INT63840

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 0.90
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 8
TM3 2
spinal cord 2
afferent neurons 2
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 168 100.00 Very High Very High Very High
GABA receptor 22 100.00 Very High Very High Very High
medulla 16 100.00 Very High Very High Very High
Spinal cord 10 100.00 Very High Very High Very High
anticonvulsant 2 99.28 Very High Very High Very High
noradrenaline 1 99.08 Very High Very High Very High
Glutamate 19 98.84 Very High Very High Very High
amygdala 54 98.82 Very High Very High Very High
adenocard 12 98.48 Very High Very High Very High
Central nervous system 17 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 7 92.88 High High
Fetal Death 1 87.08 High High
Affective Disorder 1 78.16 Quite High
Appetite Loss 2 75.84 Quite High
Traumatic Stress Disorders 1 73.60 Quite High
Obsessive-compulsive Disorder 1 70.00 Quite High
Anxiety Disorder 13 68.32 Quite High
Depression 32 68.00 Quite High
Voyeurism 1 53.84 Quite High
Exhibitionism 1 53.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in CeA neurons of HET mice, the previously characterized ethanol-induced increase of GABAA-IPSPs was abolished.
Positive_regulation (induced) of Positive_regulation (increase) of GABAA in neurons associated with amygdala
1) Confidence 0.49 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.15 Pain Relevance 0.37
In order to investigate whether GABAA receptor activation is not only able to increase PCNA content in TM3 cells, but indeed can stimulate TM3 cell proliferation, we performed proliferation assays (Figure 8).
Positive_regulation (increase) of Spec (whether) Positive_regulation (activation) of GABAA in TM3
2) Confidence 0.40 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0 Pain Relevance 0.63
Topiramate is an orally active anticonvulsant whose mechanisms of action include potentiation of GABA to activate GABAA receptors and antagonism of glutamate at specific receptors [17,18].
Positive_regulation (potentiation) of Positive_regulation (activate) of GABAA associated with glutamate, gaba and anticonvulsant
3) Confidence 0.33 Published 2006 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC1479813 Disease Relevance 0.59 Pain Relevance 0.32
Postsynaptic depolarization of a Purkinje neuron leads to an increase of the intracellular Ca2+ concentration, that together with calmodulin binds to and activates Ca2+/Calmodulin-dependent protein kinase II (CaMKII), thereby potentiating GABAA receptor function.
Positive_regulation (activates) of Positive_regulation (potentiating) of GABAA receptor in neuron
4) Confidence 0.32 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.03
9 gene increased expression levels of GABAA?
Positive_regulation (increased) of Positive_regulation (levels) of GABAA
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0 Pain Relevance 0.33
When recorded from Cav3.2(-/-) mice, T-type Ca(2+) current was totally abolished in this morphologically identified subset of neurons and GABA(A) receptors activation did not induce electrical activity nor intracellular Ca(2+) increase.
Neg (nor) Positive_regulation (induce) of Positive_regulation (activation) of GABA in neurons associated with gaba
6) Confidence 0.29 Published 2007 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 17716912 Disease Relevance 0 Pain Relevance 0.52
Activation of GABAA receptors in brainstem spinal cord and slice preparations from embryonic (on or after embryonic day 19) and neonatal rats slows respiration-related bursting when the preparations are bathed in artificial cerebrospinal fluid (aCSF) containing 3 mM K+, but increases burst frequency when the preparation are bathed in aCSF with elevated extracellular K+ (9 mM) [33].
Positive_regulation (increases) of Positive_regulation (Activation) of GABAA in spinal cord associated with medulla and spinal cord
7) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.07 Pain Relevance 0.45
Initially, only the property of direct activation of the GABA receptor by propofol was assumed to be dependent on the ?
Positive_regulation (dependent) of Positive_regulation (activation) of GABA associated with gaba receptor
8) Confidence 0.18 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866459 Disease Relevance 0 Pain Relevance 0.24
However, recent reports have indicated that the activation of GABAA receptors depolarizes primary afferent neurons and actually facilitates the release of GABAA, noradrenaline, adenosine, and luteinizing hormone (LH) in central and peripheral tissues.
Positive_regulation (facilitates) of Positive_regulation (activation) of GABAA in afferent neurons associated with adenocard and noradrenaline
9) Confidence 0.12 Published 1996 Journal Kurume Med J Section Abstract Doc Link 8755114 Disease Relevance 0 Pain Relevance 0.71
We treated differentiated neurons from precursor cells with 10 ┬ÁM kainic acid for 3 h and then stained with an antibody specific to GAD67, the key enzyme of GABA synthesis and responsible for GABA induction in mature granule neurons.
Positive_regulation (responsible) of Positive_regulation (induction) of GABA in neurons associated with gaba
10) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.09 Pain Relevance 0.52

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