INT63934

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Context Info
Confidence 0.82
First Reported 1996
Last Reported 2011
Negated 1
Speculated 9
Reported most in Abstract
Documents 377
Total Number 386
Disease Relevance 150.52
Pain Relevance 188.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 42
spinal 29
spinal cord 22
dorsal horn 20
amygdala 18
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 2628 100.00 Very High Very High Very High
nMDA receptor 763 100.00 Very High Very High Very High
Sciatic nerve 724 100.00 Very High Very High Very High
intrathecal 697 100.00 Very High Very High Very High
Dorsal horn 694 100.00 Very High Very High Very High
dorsal root ganglion 597 100.00 Very High Very High Very High
Dorsal horn neuron 393 100.00 Very High Very High Very High
Kinase C 356 100.00 Very High Very High Very High
spinal dorsal horn 307 100.00 Very High Very High Very High
amygdala 2524 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 725 100.00 Very High Very High Very High
Spinal Cord Injury 581 99.98 Very High Very High Very High
INFLAMMATION 1703 99.96 Very High Very High Very High
Nociception 1373 99.96 Very High Very High Very High
Arthritis 588 99.96 Very High Very High Very High
Cystitis 110 99.96 Very High Very High Very High
Brain Injury 16 99.92 Very High Very High Very High
Pain 2421 99.84 Very High Very High Very High
Hypersensitivity 254 99.74 Very High Very High Very High
Drug Dependence 16 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal administration of PD98059, a specific inhibitor of ERK phosphorylation, reduced the frequency and amplitude of bladder contractions in SCI animals but not in spinal intact ones.
Phosphorylation (phosphorylation) of ERK in spinal associated with frailty and intrathecal
1) Confidence 0.82 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.89 Pain Relevance 0.47
The increase in spinal ERK phosphorylation was specifically restricted to L6 spinal segment.
Phosphorylation (phosphorylation) of ERK in spinal
2) Confidence 0.82 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.92 Pain Relevance 0.49
The long anesthesia drastically reduced the density of phosphorylated ERK immunopositive cells to about 15% of the short anesthesia condition.
Phosphorylation (phosphorylated) of ERK associated with anesthesia
3) Confidence 0.82 Published 2008 Journal J. Neurosci. Methods Section Abstract Doc Link 18294698 Disease Relevance 0 Pain Relevance 0.81
We compared effects of short (2 and 5 min) and long (>10 min) anesthesia by pentobarbital on the immunoreactivity for phosphorylated ERK in the visual and entorhinal cortices of rat.
Phosphorylation (phosphorylated) of ERK associated with anesthesia
4) Confidence 0.82 Published 2008 Journal J. Neurosci. Methods Section Abstract Doc Link 18294698 Disease Relevance 0 Pain Relevance 0.79
During attempts to examine the phosphorylation status of extracellular signal-regulated kinase (ERK) in cerebral cortex immunohistochemically, we determined whether deep anesthesia for euthanasia disturbs the phosphorylation status of ERK, because the anesthesia might influence activity-dependent phosphorylation of ERK.
Spec (examine) Phosphorylation (phosphorylation) of ERK in cerebral cortex associated with anesthesia and cerebral cortex
5) Confidence 0.82 Published 2008 Journal J. Neurosci. Methods Section Abstract Doc Link 18294698 Disease Relevance 0 Pain Relevance 0.56
During attempts to examine the phosphorylation status of extracellular signal-regulated kinase (ERK) in cerebral cortex immunohistochemically, we determined whether deep anesthesia for euthanasia disturbs the phosphorylation status of ERK, because the anesthesia might influence activity-dependent phosphorylation of ERK.
Phosphorylation (phosphorylation) of ERK in cerebral cortex associated with anesthesia and cerebral cortex
6) Confidence 0.82 Published 2008 Journal J. Neurosci. Methods Section Abstract Doc Link 18294698 Disease Relevance 0 Pain Relevance 0.75
During attempts to examine the phosphorylation status of extracellular signal-regulated kinase (ERK) in cerebral cortex immunohistochemically, we determined whether deep anesthesia for euthanasia disturbs the phosphorylation status of ERK, because the anesthesia might influence activity-dependent phosphorylation of ERK.
Phosphorylation (phosphorylation) of ERK in cerebral cortex associated with anesthesia and cerebral cortex
7) Confidence 0.82 Published 2008 Journal J. Neurosci. Methods Section Abstract Doc Link 18294698 Disease Relevance 0 Pain Relevance 0.67
The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses.
Phosphorylation (phosphorylation) of ERK
8) Confidence 0.82 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.45 Pain Relevance 0.32
To investigate whether the phosphorylation of extracellular signal-regulated kinase (ERK) is involved in autoimmune injury of the peripheral nervous system (PNS), the expression of phosphorylated ERK (p-ERK) was analyzed in experimental autoimmune neuritis (EAN) in rats.
Spec (whether) Phosphorylation (phosphorylation) of ERK in peripheral nervous system associated with peripheral nervous system, experimental autoimmune neuritis, injury and neuritis
9) Confidence 0.81 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15531088 Disease Relevance 0.55 Pain Relevance 0.49
To investigate whether the phosphorylation of extracellular signal-regulated kinase (ERK) is involved in autoimmune injury of the peripheral nervous system (PNS), the expression of phosphorylated ERK (p-ERK) was analyzed in experimental autoimmune neuritis (EAN) in rats.
Phosphorylation (phosphorylated) of ERK in peripheral nervous system associated with peripheral nervous system, experimental autoimmune neuritis, injury and neuritis
10) Confidence 0.81 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15531088 Disease Relevance 0.64 Pain Relevance 0.53
Based on these results, we postulated that the phosphorylation of ERK has an important role in the differentiation and survival of cells, including inflammatory cells and Schwann cells, in the rat sciatic nerve in EAN.
Phosphorylation (phosphorylation) of ERK in Schwann cells associated with inflammation, sciatic nerve and neuritis
11) Confidence 0.81 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15531088 Disease Relevance 1.00 Pain Relevance 0.92
Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats.
Phosphorylation (phosphorylation) of ERK associated with nociception and nociceptor
12) Confidence 0.81 Published 2005 Journal Pain Section Title Doc Link 15979799 Disease Relevance 0.61 Pain Relevance 0.43
Taken together, these findings suggest that ERK phosphorylation in spinal cord neurones plays an important role in chronic inflammatory articular pain and that its inhibition may provide significant anti-nociception.
Phosphorylation (phosphorylation) of ERK in articular associated with nociception, pain, arthralgia, inflammation and spinal cord
13) Confidence 0.81 Published 2005 Journal Pain Section Abstract Doc Link 15979799 Disease Relevance 0.88 Pain Relevance 0.40
Intrathecal administration of PD 98059, an inhibitor of ERK phosphorylation, reduced nociceptive behaviour induced by the ankle bend test in monoarthritic rats.
Phosphorylation (phosphorylation) of ERK in ankle associated with nociception and intrathecal
14) Confidence 0.81 Published 2005 Journal Pain Section Abstract Doc Link 15979799 Disease Relevance 0.67 Pain Relevance 0.39
Movement of the inflamed joint increased ERK phosphorylation in neurones of the superficial and deep ipislateral dorsal horn laminae of L3-L5 spinal cord segments.
Phosphorylation (phosphorylation) of ERK in dorsal horn associated with dorsal horn and spinal cord
15) Confidence 0.81 Published 2005 Journal Pain Section Abstract Doc Link 15979799 Disease Relevance 0.49 Pain Relevance 0.25
In addition, bladder noxious input conveyed in vanilloid-resistant primary afferents is important to spinal ERK phosphorylation in both noninflamed and CYP-inflamed animals.
Phosphorylation (phosphorylation) of ERK in spinal
16) Confidence 0.80 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15733095 Disease Relevance 0.34 Pain Relevance 0.33
Finally, we used a specific inhibitor of ERK phosphorylation to study the influence of these kinases on the bladder reflex activity of normal and inflamed bladders.
Phosphorylation (phosphorylation) of ERK in bladders
17) Confidence 0.80 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15733095 Disease Relevance 0.23 Pain Relevance 0.24
In the DRG, in contrast with acute noxious stimulation or inflammation, ERK phosphorylation occurred in medium-to-large neurons [81, 82, 83], as well as in satellite cells [82, 83], reflecting the involvement of A-fibres and glial cells in neuropathic pain.


Phosphorylation (phosphorylation) of ERK in neurons associated with inflammation and neuropathic pain
18) Confidence 0.80 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.58 Pain Relevance 0.48
In turn, MEK phosphorylates ERK at two tyrosine and threonine residues.
Phosphorylation (phosphorylates) of ERK
19) Confidence 0.80 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0 Pain Relevance 0
The reasons why ERK phosphorylation is upregulated by acute and chronic noxious conditions are various but a common denominator can be found.
Phosphorylation (phosphorylation) of ERK
20) Confidence 0.80 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.46 Pain Relevance 0.42

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