INT63902

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.71
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Htr4) plasma membrane (Htr4) cytoplasm (Htr4)
signal transducer activity (Htr4)
Anatomy Link Frequency
5-HT neuron 1
interneurons 1
Htr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 71 99.44 Very High Very High Very High
agonist 136 98.20 Very High Very High Very High
calcitonin gene related peptide 16 97.76 Very High Very High Very High
sSRI 100 97.40 Very High Very High Very High
antagonist 40 94.88 High High
5HT 5 93.12 High High
Calcitonin gene-related peptide 9 92.16 High High
Pyramidal cell 34 91.76 High High
qutenza 4 88.08 High High
tetrodotoxin 5 86.16 High High
Disease Link Frequency Relevance Heat
Dyspepsia 22 82.16 Quite High
Ganglion Cysts 2 79.92 Quite High
Vibrio Infection 2 75.00 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

202 73.84 Quite High
Diarrhoea 58 72.40 Quite High
Stress 6 61.20 Quite High
Volume Depletion And Dehydration 1 56.00 Quite High
INFLAMMATION 13 17.76 Low Low
Gallbladder Disease 5 10.36 Low Low
Gastrointestinal Disease 5 6.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of 5HT3 and 5HT4 receptors enhances gastrointestinal transit.
Positive_regulation (Activation) of 5HT4
1) Confidence 0.67 Published 2010 Journal Gut Pathog Section Body Doc Link PMC2876056 Disease Relevance 0.25 Pain Relevance 0.30
Stimulation of 5HT4 receptors by serotonin augments the release of Ach and CGRP.
Positive_regulation (Stimulation) of 5HT4 associated with calcitonin gene related peptide and serotonin
2) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503665 Disease Relevance 0.08 Pain Relevance 0.70
Stimulation of 5HT4 receptors on submucosal IPANs by serotonin augments the release of Ach and CGRP.
Positive_regulation (Stimulation) of 5HT4 associated with calcitonin gene related peptide and serotonin
3) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503665 Disease Relevance 0.07 Pain Relevance 0.67
Mucosal release of 5-HT with activation of 5-HT4 receptors on sensory neurons that relay via enteric interneurons to cholinergic motor neurons regulates the peristaltic reflex [45-48].
Positive_regulation (activation) of 5-HT4 in interneurons
4) Confidence 0.45 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1434748 Disease Relevance 0.08 Pain Relevance 0.07
Indeed, if it had been the case in the present experimental conditions, citalopram should have competed with RS 67333 to stimulate hippocampal 5-HT4 receptors, and consequently to induce the phosphorylation of CREB.
Positive_regulation (stimulate) of 5-HT4
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.31
In this case, indeed, the concomitant stimulation of 5-HT4 receptors did not only counteract the suppressing action of the SSRI, but actually resulted in an increase of the average DRN 5-HT neuron firing frequency, which amplitude was comparable to that induced by each 5-HT4 agonist alone.
Positive_regulation (stimulation) of 5-HT4 in 5-HT neuron associated with agonist and ssri
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.25
These findings suggest that choleraic mucin secretion is mediated primarily through the activation of a 5-HT4-like receptor.
Positive_regulation (activation) of 5-HT4-like
7) Confidence 0.40 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8764208 Disease Relevance 0.15 Pain Relevance 0.55

General Comments

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