INT63839

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 34.05
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nasal 3
brain 2
Nucleus 1
ciliary 1
goblet cell 1
CRS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 260 100.00 Very High Very High Very High
Hippocampus 20 99.68 Very High Very High Very High
Pain 34 99.44 Very High Very High Very High
Antihistamine 15 98.10 Very High Very High Very High
aspirin 126 98.08 Very High Very High Very High
fibrosis 39 97.12 Very High Very High Very High
Inflammatory marker 3 96.00 Very High Very High Very High
cINOD 43 90.96 High High
corticosteroid 15 90.20 High High
cytokine 33 86.24 High High
Disease Link Frequency Relevance Heat
Chronic Sinusitis 1182 100.00 Very High Very High Very High
INFLAMMATION 277 100.00 Very High Very High Very High
Syndrome 184 100.00 Very High Very High Very High
Recurrence 40 100.00 Very High Very High Very High
Congenital Rubella Syndrome 11 100.00 Very High Very High Very High
Gastroesophageal Reflux Disease 13 99.98 Very High Very High Very High
Asthma 165 99.76 Very High Very High Very High
Eosinophilia 93 99.72 Very High Very High Very High
Nasal Polyps 156 99.56 Very High Very High Very High
Stress 23 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRS is associated with lower airway disease such asthma, chronic obstructive pulmonary disease and bronchiectasis.
CRS Binding (associated) of associated with asthma, pulmonary disease, bronchiectasis, chronic sinusitis and disease
1) Confidence 0.41 Published 2010 Journal Expert Rev Respir Med Section Abstract Doc Link 20658908 Disease Relevance 2.07 Pain Relevance 0.29
The more common conditions that are associated with CRS are perennial allergic and nonallergic rhinitis, nasal polyps, and anatomical mechanical obstruction (septum/turbinate issues).
CRS Binding (associated) of in nasal associated with rhinitis, chronic sinusitis and hypersensitivity
2) Confidence 0.41 Published 2009 Journal Postgrad Med Section Abstract Doc Link 19940423 Disease Relevance 1.37 Pain Relevance 0.15
For example, inherent mucociliary defects such as those found in patients with cystic fibrosis or primary ciliary dyskinesia [5], [6], abnormal innate immunity [7], paranasal sinus anatomic variations [8], [9], environmental exposure [10], allergy, [11], [12] and microbial colonization [13], [14] have all been associated with CRS.
CRS Binding (associated) of in ciliary associated with kartagener syndrome, fibrosis, paranasal sinus disease, chronic sinusitis, hypersensitivity and cystic fibrosis
3) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017060 Disease Relevance 1.55 Pain Relevance 0.33
Another example: proton pump inhibitors are the modality of choice for the treatment of gastroesophageal reflux associated with CRS, but the efficacy on sinus symptoms is limited (Ulualp, Toohill, et al 1999; DiBiaise et al 2002).
CRS Binding (associated) of in sinus associated with chronic sinusitis and gastroesophageal reflux disease
4) Confidence 0.34 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936288 Disease Relevance 1.65 Pain Relevance 0.08
A relationship was established between the hormone binding by CRs of the hippocampus, rather than the rest of the brain, and type of animal behavior.
CRs Binding (binding) of in brain associated with hippocampus
5) Confidence 0.31 Published 1996 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 8755031 Disease Relevance 0.28 Pain Relevance 0.40
The action of the stress factor led to decreased binding of [3H]AS to CRs of both hippocampus and brain.
CRs Binding (binding) of in hippocampus associated with stress and hippocampus
6) Confidence 0.31 Published 1996 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 8755031 Disease Relevance 0.28 Pain Relevance 0.39
No asymmetry was shown in the distribution of CRs that bound [3H]AS in the rats of both groups.
CRs Binding (bound) of
7) Confidence 0.31 Published 1996 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 8755031 Disease Relevance 0.28 Pain Relevance 0.39
For example, oral antihistamines should be prescribed in patients with a proven allergy, but there is little evidence of their efficacy in CRS even with nasal polyps.
CRS Binding (efficacy) of in nasal associated with chronic sinusitis, antihistamine, hypersensitivity and nasal polyps
8) Confidence 0.26 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936288 Disease Relevance 1.70 Pain Relevance 0.09
Patients with CRS and patients suffering from CRSwNP both complain of nasal obstruction, discharge, facial pressure or pain, and smell disorders.
CRS Binding (Patients) of in nasal associated with pain, chronic sinusitis, nasal obstruction and loss of sense of smell
9) Confidence 0.26 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936288 Disease Relevance 1.41 Pain Relevance 0.20
Furthermore, CRS is characterized by basement membrane thickening, goblet cell hyperplasia, and prominent subepithelial fibrosis.
CRS Binding (characterized) of in goblet cell associated with fibrosis, chronic sinusitis and hyperplasia
10) Confidence 0.26 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936288 Disease Relevance 1.81 Pain Relevance 0.34
As with most surgical procedures, there is a paucity of randomized, controlled clinical trials examining the use of FESS in the management of CRS and CRSwNP (Chiu et al 2004).
CRS Binding (management) of associated with chronic sinusitis
11) Confidence 0.26 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936288 Disease Relevance 0.78 Pain Relevance 0.12
Besides vasoconstriction and sodium retention that lead to increased preload and afterload, one of the most deleterious actions of the RAAS in CRS is the activation of NADPH-oxidase by angiotensin II.
CRS Binding (actions) of associated with syndrome and increased venous pressure under development
12) Confidence 0.25 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3010630 Disease Relevance 0.85 Pain Relevance 0.11
While concentrations of LTC4/D4/E4, were significantly higher in CRS-NP compared to CRS and controls, no differences were observed in LTB4 levels between the groups.
CRS Binding (compared) of
13) Confidence 0.23 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.37 Pain Relevance 0.09
A substudy of the Follow-Up Serial Infusions of Nesiritide trial (FUSION I) demonstrated that in heart failure patients who were at high risk for CRS, infusion of nesiritide at two doses (0.005??
CRS Binding (risk) of in heart associated with syndrome and myocardial infarction
14) Confidence 0.22 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3010630 Disease Relevance 1.10 Pain Relevance 0
Although there is a growing recognition of the frequent presentation of the CRS, its underlying pathophysiology is not yet well understood, and no consensus regarding its appropriate management has been achieved.
CRS Binding (recognition) of associated with syndrome
15) Confidence 0.21 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3010630 Disease Relevance 2.28 Pain Relevance 0.04
Repeat CRS and IPCH in patients with diffuse peritoneal recurrence should be approached with caution and may be indicated only with effective second-line intraperitoneal chemotherapies.
CRS Binding (indicated) of associated with recurrence
16) Confidence 0.19 Published 2008 Journal Minerva Chir Section Abstract Doc Link 19078882 Disease Relevance 0.84 Pain Relevance 0.09
For admission to the Cortex+Nucleus group, subjects must have satisfied the following criteria: (1) Both cortical and nuclear muscimol abolish CRs for at least one 10-trial block, and to ?
CRs Binding (abolish) of in Nucleus
17) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0 Pain Relevance 0
The action of the stress factor led to decreased binding of [3H]AS to CRs of both hippocampus and brain.
CRs Binding (binding) of in brain associated with stress and hippocampus
18) Confidence 0.10 Published 1996 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 8755031 Disease Relevance 0.28 Pain Relevance 0.39
However, retrospective analysis was required to define the most critical factors associated with CRS so that prospective studies could focus on the most relevant issues.
CRS Binding (associated) of associated with chronic sinusitis
19) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1343550 Disease Relevance 0.97 Pain Relevance 0.22
The present study showed that being young, female and divorced or separated were all factors significantly associated with being a CSO.
CSO Binding (associated) of
20) Confidence 0.09 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2625355 Disease Relevance 0.06 Pain Relevance 0

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