INT63910

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 1997
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
forearm 2
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
algogenic 1 99.98 Very High Very High Very High
Somatic pain 1 96.56 Very High Very High Very High
tolerance 1 90.04 High High
Pain threshold 2 85.04 High High
Analgesic 3 75.00 Quite High
Pain 1 75.00 Quite High
Antinociceptive 1 34.56 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 3 99.24 Very High Very High Very High
Pain 4 96.24 Very High Very High Very High
Nociception 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That is, at equieffective doses, a 60-min prior i.p. injection of ET-1 blocked the behavioral response to a subsequent i.p. injection of ET-1 or PpQ, but not of ACh, whereas a 60-min prior injection of ACh or of PpQ had no effect on a subsequent i.p. injection of ACh, PpQ or ET-1.
Neg (no) Regulation (effect) of Positive_regulation (injection) of ET-1
1) Confidence 0.43 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764328 Disease Relevance 0.14 Pain Relevance 0.12
The possible algogenic effects of elevated serum endothelin levels in cardiac syndrome X were investigated in a case-control study that examined somatic pain perception in the forearm during submaximal effort tourniquet and cold immersion tests.
Spec (possible) Regulation (effects) of Spec (possible) Positive_regulation (elevated) of serum endothelin in forearm associated with pain, algogenic, syndrome and somatic pain
2) Confidence 0.33 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9294999 Disease Relevance 0.51 Pain Relevance 0.42

General Comments

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