INT63891

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Context Info
Confidence 0.51
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.96
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Ucp1) mitochondrion (Ucp1) transmembrane transport (Ucp1)
Anatomy Link Frequency
brown fat 2
skeletal muscle 1
BAT 1
Ucp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 2 96.64 Very High Very High Very High
antagonist 2 76.52 Quite High
opioid receptor 2 76.08 Quite High
qutenza 4 75.00 Quite High
Neuropeptide 4 75.00 Quite High
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 17 100.00 Very High Very High Very High
Aids-related Complex 8 100.00 Very High Very High Very High
Body Weight 8 88.68 High High
Diabetes Mellitus 5 84.36 Quite High
Weight Gain 4 46.88 Quite Low
Disorder Of Lipid Metabolism 7 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Food deprivation and NLTX treatment significantly and independently increased ARC NPY mRNA and decreased UCP mRNA levels in brown fat, suggesting a complex interaction between hypothalamic NPY and endogenous opioids in the regulation of energy balance.
Negative_regulation (deprivation) of UCP mRNA in brown fat associated with aids-related complex and endogenous opioid
1) Confidence 0.51 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8760232 Disease Relevance 0.35 Pain Relevance 0.24
Food deprivation and NLTX treatment significantly and independently increased ARC NPY mRNA and decreased UCP mRNA levels in brown fat, suggesting a complex interaction between hypothalamic NPY and endogenous opioids in the regulation of energy balance.
Negative_regulation (decreased) of UCP mRNA in brown fat associated with aids-related complex and endogenous opioid
2) Confidence 0.37 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8760232 Disease Relevance 0.34 Pain Relevance 0.24
UCP-1, which is expressed exclusively in BAT, expression levels are reduced in several rodent models of obesity (12).
Negative_regulation (reduced) of UCP in BAT associated with obesity
3) Confidence 0.29 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.83 Pain Relevance 0
A single dose of capsiate temporarily raised both UCP1 mRNA in brown adipose tissue and UCP3 mRNA in skeletal muscle.
Negative_regulation (raised) of UCP1 in skeletal muscle associated with obesity
4) Confidence 0.26 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12959953 Disease Relevance 0.46 Pain Relevance 0.14

General Comments

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