INT6385

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Context Info
Confidence 0.61
First Reported 1981
Last Reported 2003
Negated 4
Speculated 8
Reported most in Abstract
Documents 48
Total Number 56
Disease Relevance 7.80
Pain Relevance 24.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
brain 5
nerve 4
hippocampus 3
blood 3
hypothalamus 2
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 136 100.00 Very High Very High Very High
agonist 111 100.00 Very High Very High Very High
antagonist 57 100.00 Very High Very High Very High
Analgesic 20 100.00 Very High Very High Very High
GABA receptor 1 100.00 Very High Very High Very High
gABA 8 99.96 Very High Very High Very High
anesthesia 3 99.92 Very High Very High Very High
allodynia 5 99.48 Very High Very High Very High
withdrawal 23 99.44 Very High Very High Very High
Spinal cord 7 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 26 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 3 99.76 Very High Very High Very High
Convulsion 10 99.56 Very High Very High Very High
Neuropathic Pain 6 99.48 Very High Very High Very High
Hypertension 4 98.96 Very High Very High Very High
Diuresis 3 98.96 Very High Very High Very High
Stress 4 98.92 Very High Very High Very High
Injury 5 98.52 Very High Very High Very High
Natriuresis 8 98.44 Very High Very High Very High
Opiate Addiction 6 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that DJ-7141 had no effect on alpha-2 adrenoceptors in gastric parasympathetic nerves.
Neg (no) Regulation (effect) of alpha-2 in parasympathetic nerves
1) Confidence 0.61 Published 1987 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2886689 Disease Relevance 0.29 Pain Relevance 0.52
Effects of various alpha 2 agonists, clonidine, guanfacine and B-HT 920, were studied on the diazepam withdrawal phenomena.
Regulation (Effects) of alpha 2 associated with agonist, withdrawal and clonidine
2) Confidence 0.45 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2878459 Disease Relevance 0.57 Pain Relevance 0.59
The effect of alpha 2 agonists and antagonists on the lower urinary tract of the rat.
Regulation (effect) of alpha 2 in lower urinary tract associated with anesthesia, antagonist and agonist
3) Confidence 0.45 Published 1993 Journal J. Urol. Section Title Doc Link 8093264 Disease Relevance 0.38 Pain Relevance 0.20
The effects of renal denervation and alpha 2-adrenoceptor blockade on diuresis and natriuresis in response to acute volume expansion (VE) were investigated in anaesthetized rats. 2.
Spec (investigated) Regulation (effects) of alpha 2 associated with natriuresis and diuresis
4) Confidence 0.45 Published 1999 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 10474774 Disease Relevance 0.42 Pain Relevance 0
Effects of two alpha 2 agonists, rilmenidine and clonidine, on the morphine withdrawal syndrome and their potential addictive properties in rats.
Regulation (Effects) of alpha 2 associated with agonist, withdrawal, morphine and clonidine
5) Confidence 0.45 Published 1988 Journal Am. J. Cardiol. Section Title Doc Link 2894155 Disease Relevance 0.26 Pain Relevance 1.26
Comparison of the effects of chronic desmethylimipramine administration on alpha 2- and beta-adrenoceptors in different regions of rat brain.
Regulation (effects) of alpha 2 in brain
6) Confidence 0.45 Published 1983 Journal Neuroscience Section Title Doc Link 6300728 Disease Relevance 0 Pain Relevance 0.17
The effects of ten once-daily injections of desmethylimipramine (10 mg/kg i.p.) on alpha 2- and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus and hypothalamus. [3H]clonidine and [3H]dihydroalprenolol were used as ligands for alpha 2- and beta-adrenoceptors, respectively.
Regulation (effects) of alpha 2 in hypothalamus associated with hippocampus and clonidine
7) Confidence 0.45 Published 1983 Journal Neuroscience Section Abstract Doc Link 6300728 Disease Relevance 0 Pain Relevance 0.17
It was observed that chronic treatment with chlorisondamine in doses that blocked ganglionic transmission produced a subsensitivity of the prejunctional alpha adrenoceptor system as evidenced by the fact that both the alpha-2 agonist, clonidine, and the alpha-2 antagonist, yohimbine, were less effective in decreasing or increasing nerve-stimulated induced contractions of the vas deferens, respectively.
Regulation (effective) of alpha-2 in nerve associated with antagonist, agonist and clonidine
8) Confidence 0.44 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6116794 Disease Relevance 0 Pain Relevance 0.40
It was observed that chronic treatment with chlorisondamine in doses that blocked ganglionic transmission produced a subsensitivity of the prejunctional alpha adrenoceptor system as evidenced by the fact that both the alpha-2 agonist, clonidine, and the alpha-2 antagonist, yohimbine, were less effective in decreasing or increasing nerve-stimulated induced contractions of the vas deferens, respectively.
Regulation (effective) of alpha-2 in nerve associated with antagonist, agonist and clonidine
9) Confidence 0.44 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6116794 Disease Relevance 0 Pain Relevance 0.41
The effects of four alpha 2 antagonists (yohimbine, rauwolscine, prazosin and WB 4101) and three alpha 2 agonists (clonidine, oxymetazoline and UK 14304) were examined.
Spec (examined) Regulation (effects) of alpha 2 associated with antagonist, agonist and clonidine
10) Confidence 0.44 Published 1993 Journal Brain Res. Section Abstract Doc Link 8097660 Disease Relevance 0 Pain Relevance 0.44
The effects of four alpha 2 antagonists (yohimbine, rauwolscine, prazosin and WB 4101) and three alpha 2 agonists (clonidine, oxymetazoline and UK 14304) were examined.
Spec (examined) Regulation (effects) of alpha 2 associated with antagonist, agonist and clonidine
11) Confidence 0.44 Published 1993 Journal Brain Res. Section Abstract Doc Link 8097660 Disease Relevance 0 Pain Relevance 0.48
Thus, these functional, anatomical and neurochemical correlates of the alpha 2 binding site distribution establish a neurological basis for the complex pharmacological effects of centrally acting alpha 2 agonists.
Regulation (effects) of alpha 2 associated with agonist
12) Confidence 0.44 Published 1984 Journal Brain Res. Section Abstract Doc Link 6324960 Disease Relevance 0.07 Pain Relevance 0.51
Idazoxan and mianserin did not affect the responsiveness of the postsynaptic 5-HT1A and alpha-2 adrenergic receptors as indicated by the unchanged suppressant effects of microiontophoretically applied 5-HT and NE.
Regulation (responsiveness) of alpha-2
13) Confidence 0.43 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7912278 Disease Relevance 0.08 Pain Relevance 0.32
The aim of the present study was to determine whether the alpha-2 adrenergic antagonists idazoxan (10 mg/kg/day x 21 days s.c.) and mianserin (5 mg/kg/day x 21 days s.c.), or electroconvulsive shocks (6 or 7 over a 2-week period) would also affect the alpha-2 adrenoceptors modulating 5-HT neurotransmission in the rat hippocampus.
Regulation (affect) of alpha-2 in hippocampus associated with antagonist, shock and hippocampus
14) Confidence 0.43 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7912278 Disease Relevance 0.10 Pain Relevance 0.53
The effects of ten, once-daily electroconvulsive shocks on alpha 2 and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus, hypothalamus and cerebellum. [3H]Clonidine and [3H]dihydroalprenolol were used as radioligands for alpha 2 and beta-adrenoceptors respectively.
Regulation (effects) of alpha 2 in hypothalamus associated with shock, hippocampus and clonidine
15) Confidence 0.42 Published 1982 Journal Neuroscience Section Abstract Doc Link 6289181 Disease Relevance 0.25 Pain Relevance 0.21
Comparison of the effects of repeated electroconvulsive shock on alpha 2- and beta-adrenoceptors in different regions of rat brain.
Regulation (effects) of alpha 2 in brain associated with shock
16) Confidence 0.42 Published 1982 Journal Neuroscience Section Title Doc Link 6289181 Disease Relevance 0.28 Pain Relevance 0.21
The nature of the effect of alpha-2 agonists on allodynia induced by L5 and L6 nerve ligation (Chung model) was thus examined.
Regulation (effect) of alpha-2 in nerve associated with allodynia, chung model and agonist
17) Confidence 0.41 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7815335 Disease Relevance 0.59 Pain Relevance 0.82
Moreover, it has been reported that the thermal hyperesthesia induced by a nerve constriction injury is sympathetically maintained and that spinally administered alpha 2 agonists can modulate the sympathetic outflow from the spinal cord.
Regulation (modulate) of alpha 2 in outflow associated with hyperesthesia, injury, hyperaesthesia, agonist and spinal cord
18) Confidence 0.41 Published 1996 Journal Anesthesiology Section Abstract Doc Link 8873554 Disease Relevance 0.60 Pain Relevance 1.04
The kd for the alpha 2 adrenoceptors was unaffected while the Bmax was significantly decreased only in the SC.
Neg (unaffected) Regulation (unaffected) of alpha 2 associated with spinal cord
19) Confidence 0.41 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780290 Disease Relevance 0 Pain Relevance 2.15
Evidence for the involvement of presynaptic alpha-2 adrenoceptors in the regulation of norepinephrine metabolism in the rat brain.
Regulation (involvement) of alpha-2 in brain
20) Confidence 0.39 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 3027307 Disease Relevance 0 Pain Relevance 0.21

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