INT63921

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Context Info
Confidence 0.52
First Reported 1996
Last Reported 2008
Negated 4
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.16
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Pcdhga10) plasma membrane (Pcdhga10)
Pcdhga10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
5HT 4 94.96 High High
Serotonin 6 94.76 High High
Dopamine 4 93.44 High High
fluoxetine 4 92.08 High High
Hippocampus 8 84.00 Quite High
Somatosensory cortex 8 82.96 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 20 98.92 Very High Very High Very High
Hypothermia 20 98.64 Very High Very High Very High
Urological Neuroanatomy 8 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In comparison with the hypothermia seen with AMPT or KET pretreatment, pretreatment with FLUOX had no effect on CORE TEMP.
Neg (no) Regulation (effect) of CORE TEMP associated with hypothermia
1) Confidence 0.52 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764359 Disease Relevance 0.75 Pain Relevance 0.22
Rats treated with AMPT had no change in CORE TEMP until the MDMA was injected, at which time an immediate hypothermia was seen that continued for 240 min., with a peak low of 34.3 degrees C.
Neg (no) Regulation (change) of CORE TEMP associated with hypothermia
2) Confidence 0.20 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764359 Disease Relevance 0.60 Pain Relevance 0.22
Rats pretreated with KET had no change in CORE TEMP until MDMA was injected, at which time an immediate hypothermia was seen that continued for 180 minutes, with a peak low of 34.7 degrees C.
Neg (no) Regulation (change) of CORE TEMP associated with hypothermia
3) Confidence 0.20 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764359 Disease Relevance 0.48 Pain Relevance 0.22
This study looked at the effect on CORE TEMP of three drugs that protect against MDMA neurotoxicity in the rat.
Regulation (effect) of CORE TEMP associated with drug induced neurotoxicity
4) Confidence 0.20 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764359 Disease Relevance 0.33 Pain Relevance 0.18
Visual stimulation with 82 lux increased extracellular 5-HT in the mPFC and OccC also in anesthetized animals, but had no effect in the TempC.
Neg (no) Regulation (effect) of TempC
5) Confidence 0.01 Published 2008 Journal Neuroscience Section Abstract Doc Link 18378406 Disease Relevance 0 Pain Relevance 0.26

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