INT63854

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Context Info
Confidence 0.56
First Reported 1996
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 27
Total Number 30
Disease Relevance 9.41
Pain Relevance 14.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
spinal cord 6
nerve 6
brain 4
spinal 2
hepatocytes 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 640 100.00 Very High Very High Very High
Morphine 25 100.00 Very High Very High Very High
intrathecal 14 100.00 Very High Very High Very High
Spinal cord 13 99.82 Very High Very High Very High
IPN 1 99.60 Very High Very High Very High
Thermal hyperalgesia 11 98.60 Very High Very High Very High
Pain 16 98.56 Very High Very High Very High
Periaqueductal grey 4 98.40 Very High Very High Very High
tolerance 439 97.92 Very High Very High Very High
Antihyperalgesic 4 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetic Cardiomyopathies 105 100.00 Very High Very High Very High
Nociception 7 100.00 Very High Very High Very High
Bordatella Infection 2 100.00 Very High Very High Very High
Inflammatory Pain 1 99.60 Very High Very High Very High
Diabetes Complications 2 99.16 Very High Very High Very High
Diabetes Mellitus 181 98.60 Very High Very High Very High
Hyperalgesia 13 98.60 Very High Very High Very High
Pain 14 98.56 Very High Very High Very High
Urological Neuroanatomy 6 98.40 Very High Very High Very High
Adult Respiratory Distress Syndrome 13 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to examine the effect of intrathecal (i.t.) injection of pertussis toxin (PTX) on the nociceptive threshold and protein kinase C (PKC) expression in the rat spinal cord.
Spec (examine) Regulation (effect) of Gene_expression (expression) of PKC in spinal cord associated with nociception, kinase c, bordatella infection, spinal cord and intrathecal
1) Confidence 0.56 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560106 Disease Relevance 0.46 Pain Relevance 0.34
We examined the role of nerve in regulating the expression of these PKC isoforms in rat skeletal muscle by denervating diaphragm muscle and measuring PKC protein expression at various postoperative times. nPKC theta protein levels decreased 65% after denervation, whereas cPKC alpha levels increased 80% compared with control hemidiaphragms.
Regulation (regulating) of Gene_expression (expression) of PKC in diaphragm associated with kinase c
2) Confidence 0.49 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8756430 Disease Relevance 0 Pain Relevance 0.47
PKC activity and protein expression did not change when assessed 1 h after bolus i.t. morphine in naive rats.
Neg (not) Regulation (change) of Gene_expression (expression) of PKC associated with kinase c and morphine
3) Confidence 0.45 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.84
Because changes in the expression of calcium-dependent protein kinases [protein kinase C (PKC)] are observed during pathological pain in the spinal cord, we examined the possible interactions between PKC and 3alpha5alphaNS at synaptic GABA(A)Rs.
Spec (examined) Regulation (changes) of Gene_expression (expression) of PKC in spinal cord associated with pain, gaba, kinase c and spinal cord
4) Confidence 0.45 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17767496 Disease Relevance 0.38 Pain Relevance 1.02
Sen et al, had further hypothesized that regulation of [Ca2+]i was a cellular mechanism through which PKC?
Regulation (through) of Gene_expression (mechanism) of PKC associated with kinase c
5) Confidence 0.44 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.41
The data support the overall hypothesis that down-regulating expression of PKC?
Regulation (support) of Gene_expression (expression) of PKC associated with kinase c
6) Confidence 0.44 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.39
The data support the overall hypothesis that down-regulating expression of PKC?
Regulation (regulating) of Gene_expression (expression) of PKC associated with kinase c
7) Confidence 0.44 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.38
Furthermore, if PKC?
Regulation (Furthermore) of Gene_expression (if) of PKC associated with kinase c
8) Confidence 0.44 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.36
To explore further how nerve regulates PKC expression, we characterized PKC isoform expression in rat myotubes deprived of neural input.
Regulation (regulates) of Gene_expression (expression) of PKC in nerve associated with kinase c
9) Confidence 0.36 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8756430 Disease Relevance 0.13 Pain Relevance 0.46
The PMF action was mediated by nuclear PKC activation but occurred independently from changes in PKC isozyme expression and enzyme translocation.
Regulation (changes) of Gene_expression (expression) of PKC
10) Confidence 0.32 Published 2000 Journal Cardiovasc. Res. Section Body Doc Link 10728432 Disease Relevance 0 Pain Relevance 0
Among the different PKC isoforms, PKC?
Regulation (different) of Gene_expression (isoforms) of PKC associated with kinase c
11) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.32 Pain Relevance 0.64
The present study attempted to characterize alterations in the immunoreactivity levels of PKC isozymes expressed in different brain areas in the rat following exposure to the nerve agent sarin (1x LD(50)).
Regulation (alterations) of Gene_expression (levels) of PKC in nerve associated with kinase c
12) Confidence 0.24 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15716382 Disease Relevance 0.34 Pain Relevance 0.42
The present study attempted to characterize alterations in the immunoreactivity levels of PKC isozymes expressed in different brain areas in the rat following exposure to the nerve agent sarin (1x LD(50)).
Regulation (alterations) of Gene_expression (expressed) of PKC in nerve associated with kinase c
13) Confidence 0.24 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15716382 Disease Relevance 0.34 Pain Relevance 0.45
both in vivo and in vitro, where as the expression of other two major isoforms of PKC, (PKC?
Regulation (as) of Gene_expression (expression) of PKC
14) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.42 Pain Relevance 0
both in liver tissues and hepatocytes with out changing the expression of other two major isoforms, PKC?
Regulation (changing) of Gene_expression (expression) of PKC in hepatocytes associated with kinase c
15) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.40 Pain Relevance 0.66
PKC family consists of at least 12 members and can be classified into three groups based on their biochemical properties and sequence homologies, e.g. conventional PKC isoforms (cPKC-?
Regulation (classified) of Gene_expression (isoforms) of PKC associated with kinase c
16) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.33 Pain Relevance 0.50
PKC family consists of at least 12 members and can be classified into three groups based on their biochemical properties and sequence homologies, e.g. conventional PKC isoforms (cPKC-?
Regulation (classified) of Gene_expression (isoforms) of PKC associated with kinase c
17) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.33 Pain Relevance 0.49
both in vivo and in vitro, where as the expression of other two major isoforms of PKC, (PKC?
Regulation (as) of Gene_expression (expression) of PKC
18) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.42 Pain Relevance 0
The effect of SJW on the PKC expression and activation was investigated in the periaqueductal grey (PAG) area by immunoblotting experiments.
Regulation (effect) of Gene_expression (expression) of PKC associated with periaqueductal grey
19) Confidence 0.22 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20045676 Disease Relevance 0.82 Pain Relevance 0.84
In agreement with the staurosporine data, down-regulation of PKC isoenzymes by a 24 h pre-treatment with phorbol 12,13-dibutyrate (1 ?
Regulation (regulation) of Gene_expression (isoenzymes) of PKC associated with kinase c
20) Confidence 0.18 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.37

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