INT63922

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 1996
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mapt) cytoskeleton (Mapt) nucleus (Mapt)
enzyme binding (Mapt) cytoplasm (Mapt)
Anatomy Link Frequency
adrenal glands 2
Mapt (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 1 98.82 Very High Very High Very High
narcan 2 97.68 Very High Very High Very High
Antinociceptive 3 96.98 Very High Very High Very High
qutenza 2 93.12 High High
antinociception 2 87.96 High High
Inflammation 1 80.20 Quite High
Analgesic 2 78.24 Quite High
antagonist 2 73.80 Quite High
Morphine 1 67.80 Quite High
Paracetamol 1 65.48 Quite High
Disease Link Frequency Relevance Heat
Nociception 3 91.36 High High
INFLAMMATION 1 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its antinociceptive effect was insensitive to naloxone, suggesting the lack of involvement of endogenous opioid, was not modulated by adrenal glands and does not involve interaction with the L-arginine-nitric oxide pathway, activation of alpha-1 adrenoceptors or tau-aminobutyric acidB receptors, but requires, at least in part, the serotoninergic pathway.
Positive_regulation (activation) of tau Neg (not) Binding (interaction) of in adrenal glands associated with endogenous opioid, narcan and antinociceptive
1) Confidence 0.49 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764364 Disease Relevance 0.25 Pain Relevance 1.01

General Comments

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