INT639

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Context Info
Confidence 0.44
First Reported 1977
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 4.68
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LAMC2) extracellular region (LAMC2) cell adhesion (LAMC2)
Anatomy Link Frequency
outflow 3
blood 1
plasma 1
CSF 1
lymphocyte 1
LAMC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
halothane 6 100.00 Very High Very High Very High
Morphine 9 99.52 Very High Very High Very High
ischemia 10 98.36 Very High Very High Very High
headache 18 96.72 Very High Very High Very High
Opioid 2 96.28 Very High Very High Very High
cva 33 95.48 Very High Very High Very High
Multiple sclerosis 5 79.08 Quite High
anesthesia 9 75.00 Quite High
epidural 3 75.00 Quite High
Neuritis 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Injury 10 100.00 Very High Very High Very High
Stroke 2 99.48 Very High Very High Very High
Blindness 6 99.40 Very High Very High Very High
Heart Rate Under Development 1 99.12 Very High Very High Very High
Brain Hemorrhage 10 98.96 Very High Very High Very High
Nervous System Injury 6 98.12 Very High Very High Very High
Pressure Volume 2 Under Development 1 96.92 Very High Very High Very High
Headache Disorders 6 96.72 Very High Very High Very High
Adhesions 24 96.24 Very High Very High Very High
Cv General 3 Under Development 20 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of the plasma and CSF concentrations of morphine and sufentanil on the hemodynamic changes during surgery were evaluated.
Regulation (influence) of CSF in plasma associated with morphine
1) Confidence 0.44 Published 1989 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 2524949 Disease Relevance 0.27 Pain Relevance 0.96
Lumbar CSF pressure, cerebral perfusion pressure, and systolic blood pressure did not change in the propofol group.
Neg (not) Regulation (change) of CSF in blood
2) Confidence 0.44 Published 1999 Journal Anesthesiology Section Body Doc Link 10422937 Disease Relevance 0 Pain Relevance 0
The presence of gap junctions in cell cultured from AGs may provide a pathway for intercellular communication, allowing the regulation of CSF passage.
Regulation (regulation) of CSF
3) Confidence 0.31 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.07 Pain Relevance 0
The expression of these junctional proteins is an important first step in demonstrating that arachnoidal cells grown from human AG tissue in vitro can exhibit some of the barrier properties previously recognized in intact AG tissue and may allow these cells to regulate CSF outflow.


Regulation (regulate) of CSF in outflow
4) Confidence 0.27 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.08 Pain Relevance 0
No indication was found, that either a high CSF gamma-globulin value and/or in a high degree of barrier damage was a prerequisite for the occurrence of conspicuous bands in the CSF gamma-globulin region.
Regulation (value) of CSF in bands
5) Confidence 0.26 Published 1977 Journal Eur. Neurol. Section Abstract Doc Link 67038 Disease Relevance 0.44 Pain Relevance 0.26
Blood and CSF levels of HIV viral load, monocyte chemotactic protein-1, macrophage colony-stimulating factor (M-CSF), matrix metalloproteinase-2, and tumor necrosis factor-alpha were measured in addition to CD4 lymphocyte cell count.
Regulation (measured) of CSF in lymphocyte
6) Confidence 0.26 Published 2005 Journal Neurology Section Body Doc Link 15753420 Disease Relevance 0.17 Pain Relevance 0
The upper reference value for CSF NfH(SMI35) levels (0.73 ng/ml) was defined as the 95% cumulative frequency from 416 CSF samples.
Regulation (value) of CSF in upper
7) Confidence 0.26 Published 2003 Journal J. Immunol. Methods Section Abstract Doc Link 12957406 Disease Relevance 0.39 Pain Relevance 0.11
The effects of halothane, alpha-chloralose, and differing concentrations of arterial pCO2 on injury volume and CSF beta-endorphin levels were studied in a feline model of experimental focal cerebral ischemia.
Regulation (effects) of CSF associated with brain hemorrhage, ischemia, injury and halothane
8) Confidence 0.26 Published 1997 Journal Mol. Chem. Neuropathol. Section Abstract Doc Link 9271003 Disease Relevance 0.73 Pain Relevance 0.48
Effects of halothane, alpha-chloralose, and pCO2 on injury volume and CSF beta-endorphin levels in focal cerebral ischemia.
Regulation (Effects) of CSF associated with brain hemorrhage, ischemia, injury and halothane
9) Confidence 0.26 Published 1997 Journal Mol. Chem. Neuropathol. Section Title Doc Link 9271003 Disease Relevance 0.87 Pain Relevance 0.56
These proteins allow the arachnoid cells to form a barrier to CSF egress, regulating the return of CSF to the venous circulation.
Regulation (regulating) of CSF
10) Confidence 0.20 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.37 Pain Relevance 0.06
To study the role of the arachnoidal cells in CSF outflow and its pathologies, we have developed an in vitro model of the CSF outflow pathway across the arachnoid granulations.
Regulation (role) of CSF in outflow
11) Confidence 0.20 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 1.01 Pain Relevance 0.36
These junctional proteins in particular may be important in allowing these arachnoidal cells to regulate CSF outflow.



Regulation (regulate) of CSF in outflow
12) Confidence 0.12 Published 2005 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC1285366 Disease Relevance 0 Pain Relevance 0
To study the role of AGs in CSF egress, we have grown cells from human AG tissue in vitro and have characterized their expression of those cytoskeletal and junctional proteins that may function in the regulation of CSF outflow.


Regulation (regulation) of CSF in CSF
13) Confidence 0.12 Published 2005 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC1285366 Disease Relevance 0.27 Pain Relevance 0.13

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