Pain Relevance 0.08
These studies indicate that IDO-mediated tryptophan depletion in vitro results in inhibition of matrix-degrading metalloproteinase enzyme production, suppression of inflammatory responses, and promotion of immune tolerance [3,4].
Gene_expression (production) of metalloproteinase associated with inflammatory response, tolerance and metalloproteinase
17) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.06 Pain Relevance 0.41
In this study, we analysed the movement of leucocytes after T. nattereri venom injection in the intraplantar region of Swiss mice, the production of pro-inflammatory mediators and the venom potential to elicit matrix metalloproteinase production and extracellular matrix degradation.
Gene_expression (production) of metalloproteinase in leucocytes associated with inflammatory mediators and metalloproteinase
18) Confidence 0.01 Published 2009 Journal Int J Exp Pathol Section Abstract Doc Link 19200249 Disease Relevance 0.88 Pain Relevance 0.54
For example, it has recently been reported that glutamate carboxypeptidase II (GCPII) (EC 3.4.17.21), a zinc metalloproteinase expressed in multiple tissues including the brain [143], was capable of cleaving A?
Gene_expression (expressed) of metalloproteinase in brain associated with glutamate and metalloproteinase
19) Confidence 0.01 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.36 Pain Relevance 0.22
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are a group of secreted enzymes; many of them have been found to be expressed in cartilage [1].
Gene_expression (expressed) of metalloproteinase in cartilage associated with metalloproteinase
20) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.09 Pain Relevance 0.09

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