INT63905

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 12.67
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
Anatomy Link Frequency
cornea 1
heart 1
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 5 100.00 Very High Very High Very High
qutenza 130 92.80 High High
abdominal pain 10 90.88 High High
Inflammation 23 74.88 Quite High
agonist 33 67.28 Quite High
fibrosis 14 61.20 Quite High
imagery 16 39.48 Quite Low
Action potential 1 38.24 Quite Low
Inflammatory response 6 34.76 Quite Low
Bile 3 30.04 Quite Low
Disease Link Frequency Relevance Heat
Cancer 427 100.00 Very High Very High Very High
Retinoblastoma 109 100.00 Very High Very High Very High
Chondrosarcoma 39 99.52 Very High Very High Very High
Genetic Predisposition To Disease 3 99.40 Very High Very High Very High
Malignant Neoplastic Disease 44 98.32 Very High Very High Very High
Metastasis 51 97.36 Very High Very High Very High
Apoptosis 47 96.96 Very High Very High Very High
Sarcoma 19 96.60 Very High Very High Very High
Osteogenic Sarcomas 88 96.48 Very High Very High Very High
Breast Cancer 257 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structural alterations of the retinoblastoma gene (RB1) seem to be involved in the pathogenesis.


Regulation (alterations) of retinoblastoma associated with retinoblastoma
1) Confidence 0.62 Published 2008 Journal World J Surg Oncol Section Abstract Doc Link PMC2615012 Disease Relevance 1.36 Pain Relevance 0.09
Structural alterations of the retinoblastoma gene (RB1) seem to be involved in the pathogenesis.


Regulation (alterations) of RB1 associated with retinoblastoma
2) Confidence 0.62 Published 2008 Journal World J Surg Oncol Section Abstract Doc Link PMC2615012 Disease Relevance 1.36 Pain Relevance 0.09
Alterations in RB1 are thoroughly investigated in soft tissue tumors [3].
Spec (investigated) Regulation (Alterations) of RB1 associated with cancer
3) Confidence 0.27 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2615012 Disease Relevance 2.20 Pain Relevance 0
In LASIK-induced neurotrophic epitheliopathy RB staining typically affects the cornea (Wilson and Ambrosio 2001; Savini et al 2004).
Regulation (affects) of RB in cornea
4) Confidence 0.25 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698717 Disease Relevance 0.98 Pain Relevance 0
We used a fast inactivation-deficient mutant (QQQ) of the human heart Na+ channel alpha-subunit (hH1a) to assess the influence of the inactivation gate on tetrodotoxin (TTX) use-dependent block (UDB) and postrepolarization block (PRB).
Regulation (influence) of PRB in heart associated with tetrodotoxin
5) Confidence 0.22 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8764254 Disease Relevance 0 Pain Relevance 0.45
Among molecules regulating the p53 and RB tumor suppressor pathways, mutation of p53, overexpression of cyclin D1b, LMW cyclin E are apparently associated with poor clinical outcome of patients.
Regulation (regulating) of RB associated with cancer
6) Confidence 0.15 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.19 Pain Relevance 0.13
These novel molecular markers have been chosen from the viewpoint of involvement in the regulation of the p53 and RB tumor suppressor pathways, DNA damage response, and angiogenesis/metastasis, which play critical roles in human breast cancer development.
Regulation (regulation) of RB associated with cancer, breast cancer and metastasis
7) Confidence 0.15 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.02 Pain Relevance 0
Gene alterations in p53, Rb and FHIT are reported to be responsible for the "switch" to a high-grade anaplastic sarcoma (dedifferentiated components) from monoclonal origin of demonstrated dedifferentiated chondrosaroma [24].
Regulation (alterations) of Rb associated with sarcoma
8) Confidence 0.15 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1526734 Disease Relevance 1.61 Pain Relevance 0
Rb is a tumor suppressor responsible for regulating the G1/S cell cycle checkpoint [64].
Regulation (responsible) of Rb associated with cancer and retinoblastoma
9) Confidence 0.09 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.77 Pain Relevance 0
DR contributed to the writing of the case report as did his colleagues HJ, RB and RH, all of whom were involved in diagnosing and managing the patient.
Regulation (colleagues) of RB
10) Confidence 0.09 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936924 Disease Relevance 0.51 Pain Relevance 0.14
RB contributed the idea for this trial, participated in the design and drafted the manuscript, CW participated in the statistical analysis and helped drafting the manuscript, DH participated in the design of the study, UP and US both participated in the collection of patient data, WK helped in the design and coordination of the study, GA recorded patient data, GL revised the manuscript critically, RM assisted in the statistical analysis, CZ and GS were important in the design of the study, the coordination and helped to draft the manuscript.
Regulation (drafted) of RB
11) Confidence 0.07 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1431554 Disease Relevance 0.11 Pain Relevance 0
Previous studies have shown that a majority of human SCLCs have mutations in Rb and p53, as well as a dysregulation in the E2F-Rb pathway [3], [4], [5].
Regulation (dysregulation) of Rb
12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.39 Pain Relevance 0.31
Although dysregulation of tumor suppressor genes and oncogenes, such as Rb, p53, and the genes critical to cell cycle control, genetic stability, and apoptosis have been identified in OS, consensus genetic changes that lead to OS development are poorly understood.
Regulation (dysregulation) of Rb associated with cancer, osteogenic sarcomas and apoptosis
13) Confidence 0.03 Published 2010 Journal PPAR Research Section Abstract Doc Link PMC2825651 Disease Relevance 1.17 Pain Relevance 0.06
We found that the treatments decreased the phosphorylation status of Rb but did not affect total Rb (Fig. 3A).


Neg (not) Regulation (affect) of Rb
14) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0

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