INT63858

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Context Info
Confidence 0.05
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk) signal transducer activity (Oprm1)
Anatomy Link Frequency
neurons 1
Oprm1 (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 2 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Morphine 1 100.00 Very High Very High Very High
agonist 1 99.84 Very High Very High Very High
Locus ceruleus 8 97.68 Very High Very High Very High
opiate 2 86.80 High High
withdrawal 2 86.24 High High
Catecholamine 2 55.36 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 1 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Physiological studies have indicated that agonists at the mu-opioid receptor (mu OR), such as morphine or the endogenous peptide methionine5-enkephalin, can markedly decrease the spontaneous activity of noradrenergic neurons in the locus coeruleus (LC).
mu-opioid receptor Negative_regulation (decrease) of methionine5-enkephalin in neurons associated with locus ceruleus, agonist, enkephalin, opioid receptor and morphine
1) Confidence 0.05 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8756434 Disease Relevance 0.08 Pain Relevance 0.86

General Comments

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