INT63845

Context Info Confidence 0.36 First Reported 1996 Last Reported 2007 Negated 1 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 0.23 Pain Relevance 1.23

protein targeting (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn) intracellular (Gphn) protein binding, bridging (Gphn) cytoplasm (Gphn)

Anatomy Link Frequency skeletal muscle 2 nucleus 2 spinal cord neurons 2 Gphn (Rattus norvegicus)

Pain Link Frequency Relevance Heat Kinase C 11 100.00 amygdala 62 99.36 Spinal cord 2 97.20 agonist 7 90.40 gABA 22 89.56 Central nervous system 2 89.52 Cannabinoid 5 88.68 tetrodotoxin 5 68.80 antagonist 2 57.56 hyperexcitability 1 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 122 98.32 Neuroblastoma 1 50.08 Stress 42 50.00 Glioma 1 49.44 Post-traumatic Stress Disorder 16 5.00 Shock 7 5.00 Cognitive Disorder 6 5.00 Injury 4 5.00 Phobia 3 5.00 Overactive Bladder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Modulation of glycine receptor subunits and gephyrin expression in the rat facial nucleus after axotomy.

Regulation (Modulation) of Gene_expression (expression) of gephyrin in nucleus

1) Confidence 0.36 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 15733085 Disease Relevance 0 Pain Relevance 0.07

The effects of chronic strychnine treatment on the expression and cellular distribution of gephyrin and glycine receptor were therefore tested using primary cultures of spinal cord neurons.

Regulation (effects) of Gene_expression (expression) of gephyrin in spinal cord neurons associated with spinal cord

2) Confidence 0.17 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.09

The proportion of gephyrin and glycine receptor-immunoreactive (IR) cells was unaffected by strychnine treatment.

Neg (unaffected) Regulation (unaffected) of Gene_expression (proportion) of gephyrin

3) Confidence 0.15 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.07

modulation of gephyrin and GABAA receptor expression

Regulation (modulation) of Gene_expression (expression) of gephyrin

4) Confidence 0.10 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838961 Disease Relevance 0.18 Pain Relevance 0.51

Neural influence on protein kinase C isoform expression in skeletal muscle.

Regulation (influence) of Gene_expression (expression) of isoform in skeletal muscle associated with kinase c

5) Confidence 0.01 Published 1996 Journal J. Neurosci. Section Title Doc Link 8756430 Disease Relevance 0.05 Pain Relevance 0.48

General Comments

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