INT63880

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 13.88
Pain Relevance 3.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FLNA) extracellular region (FLNA) plasma membrane (FLNA)
nucleus (FLNA) transcription factor binding (FLNA) cytoplasm (FLNA)
Anatomy Link Frequency
brachial artery 3
plasma 2
artery 1
neuron 1
lumen 1
FLNA (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 39 99.98 Very High Very High Very High
mu opioid receptor 24 99.84 Very High Very High Very High
agonist 4 99.28 Very High Very High Very High
Opioid 2 98.76 Very High Very High Very High
aspirin 22 98.38 Very High Very High Very High
withdrawal 8 97.44 Very High Very High Very High
Restless leg syndrome 9 97.20 Very High Very High Very High
rheumatoid arthritis 92 97.16 Very High Very High Very High
abdominal pain 2 93.04 High High
imagery 44 92.72 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 439 100.00 Very High Very High Very High
Hyperemia 18 100.00 Very High Very High Very High
Fibromuscular Dyplasia 5 100.00 Very High Very High Very High
Cv Unclassified Under Development 36 99.98 Very High Very High Very High
Urological Neuroanatomy 26 99.14 Very High Very High Very High
Stroke 171 98.96 Very High Very High Very High
Enteropathy 1 98.56 Very High Very High Very High
Atherosclerosis 71 97.80 Very High Very High Very High
Systemic Lupus Erythematosus 11 97.68 Very High Very High Very High
Rheumatoid Arthritis 104 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Benidipine significantly increased FMD (from 4.7+/-0.6 to 7.4+/-1.1%, P<0.05) and plasma cGMP levels.
Positive_regulation (increased) of FMD in plasma
1) Confidence 0.59 Published 2009 Journal Circ. J. Section Body Doc Link 19225210 Disease Relevance 0.07 Pain Relevance 0
A third function attributed to the MNS is that of empathizing with others, based on the finding that subjects that score higher on a questionnaire measuring their tendency to place themselves in the other person's shoes activate their MNS more strongly while hearing the actions of others (Gazzola et al. 2006).


Positive_regulation (activate) of MNS
2) Confidence 0.51 Published 2009 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2865077 Disease Relevance 0 Pain Relevance 0.12
However, it should be noted that one of the two studies [41] that found an improvement of FMD upon folic acid supplementation reported that participants ingested folic acid just before measurement of FMD.
Positive_regulation (improvement) of FMD
3) Confidence 0.44 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488898 Disease Relevance 0 Pain Relevance 0
Moreover, other studies have shown that methionine doses in the range of 10–50 mg/kg effectively increase plasma homocysteine concentrations and impair FMD [56,61].
Positive_regulation (increase) of FMD in plasma
4) Confidence 0.41 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.18 Pain Relevance 0
FMD was computed as the percent increase in arterial diameter: FMD% = {(maximum minus baseline)/baseline} × 100%.
Positive_regulation (increase) of FMD
5) Confidence 0.41 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.06 Pain Relevance 0.10
FMD was computed as the percent increase in arterial diameter: FMD% = {(maximum minus baseline)/baseline} × 100%.
Positive_regulation (increase) of FMD
6) Confidence 0.40 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488898 Disease Relevance 0.05 Pain Relevance 0.10
A significant decrease in FMD was observed in patients after exercise (at 30 minutes: 3.92 +/- 1.78% vs 7.03 +/- 1.99% at baseline, p < 0.001; at 2 hours: 6.36 +/- 2.12% vs 7.03 +/- 1.99% at baseline, p = 0.005), followed by a gradual return to its baseline value, whereas FMD in controls non-significantly increased after exercise.
Positive_regulation (increased) of FMD
7) Confidence 0.40 Published 2008 Journal Vasc Med Section Abstract Doc Link 18940901 Disease Relevance 0.74 Pain Relevance 0.16
We report a 39-yr-old male who developed ischemic bowel disease twice (once in the jejunal artery and once in the sigmoid artery) as a result of FMD.
Positive_regulation (result) of FMD in artery associated with fibromuscular dyplasia and enteropathy
8) Confidence 0.39 Published 1996 Journal Am. J. Gastroenterol. Section Abstract Doc Link 8759676 Disease Relevance 1.02 Pain Relevance 0.21
In recent years, evidence has accumulated for the existence of a mirror neuron system (MNS) for actions in humans (see figure 1a).
Positive_regulation (accumulated) of MNS in neuron
9) Confidence 0.37 Published 2009 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2865077 Disease Relevance 0.05 Pain Relevance 0.17
Endothelium-dependent FMD was described previously to be significantly impaired in SLE [34], in rheumatoid arthritis [35], and in antiphospholipid syndrome [29].
Positive_regulation (dependent) of FMD in Endothelium associated with anti-phospholipid antibody syndrome, rheumatoid arthritis, systemic lupus erythematosus and increased venous pressure under development
10) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.60 Pain Relevance 0.05
Ultrasound measurements of brachial artery FMD and carotid artery IMT
Positive_regulation (measurements) of FMD in brachial artery associated with increased venous pressure under development
11) Confidence 0.18 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2621141 Disease Relevance 0.72 Pain Relevance 0.08
Images of the right brachial artery were then acquired at rest and during reactive hyperemia for quantification of FMD.
Positive_regulation (acquired) of FMD in brachial artery associated with hyperemia
12) Confidence 0.17 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.37 Pain Relevance 0
Individuals with elevated MPO levels on the examination day had greater impairment of FMD in association with PM2.5 than did individuals with low MPO levels on that day.
Positive_regulation (impairment) of FMD associated with urological neuroanatomy
13) Confidence 0.17 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.86 Pain Relevance 0
The level of internalized mu-opioid receptors, after 30-min exposure to agonist, was greatly reduced, suggesting a role for filamin in mu opioid receptor trafficking.
Positive_regulation (role) of filamin associated with agonist and mu opioid receptor
14) Confidence 0.15 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573758 Disease Relevance 0.14 Pain Relevance 0.70
Moreover, mu opioid receptors function normally in the absence of filamin A, as evidenced by studies of opioid binding and DAMGO inhibition of forskolin-stimulated adenylyl cyclase.
Positive_regulation (absence) of filamin associated with mu opioid receptor and opioid
15) Confidence 0.15 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573758 Disease Relevance 0.17 Pain Relevance 0.58
= 0.05) to detect a reduction in mean CIMT of 0.07 mm and an absolute increase in FMD of 1.6%.


Positive_regulation (increase) of FMD
16) Confidence 0.09 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2559819 Disease Relevance 0 Pain Relevance 0
The pooled estimate, including our data, was an absolute increase in FMD of 1.4% (95%CI 0.7, 2.1%, n = 1280, p < 0.0001) in vitamin-treated subjects compared with placebo (Figure 5).
Positive_regulation (increase) of FMD
17) Confidence 0.09 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2559819 Disease Relevance 0.13 Pain Relevance 0
The MF decrease may be the effect of the centrally generated progressive alteration of the activation of individual MNs as the relaxation time increases; this may be explained by the withdrawal of the tonic fusimotor driven spindle-support via the fusimotor loop [23].
Positive_regulation (activation) of MNs associated with withdrawal
18) Confidence 0.07 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC443861 Disease Relevance 0.40 Pain Relevance 0.05
Maximal treadmill exercise induced an acute worsening of FMD in both groups at baseline (aspirin = -1.15%, nitroaspirin = -1.76%); after four weeks treatment, the impairment of FMD induced by exercise was still present in the aspirintreated group (-1.46%) while it was abolished in the NCX 4016-treated group (+0.79%, p = 0.038 vs. aspirin).
Positive_regulation (induced) of FMD associated with aspirin and increased venous pressure under development
19) Confidence 0.06 Published 2007 Journal Thromb. Haemost. Section Abstract Doc Link 17334512 Disease Relevance 0.93 Pain Relevance 0.88
In addition, the modest increase in FMD associated with short-term B-vitamin treatment does not appear to be translated into improved vascular structure or sustained in the longer term.


Positive_regulation (increase) of FMD
20) Confidence 0.06 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2559819 Disease Relevance 0.32 Pain Relevance 0

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