INT63928

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 1996
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 51
Total Number 54
Disease Relevance 11.81
Pain Relevance 17.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
neurons 5
synapses 3
cortex 2
P19 1
DA neuron 1
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 350 100.00 Very High Very High Very High
orphanin 6 100.00 Very High Very High Very High
Pain 43 99.72 Very High Very High Very High
addiction 121 99.60 Very High Very High Very High
Kinase C 81 99.58 Very High Very High Very High
Lasting pain 38 98.92 Very High Very High Very High
ketamine 21 98.86 Very High Very High Very High
Opioid 54 98.84 Very High Very High Very High
Hippocampus 255 98.76 Very High Very High Very High
Spinal cord 53 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 595 100.00 Very High Very High Very High
Repression 134 100.00 Very High Very High Very High
Pain 87 98.92 Very High Very High Very High
Cognitive Disorder 158 98.60 Very High Very High Very High
Anxiety Disorder 134 98.56 Very High Very High Very High
Embryonal Carcinoma 6 97.56 Very High Very High Very High
Schizophrenia 289 97.52 Very High Very High Very High
Drug Dependence 25 97.24 Very High Very High Very High
Disease 291 97.04 Very High Very High Very High
Injury 36 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The deficit of endogenous NT-3 induced a decrease in NR1 and NR2A subunits at postnatal day (P) 0 and P3 mice respectively, whereas an upregulation was observed in 12 week old NT-3 +/- mice.
Negative_regulation (decrease) of NR1
1) Confidence 0.56 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.07 Pain Relevance 0.25
However, it is still unclear whether ketamine's general anesthetic actions are mediated primarily via blockade of NMDAR.
Spec (whether) Negative_regulation (blockade) of NMDAR associated with ketamine
2) Confidence 0.51 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385364 Disease Relevance 0.06 Pain Relevance 0.30
This indicates a disease modulatory role for ketamine in CRPS-1 pain, possibly via desensitization of NMDAR in the spinal cord or restoration of inhibitory sensory control in the brain.


Spec (possibly) Negative_regulation (desensitization) of NMDAR in brain
3) Confidence 0.49 Published 2010 Journal Eur J Pain Section Body Doc Link 19540140 Disease Relevance 0.16 Pain Relevance 0
Consistent with the reduction in NR2A protein in the PSDs of Neto1-null mice, which had no change in total NR2A abundance in whole brain, we identified a decrease in NMDAR EPSCs at Schaffer collateral-CA1 synapses, which are normally dominated by NR2A-containing receptors [40].
Negative_regulation (decrease) of NMDAR in synapses
4) Confidence 0.44 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.08
In addition, we used mice with a disrupted NMDAR1 gene that lack functional NMDARs (NR1-/-) to assess the physiological role of NMDARs.
Negative_regulation (disrupted) of NMDAR1 gene
5) Confidence 0.43 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764653 Disease Relevance 0 Pain Relevance 0.15
Because homozygous fNR1 mice do not produce stable mRNA encoding the NR1 subunit following Cre-mediated recombination (Tsien et al., 1996b), we assayed directly for loss of NR1 messenger RNA by in situ hybridization (Figure 6).
Negative_regulation (loss) of NR1
6) Confidence 0.41 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.09 Pain Relevance 0
In the present study, NR1 protein was markedly reduced in the prefrontal cortex of HB-EGF KO mice.
Negative_regulation (reduced) of NR1 protein in cortex associated with targeted disruption
7) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.83 Pain Relevance 0.43
Active siRNAs resulted in a 60 to 75% knockdown of NR1 mRNA and protein in the area of the virus injection.
Negative_regulation (knockdown) of NR1
8) Confidence 0.40 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17551091 Disease Relevance 0.43 Pain Relevance 0.65
NR1 subunit mRNA and dendritic protein are reduced by 80% in the area of the virus injection, and NMDA currents, but not AMPA currents, are reduced 86-88% in lamina II neurons.
Negative_regulation (reduced) of NR1 in neurons
9) Confidence 0.37 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12832526 Disease Relevance 0.67 Pain Relevance 0.65
A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain.
Negative_regulation (deletion) of NR1 in spinal cord dorsal horn associated with pain, nmda receptor, injury, dorsal horn and spinal cord
10) Confidence 0.37 Published 2003 Journal J. Neurosci. Section Title Doc Link 12832526 Disease Relevance 0.69 Pain Relevance 0.99
Because of the nature of the genetic lesion, a DA neuron selective deletion of NMDAR1, our data strongly suggest NMDAR1 mediated signals in DA neuron be an essential element for developing nicotine induced associative learning.
Negative_regulation (deletion) of NMDAR1 in DA neuron associated with nicotine
11) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0 Pain Relevance 0.35
We demonstrate a novel functional role for PrPC as a modulator of synaptic NMDA currents and also attribute a neuroprotective function to this molecule by way of its ability to suppress NMDAR activity.


Negative_regulation (suppress) of NMDAR
12) Confidence 0.36 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.09 Pain Relevance 0.05
PrPC and NR2D subunits could be coimmunoprecipitated from hippocampal homogenate, indicating that NR2D-containing receptors form a protein complex with PrPC, but it is unclear exactly how PrPC functionally inhibits NMDAR activity.
Negative_regulation (inhibits) of NMDAR
13) Confidence 0.36 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.03
In the region of the cortical injection site, NR1 mRNA levels were markedly reduced, suggesting that the lentivector injection had indeed induced a local NR1 KO (n?
Negative_regulation (reduced) of NR1 mRNA associated with targeted disruption
14) Confidence 0.35 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.23 Pain Relevance 0
Local decrease in NR1 mRNA abundance in fNR1 mice after cortical lentivector injection
Negative_regulation (decrease) of NR1 mRNA
15) Confidence 0.34 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.06 Pain Relevance 0
The reduction in tbLTP and NMDAR EPSCs at Schaffer collateral-CA1 synapses suggested that there might be a decrease in the abundance or function of synaptic NMDARs.
Negative_regulation (reduction) of NMDAR in synapses
16) Confidence 0.32 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.08 Pain Relevance 0.05
Consequently, if the decrease in NMDAR EPSCs was due to the reduced level of NR2A-NMDARs, the relative contribution of NR2B-NMDARs to synaptic NMDAR currents would be predicted to be increased in Neto1-null mice.
Negative_regulation (decrease) of NMDAR
17) Confidence 0.32 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.16
The enhanced synaptic plasticity is NMDA receptor dependent thus presumably blocked in the mutant mice missing NMDAR1 in the dopaminergic neurons.
Negative_regulation (blocked) of NMDAR1 in dopaminergic neurons associated with nmda receptor
18) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0.09 Pain Relevance 0.86
M of the NR2B selective inhibitor Ifenprodil resulted in only a 19 ± 9% (n = 5) inhibition of NMDAR current amplitude.
Negative_regulation (inhibition) of NMDAR
19) Confidence 0.31 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.15 Pain Relevance 0.03
mV (to relieve the voltage-dependent Mg+2 block of the NMDAR).
Negative_regulation (block) of NMDAR
20) Confidence 0.30 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox