INT63844

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.85
Pain Relevance 4.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkca) mitochondrion (Prkca) aging (Prkca)
endoplasmic reticulum (Prkca) plasma membrane (Prkca) nucleus (Prkca)
Anatomy Link Frequency
NG108-15 1
skeletal muscle 1
PVN 1
spinal cord dorsal horn 1
Prkca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endep 7 99.46 Very High Very High Very High
narcan 3 99.44 Very High Very High Very High
Dorsal horn 2 99.04 Very High Very High Very High
Spinal cord 2 98.80 Very High Very High Very High
Morphine 28 97.60 Very High Very High Very High
withdrawal 8 97.48 Very High Very High Very High
addiction 1 93.48 High High
medulla 3 92.60 High High
Kinase C 26 89.04 High High
tolerance 2 88.96 High High
Disease Link Frequency Relevance Heat
Glioma 2 98.86 Very High Very High Very High
Neuroblastoma 2 98.68 Very High Very High Very High
Toxocariasis 5 97.44 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 68.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coculturing myotubes within neuroblastoma X glioma hybrid clonal cell line (NG108-15) increased nPKC theta expression, but not cPKC alpha, suggesting that nPKC theta in skeletal muscle and myotubes is regulated by nerve contact or by a factor(s) provided by nerve.
Gene_expression (expression) of cPKC alpha in NG108-15 associated with neuroblastoma and glioma
1) Confidence 0.50 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8756430 Disease Relevance 0.20 Pain Relevance 0.39
Myoblast expression of nPKC theta was low, and the increase in nPKC theta expression that occurred during differentiation into myotubes resulted in levels of nPKC theta significantly below adult skeletal muscle. cPKC alpha expression in myoblastic increased during differentiation to levels that exceeded expression in adult skeletal muscle.
Gene_expression (expression) of cPKC alpha in skeletal muscle
2) Confidence 0.43 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8756430 Disease Relevance 0.18 Pain Relevance 0.46
The protein levels of PKCalpha and gamma were significantly down-regulated in the PVN and NTS/VLM from the morphine-withdrawn rats.
Gene_expression (levels) of PKCalpha in PVN associated with toxocariasis and morphine
3) Confidence 0.12 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16190878 Disease Relevance 0.48 Pain Relevance 1.50
Furthermore, long-term morphine infusion up-regulated PKA and PKC protein expression in the spinal cord dorsal horn, while amitriptyline inhibited the increase in expression of phospho-PKA, PKCalpha, PKCbetaII, and PKCgamma.
Gene_expression (expression) of PKCalpha in spinal cord dorsal horn associated with dorsal horn, endep, spinal cord and morphine
4) Confidence 0.04 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 2.23

General Comments

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