INT63933

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 53
Total Number 53
Disease Relevance 22.83
Pain Relevance 33.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
spinal 10
neurons 8
dorsal horn 6
spinal cord 4
dorsal root ganglia 4
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 217 100.00 Very High Very High Very High
Dorsal horn neuron 88 100.00 Very High Very High Very High
Anterior cingulate cortex 77 100.00 Very High Very High Very High
Morphine 58 100.00 Very High Very High Very High
qutenza 24 100.00 Very High Very High Very High
Ventral tegmentum 20 100.00 Very High Very High Very High
Eae 20 100.00 Very High Very High Very High
Dorsal horn 113 99.98 Very High Very High Very High
dorsal rhizotomy 9 99.98 Very High Very High Very High
withdrawal 81 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 193 100.00 Very High Very High Very High
Injury 158 100.00 Very High Very High Very High
Ganglion Cysts 35 99.84 Very High Very High Very High
Pain 480 99.56 Very High Very High Very High
Neuropathic Pain 281 99.56 Very High Very High Very High
Hyperplasia 11 99.18 Very High Very High Very High
Hypoxia 107 99.12 Very High Very High Very High
Stress 27 98.84 Very High Very High Very High
Hypertrophy 7 98.64 Very High Very High Very High
Arthritis 205 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although tetracaine, lidocaine, and bupivacaine similarly suppressed carbachol-induced tyrosine phosphorylation and ERK activation, neither tetrodotoxin, veratridine, nor ouabain affected the carbachol-induced ERKs activation.
Negative_regulation (suppressed) of Positive_regulation (activation) of ERK
1) Confidence 0.58 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
RESULTS: Procaine (10(-4) to 10(-3) M) inhibited carbachol-induced tyrosine phosphorylation and ERK activation in a concentration-dependent manner.
Negative_regulation (inhibited) of Positive_regulation (activation) of ERK
2) Confidence 0.58 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
The inhibition of carbachol-induced ERK activation by procaine was not modified by a phosphatase inhibitor, calyculin A.
Negative_regulation (inhibition) of Positive_regulation (activation) of ERK
3) Confidence 0.58 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
Indeed, we found that ablation of lamina I/III projection neurons substantially reduced the activation of ERK in RVM neurons 8 days post surgery.
Negative_regulation (reduced) of Positive_regulation (activation) of ERK in neurons associated with projection neuron and rostral ventromedial medulla
4) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.84 Pain Relevance 0.87
Also, intrathecal RTX decreases sensory input, as shown by reduced spinal ERK activation.
Negative_regulation (reduced) of Positive_regulation (activation) of ERK in spinal associated with intrathecal
5) Confidence 0.43 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18824169 Disease Relevance 0.80 Pain Relevance 0.63
Accordingly, inhibition of ERK activation almost completely inhibited the facilitation of heat-induced currents in DRG neurons [35].
Negative_regulation (inhibition) of Positive_regulation (activation) of ERK in neurons
6) Confidence 0.42 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.58 Pain Relevance 0.59
Spinal 5-HT3 receptors seem to be involved as intrathecal administration of a selective antagonist of this receptor attenuates ERK activation induced by formalin injection in the paw [103].
Negative_regulation (attenuates) of Positive_regulation (activation) of ERK in paw associated with antagonist and intrathecal
7) Confidence 0.42 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.21 Pain Relevance 0.53
Chronic infusions of BDNF into the VTA reduced total ERK immunoreactivity with no change in ERK activity, and also blocked the morphine-induced increase in ERK activity.
Negative_regulation (blocked) of Positive_regulation (increase) of ERK associated with ventral tegmentum and morphine
8) Confidence 0.42 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764658 Disease Relevance 0.06 Pain Relevance 0.97
In both cases, several changes occur in the nervous system, which depend on the activation of the ERK pathway at the different neuronal levels, including dorsal root ganglia (DRG), spinal cord and supraspinal centres.
Negative_regulation (centres) of Positive_regulation (activation) of ERK in dorsal root ganglia associated with spinal cord
9) Confidence 0.41 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.61 Pain Relevance 0.65
The most commonly used strategy to prevent ERK activation is by blocking the activation of ERK by its upstream kinase MEK (Fig. 4).
Negative_regulation (blocking) of Positive_regulation (activation) of ERK
10) Confidence 0.41 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.80 Pain Relevance 0.84
The chronic morphine-induced increases in ERK activity and TH expression in the VTA also were blocked by local infusion of NMDA glutamate receptor antagonists, suggesting a role for glutamate in mediating these drug effects.
Negative_regulation (blocked) of Positive_regulation (increases) of ERK associated with ventral tegmentum, glutamate, antagonist, glutamate receptor and morphine
11) Confidence 0.41 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764658 Disease Relevance 0.09 Pain Relevance 1.24
The pretreatment with nifedipine by intrathecal administration reduced the ERK activation in the spinal lamina I-II both in the low frequency (0.05 Hz) and high frequency (0.5 Hz and 10 Hz) stimulation (Fig. 3C).
Negative_regulation (reduced) of Positive_regulation (activation) of ERK in spinal associated with intrathecal
12) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC1941723 Disease Relevance 0.06 Pain Relevance 0.53
Pretreatment of intrathecal MK-801 injection did not inhibit the number of pERK-ir profiles after low frequency (0.05 Hz) stimulation (Fig. 3D), while it clearly inhibited the spinal ERK activation induced by high frequency (0.5–10 Hz) stimulation (Fig. 3A, B).
Negative_regulation (inhibited) of Positive_regulation (activation) of ERK in spinal associated with intrathecal
13) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC1941723 Disease Relevance 0 Pain Relevance 0.34
The activated Erk level in the ACC was reduced at 45 min and declined at 90 min after formalin injection.
Negative_regulation (declined) of Positive_regulation (activated) of Erk associated with anterior cingulate cortex
14) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.51 Pain Relevance 0.44
The activated Erk level in the ACC was reduced at 45 min and declined at 90 min after formalin injection.
Negative_regulation (reduced) of Positive_regulation (activated) of Erk associated with anterior cingulate cortex
15) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.51 Pain Relevance 0.44
These results suggest that suppression of calcineurin and activation of ERK1/2 are interacting mechanisms involved in cardioprotection by delta-opioid receptor activation.
Negative_regulation (suppression) of Positive_regulation (activation) of ERK associated with opioid receptor
16) Confidence 0.41 Published 2006 Journal Basic Res. Cardiol. Section Abstract Doc Link 16619106 Disease Relevance 0.23 Pain Relevance 0.37
In addition, a prostaglandin E1 analog, OP-1206 alpha-CD, administered orally, improved the walking dysfunction, and further, inhibited activation of ERK following running 7 days after surgery.
Negative_regulation (inhibited) of Positive_regulation (activation) of ERK
17) Confidence 0.41 Published 2004 Journal Pain Section Abstract Doc Link 15082127 Disease Relevance 0.96 Pain Relevance 0.78
Naltrexone pretreatment prevented both the morphine-induced pERK down-regulation and pAkt up-regulation.
Negative_regulation (prevented) of Positive_regulation (morphine-induced) of pERK associated with morphine
18) Confidence 0.40 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 1.19
We therefore hypothesized that the loss of mechanical hypersensitivity in neuropathic pain states following ablation of lamina I/III projection neurons would be accompanied by reduced ERK activation in the RVM.
Negative_regulation (reduced) of Positive_regulation (activation) of ERK in projection neurons associated with hypersensitivity, neuropathic pain, projection neuron and rostral ventromedial medulla
19) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.87 Pain Relevance 0.96
Moreover, inhibition of ERK phosphorylation in the dorsal horn by intrathecal administration of U0126, an inhibitor of ERK activation, produced a striking alleviation of existing, long-term tactile allodynia of diabetic rats.
Negative_regulation (inhibitor) of Positive_regulation (activation) of ERK in dorsal horn associated with brush evoked pain, diabetes mellitus, dorsal horn and intrathecal
20) Confidence 0.38 Published 2008 Journal Glia Section Abstract Doc Link 18186080 Disease Relevance 1.42 Pain Relevance 1.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox