INT63932

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2011
Negated 10
Speculated 29
Reported most in Body
Documents 537
Total Number 567
Disease Relevance 259.67
Pain Relevance 296.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 51
dorsal horn 32
spinal 28
spinal cord 26
nerve 15
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 3883 100.00 Very High Very High Very High
Spinal cord 2920 100.00 Very High Very High Very High
amygdala 2801 100.00 Very High Very High Very High
Inflammation 2275 100.00 Very High Very High Very High
Dorsal horn 1409 100.00 Very High Very High Very High
Anterior cingulate cortex 1163 100.00 Very High Very High Very High
Lasting pain 990 100.00 Very High Very High Very High
ischemia 978 100.00 Very High Very High Very High
qutenza 769 100.00 Very High Very High Very High
Kinase C 447 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 4852 100.00 Very High Very High Very High
Cv General 4 Under Development 733 100.00 Very High Very High Very High
Neuropathic Pain 2641 99.98 Very High Very High Very High
Nervous System Injury 2319 99.98 Very High Very High Very High
Cv Unclassified Under Development 224 99.98 Very High Very High Very High
INFLAMMATION 2147 99.92 Very High Very High Very High
Stress 726 99.92 Very High Very High Very High
Amputation 599 99.92 Very High Very High Very High
Hyperalgesia 1513 99.90 Very High Very High Very High
Death 578 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal ERK activation contributes to the regulation of bladder function in spinal cord injured rats.
Positive_regulation (activation) of ERK in spinal cord associated with overactive bladder and spinal cord
1) Confidence 0.70 Published 2006 Journal Exp. Neurol. Section Title Doc Link 16513110 Disease Relevance 0.68 Pain Relevance 0.42
Recently, it was demonstrated that ERK activation is upregulated in the spinal cord of rats with chronic bladder inflammation and contributes to bladder overactivity.
Positive_regulation (activation) of ERK in bladder associated with inflammation and spinal cord
2) Confidence 0.70 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.77 Pain Relevance 0.48
Overall, our results demonstrate increased activation of the ERK pathway in the spinal cord from SCI rats, restricted to spinal segments that receive sensory input arising from the bladder.
Positive_regulation (activation) of ERK in bladder associated with frailty and spinal cord
3) Confidence 0.70 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.85 Pain Relevance 0.44
RESULTS: Procaine (10(-4) to 10(-3) M) inhibited carbachol-induced tyrosine phosphorylation and ERK activation in a concentration-dependent manner.
Positive_regulation (activation) of ERK
4) Confidence 0.69 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
Although tetracaine, lidocaine, and bupivacaine similarly suppressed carbachol-induced tyrosine phosphorylation and ERK activation, neither tetrodotoxin, veratridine, nor ouabain affected the carbachol-induced ERKs activation.
Positive_regulation (activation) of ERK
5) Confidence 0.69 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
METHODS: Protein tyrosine phosphorylation and ERK activation induced by carbachol, an agonist for muscarinic acetylcholine receptors, were examined in rat pheochromocytoma PC12 cells, a model for investigating signal transduction.
Positive_regulation (activation) of ERK
6) Confidence 0.69 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
Then, in the presence of local anesthetic, the carbachol-induced tyrosine phosphorylation and ERK activation were evaluated.
Positive_regulation (activation) of ERK
7) Confidence 0.69 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
The inhibition of carbachol-induced ERK activation by procaine was not modified by a phosphatase inhibitor, calyculin A.
Positive_regulation (activation) of ERK
8) Confidence 0.69 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
Both ERKs were also activated by 4beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C, and fluoroaluminate (AlF4-), respectively, but procaine did not affect ERK activation induced by these two substances.
Positive_regulation (activation) of ERK
9) Confidence 0.69 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
Specifically, the activation of ERK in the recovery phase of EAN paralysis seems to be related in the survival of Schwann cells.
Positive_regulation (activation) of ERK in Schwann cells associated with neuritis and paralysis
10) Confidence 0.69 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15531088 Disease Relevance 1.13 Pain Relevance 0.89
In this study we investigated the role of the activation of the extracellular signal-regulated kinases 1 and 2 (ERK) in chronic inflammatory articular nociception.
Spec (investigated) Positive_regulation (activation) of ERK in articular associated with nociception and inflammation
11) Confidence 0.68 Published 2005 Journal Pain Section Abstract Doc Link 15979799 Disease Relevance 0.40 Pain Relevance 0.19
The role of ERK activation in the neuronal excitability in the chronically compressed dorsal root ganglia.
Positive_regulation (activation) of ERK in neuronal associated with neuronal excitability and sciatica
12) Confidence 0.68 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17490811 Disease Relevance 0.42 Pain Relevance 0.46
ERK activation was rapid (within minutes) and transient.
Positive_regulation (activation) of ERK
13) Confidence 0.68 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15733095 Disease Relevance 0.33 Pain Relevance 0.38
Additionally, we investigated the nature of bladder primary afferents responsible for spinal ERK activation.
Positive_regulation (activation) of ERK in spinal
14) Confidence 0.68 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15733095 Disease Relevance 0.23 Pain Relevance 0.19
From the present review it becomes clear that the activation of the ERK signalling pathway might be a key mechanism in the development and maintenance of altered pain states.
Positive_regulation (activation) of ERK associated with pain
15) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.60 Pain Relevance 0.50
ERK activation was observed in the perycaria of small primary afferent neurons [29, 30, 83, 94] (Fig. 2) but it also occurred in the peripheral processes of these cells [4, 6, 29, 30].
Positive_regulation (activation) of ERK in afferent neurons
16) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.34 Pain Relevance 0.33
Although crucial for neuronal survival, one should take in consideration that extremely prolonged activation of the ERK pathway can be deleterious.
Positive_regulation (activation) of ERK in neuronal
17) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.44 Pain Relevance 0.29
ERK activation by chronic noxious stimulation is not particularly different from that seen after acute noxious stimulation.
Positive_regulation (activation) of ERK
18) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.18 Pain Relevance 0.45
In the vast majority of situation, ERK activation occurs in the same areas.
Positive_regulation (activation) of ERK
19) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.21 Pain Relevance 0.47
In what concerns spinal ERK phosphorylation after visceral inflammation, the scarce studies available show that noxious stimulation of the chronic inflamed colon and bladder induces prolonged and intense ERK activation in the lumbosacral spinal cord [24, 36] where most of the primary afferents innervating these organs terminate.
Positive_regulation (activation) of ERK in colon associated with inflammation and spinal cord
20) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.66 Pain Relevance 0.51

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